BRENDA - Enzyme Database show
show all sequences of 2.7.1.145

Structure and function of cellular deoxyribonucleoside kinases

Eriksson, S.; Munch-Petersen, B.; Johansson, K.; Eklund, H.; Cell. Mol. Life Sci. 59, 1327-1346 (2002)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
Bombyx mori
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
Drosophila melanogaster
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used forDNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
Bombyx mori
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used for DNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
Drosophila melanogaster
Cloned(Commentary)
Commentary
Organism
DNA and amino acid sequence determination and analysis, gene is located on chromosome 3 at position 91D-91E, expression of wild-type and mutant enzymes in Escherichia coli TK-deficient strain KY895
Drosophila melanogaster
Engineering
Amino acid exchange
Commentary
Organism
N45D/N64D
site-directed mutagenesis, mutant shows increased drug sensitivity and decreased inhibition by dTTP compared to the wild-type enzyme
Drosophila melanogaster
Inhibitors
Inhibitors
Commentary
Organism
Structure
dTTP
competitive versus ATP, feedback inhibition
Bombyx mori
dTTP
competitive versus ATP, feedback inhibition
Drosophila melanogaster
additional information
no inhibition by dNTPs other than dTTP
Bombyx mori
additional information
no inhibition by dNTPs other than dTTP
Drosophila melanogaster
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
positive cooperativity with all 4 natural deoxyribonucleosides, no hyperbolic Michaelis-Menten substrate kinetics
Bombyx mori
additional information
-
additional information
straight forward hyperbolic kinetic reaction mechanism following a compulsory ordered steady-state reaction mechanism with formation of a ternary complex
Drosophila melanogaster
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
dependent on
Bombyx mori
Mg2+
dependent on
Drosophila melanogaster
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + 2'-deoxyadenosine
Drosophila melanogaster
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
ATP + 2'-deoxycytidine
Drosophila melanogaster
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
ATP + 2'-deoxyguanosine
Drosophila melanogaster
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
ATP + 2'-deoxythymidine
Drosophila melanogaster
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bombyx mori
-
-
-
Drosophila melanogaster
Q9XZT6
dNK is the only deoxyriconucleoside kinase in the fruitfly
-
Reaction
Reaction
Commentary
Organism
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate
positive cooperativity mechanism, substrate and nucleotide interactions and binding sites, overview
Bombyx mori
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate
straight forward hyperbolic kinetic reaction mechanism following a compulsory ordered steady-state reaction mechanism with formation of a ternary complex, substrate interactions
Drosophila melanogaster
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + 1-beta-D-arabinofuranosylcytosine
-
661453
Drosophila melanogaster
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
-
-
-
?
ATP + 1-beta-D-arabinofuranosylthymine
-
661453
Drosophila melanogaster
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
-
661453
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
-
661453
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
-
661453
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
-
661453
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2-chloro-2'-deoxyadenosine
-
661453
Drosophila melanogaster
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
-
661453
Drosophila melanogaster
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + E-5-(2-bromovinyl)-2'-deoxyuridine
-
661453
Drosophila melanogaster
ADP + E-5-(2-bromovinyl)-2'-deoxyuridine phosphate
-
-
-
?
additional information
broad substrate specificity
661453
Drosophila melanogaster
?
-
-
-
-
additional information
substrate specificity, no activity with purine ribonucleosides and dideoxynucleosides
661453
Bombyx mori
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
dimer
-
Bombyx mori
dimer
-
Drosophila melanogaster
More
ternary and quarternary structure analysis, overview
Bombyx mori
More
ternary and quarternary structure analysis, overview
Drosophila melanogaster
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Drosophila melanogaster
Application (protein specific)
Application
Commentary
Organism
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
Bombyx mori
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
Drosophila melanogaster
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used forDNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
Bombyx mori
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used for DNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
Drosophila melanogaster
Cloned(Commentary) (protein specific)
Commentary
Organism
DNA and amino acid sequence determination and analysis, gene is located on chromosome 3 at position 91D-91E, expression of wild-type and mutant enzymes in Escherichia coli TK-deficient strain KY895
Drosophila melanogaster
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Drosophila melanogaster
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
N45D/N64D
site-directed mutagenesis, mutant shows increased drug sensitivity and decreased inhibition by dTTP compared to the wild-type enzyme
Drosophila melanogaster
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
dTTP
competitive versus ATP, feedback inhibition
Bombyx mori
dTTP
competitive versus ATP, feedback inhibition
Drosophila melanogaster
additional information
no inhibition by dNTPs other than dTTP
Bombyx mori
additional information
no inhibition by dNTPs other than dTTP
Drosophila melanogaster
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
positive cooperativity with all 4 natural deoxyribonucleosides, no hyperbolic Michaelis-Menten substrate kinetics
Bombyx mori
additional information
-
additional information
straight forward hyperbolic kinetic reaction mechanism following a compulsory ordered steady-state reaction mechanism with formation of a ternary complex
Drosophila melanogaster
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
dependent on
Bombyx mori
Mg2+
dependent on
Drosophila melanogaster
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + 2'-deoxyadenosine
Drosophila melanogaster
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
ATP + 2'-deoxycytidine
Drosophila melanogaster
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
ATP + 2'-deoxyguanosine
Drosophila melanogaster
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
ATP + 2'-deoxythymidine
Drosophila melanogaster
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + 1-beta-D-arabinofuranosylcytosine
-
661453
Drosophila melanogaster
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
-
-
-
?
ATP + 1-beta-D-arabinofuranosylthymine
-
661453
Drosophila melanogaster
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyadenosine
-
661453
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
-
661453
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyguanosine
-
661453
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
-
661453
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2-chloro-2'-deoxyadenosine
-
661453
Drosophila melanogaster
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
-
661453
Drosophila melanogaster
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + E-5-(2-bromovinyl)-2'-deoxyuridine
-
661453
Drosophila melanogaster
ADP + E-5-(2-bromovinyl)-2'-deoxyuridine phosphate
-
-
-
?
additional information
broad substrate specificity
661453
Drosophila melanogaster
?
-
-
-
-
additional information
substrate specificity, no activity with purine ribonucleosides and dideoxynucleosides
661453
Bombyx mori
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
-
Bombyx mori
dimer
-
Drosophila melanogaster
More
ternary and quarternary structure analysis, overview
Bombyx mori
More
ternary and quarternary structure analysis, overview
Drosophila melanogaster
Other publictions for EC 2.7.1.145
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738739
Kamiya
In vivo selection of active de ...
Drosophila melanogaster
J. Biotechnol.
228
52-57
2016
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1
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1
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738781
Slot Christiansen
Non-viral deoxyribonucleoside ...
Anopheles gambiae, Bombyx mori, Drosophila melanogaster
J. Genet. Genomics
42
235-248
2015
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2
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1
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3
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18
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3
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33
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18
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33
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7
7
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739211
Jiang
Tanshinone IIA enhances bystan ...
Drosophila melanogaster
Oncol. Rep.
34
1487-1493
2015
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1
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4
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1
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737404
Serra
-
Immobilized Drosophila melanog ...
Drosophila melanogaster
Adv. Synth. Catal.
356
563-570
2014
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1
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1
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1
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14
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1
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14
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1
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1
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703396
Betham
Use of Drosophila deoxynucleos ...
Drosophila melanogaster
DNA Repair
9
153-160
2010
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1
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4
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1
1
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721775
Ito
Cytotoxic effect of Drosophila ...
Drosophila melanogaster
Biol. Pharm. Bull.
33
1223-1227
2010
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1
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5
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702047
Knecht
Drosophila melanogaster deoxyr ...
Drosophila melanogaster
Biochem. Biophys. Res. Commun.
382
430-433
2009
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1
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1
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1
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1
1
692289
Mikkelsen
Structural studies of nucleosi ...
Drosophila melanogaster
FEBS J.
275
2151-2160
2008
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694476
Clausen
A multisubstrate deoxyribonucl ...
Arabidopsis thaliana
Nucleic Acids Symp. Ser.
52
489-490
2008
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1
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7
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673584
Egeblad-Welin
Functional studies of active-s ...
Drosophila melanogaster
FEBS J.
274
1542-1551
2007
-
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1
7
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18
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5
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18
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673848
Knecht
Drosophila deoxyribonucleoside ...
Drosophila melanogaster
Gene Ther.
14
1278-1286
2007
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1
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675450
Gerth
Non-homologous recombination o ...
Drosophila melanogaster
J. Mol. Biol.
370
742-751
2007
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6
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6
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1
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676100
Solaroli
Mitochondrial expression of th ...
Drosophila melanogaster
Mol. Pharmacol.
72
1593-1598
2007
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1
1
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1
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2
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2
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672880
Jordheim
Gemcitabine resistance due to ...
Drosophila melanogaster
Cancer Chemother. Pharmacol.
58
547-554
2006
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1
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4
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672971
Legent
In vivo analysis of Drosophila ...
Drosophila melanogaster
Cell Cycle
5
740-749
2006
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1
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Animal deoxyribonucleoside kin ...
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Investigation of the substrate ...
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Knecht
Mosquito has a single multisub ...
Anopheles gambiae
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662985
Krawiec
Ability of adenosine-2'(3')-de ...
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Johansson
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Balzarini
The multifunctional deoxynucle ...
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Johansson
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Munch-Petersen
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Munch-Petersen
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