medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
Bombyx mori
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
Drosophila melanogaster
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used forDNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
Bombyx mori
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used for DNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
Drosophila melanogaster
ATP + 1-beta-D-arabinofuranosylcytosine
661453
Drosophila melanogaster
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
?
ATP + 1-beta-D-arabinofuranosylthymine
661453
Drosophila melanogaster
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
?
ATP + 2'-deoxyadenosine
661453
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
?
ATP + 2'-deoxycytidine
661453
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
?
ATP + 2'-deoxyguanosine
661453
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
?
ATP + 2'-deoxythymidine
661453
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
?
ATP + 2-chloro-2'-deoxyadenosine
661453
Drosophila melanogaster
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
?
ATP + 5-fluoro-2'-deoxyuridine
661453
Drosophila melanogaster
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
?
ATP + E-5-(2-bromovinyl)-2'-deoxyuridine
661453
Drosophila melanogaster
ADP + E-5-(2-bromovinyl)-2'-deoxyuridine phosphate
?
additional information
broad substrate specificity
661453
Drosophila melanogaster
?
additional information
substrate specificity, no activity with purine ribonucleosides and dideoxynucleosides
661453
Bombyx mori
?
dNK
Drosophila melanogaster
More
the enzyme belongs to the thymidine kinase 2-like, i.e. TK2-like, family of enzymes
Bombyx mori
More
the enzyme belongs to the thymidine kinase 2-like, i.e. TK2-like, family of enzymes
Drosophila melanogaster
multisubstrate deoxyribonucleoside kinase
Bombyx mori
multisubstrate deoxyribonucleoside kinase
Drosophila melanogaster
nucleoside triphosphate: deoxyribonucleoside 5'-phosphotransferase
Drosophila melanogaster
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
Bombyx mori
medicine
enzyme with increased specificity towards certain analogues can be used as a suicide gene in combined gene/chemotherapy treatment of cancer
Drosophila melanogaster
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used forDNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
Bombyx mori
synthesis
enzyme can be utilized in industrial large-scale production of dNTPs and analogues, used for DNA synthetic reactions, giving a higher yield and less toxic byproducts compared to chemical processes
Drosophila melanogaster
ATP + 1-beta-D-arabinofuranosylcytosine
661453
Drosophila melanogaster
ADP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate
?
ATP + 1-beta-D-arabinofuranosylthymine
661453
Drosophila melanogaster
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
?
ATP + 2'-deoxyadenosine
661453
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
?
ATP + 2'-deoxycytidine
661453
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
?
ATP + 2'-deoxyguanosine
661453
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
?
ATP + 2'-deoxythymidine
661453
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
?
ATP + 2-chloro-2'-deoxyadenosine
661453
Drosophila melanogaster
ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate
?
ATP + 5-fluoro-2'-deoxyuridine
661453
Drosophila melanogaster
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
?
ATP + E-5-(2-bromovinyl)-2'-deoxyuridine
661453
Drosophila melanogaster
ADP + E-5-(2-bromovinyl)-2'-deoxyuridine phosphate
?
additional information
broad substrate specificity
661453
Drosophila melanogaster
?
additional information
substrate specificity, no activity with purine ribonucleosides and dideoxynucleosides
661453
Bombyx mori
?
738739
Kamiya
In vivo selection of active de ...
Drosophila melanogaster
J. Biotechnol.
228
52-57
2016
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1
-
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-
738781
Slot Christiansen
-
Non-viral deoxyribonucleoside ...
Anopheles gambiae, Bombyx mori, Drosophila melanogaster
J. Genet. Genomics
42
235-248
2015
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2
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3
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33
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7
7
-
-
-
739211
Jiang
Tanshinone IIA enhances bystan ...
Drosophila melanogaster
Oncol. Rep.
34
1487-1493
2015
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1
1
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4
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3
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1
1
-
-
-
737404
Serra
-
Immobilized Drosophila melanog ...
Drosophila melanogaster
Adv. Synth. Catal.
356
563-570
2014
-
1
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1
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1
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1
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14
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1
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1
-
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-
703396
Betham
Use of Drosophila deoxynucleos ...
Drosophila melanogaster
DNA Repair
9
153-160
2010
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1
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4
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1
1
-
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-
721775
Ito
Cytotoxic effect of Drosophila ...
Drosophila melanogaster
Biol. Pharm. Bull.
33
1223-1227
2010
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1
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5
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702047
Knecht
Drosophila melanogaster deoxyr ...
Drosophila melanogaster
Biochem. Biophys. Res. Commun.
382
430-433
2009
-
-
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1
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1
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-
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1
1
692289
Mikkelsen
Structural studies of nucleosi ...
Drosophila melanogaster
FEBS J.
275
2151-2160
2008
-
-
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694476
Clausen
A multisubstrate deoxyribonucl ...
Arabidopsis thaliana
Nucleic Acids Symp. Ser.
52
489-490
2008
-
-
1
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7
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7
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673584
Egeblad-Welin
Functional studies of active-s ...
Drosophila melanogaster
FEBS J.
274
1542-1551
2007
-
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1
7
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18
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673848
Knecht
Drosophila deoxyribonucleoside ...
Drosophila melanogaster
Gene Ther.
14
1278-1286
2007
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1
1
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2
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675450
Gerth
Non-homologous recombination o ...
Drosophila melanogaster
J. Mol. Biol.
370
742-751
2007
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6
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1
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676100
Solaroli
Mitochondrial expression of th ...
Drosophila melanogaster
Mol. Pharmacol.
72
1593-1598
2007
-
1
1
-
1
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-
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2
-
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2
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-
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-
-
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-
-
-
-
-
-
672880
Jordheim
Gemcitabine resistance due to ...
Drosophila melanogaster
Cancer Chemother. Pharmacol.
58
547-554
2006
-
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1
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4
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1
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-
-
-
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-
-
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-
-
-
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672971
Legent
In vivo analysis of Drosophila ...
Drosophila melanogaster
Cell Cycle
5
740-749
2006
-
-
-
-
-
-
-
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-
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3
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-
676247
Kamiya
Transient expression of Drosop ...
Drosophila melanogaster
Nucleosides Nucleotides Nucleic Acids
25
553-560
2006
-
1
1
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661702
Welin
Structural basis for the chang ...
Drosophila melanogaster
FEBS J.
272
3733-3742
2005
-
-
1
1
4
-
1
10
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1
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4
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2
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9
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4
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1
1
1
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4
10
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1
-
7
-
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9
-
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-
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-
-
-
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661731
Piskur
Animal deoxyribonucleoside kin ...
Drosophila melanogaster
FEBS Lett.
560
3-6
2004
-
-
-
-
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662990
Solaroli
Investigation of the substrate ...
Drosophila melanogaster
Nucleosides Nucleotides Nucleic Acids
23
1527-1529
2004
-
1
1
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3
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10
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10
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1
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1
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-
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-
660855
Krawiec
Inorganic tripolyphosphate (PP ...
Drosophila melanogaster
Biochem. Biophys. Res. Commun.
301
192-197
2003
-
-
-
-
-
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2
1
4
1
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1
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3
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661072
Mikkelsen
Structural basis for feedback ...
Drosophila melanogaster
Biochemistry
42
5706-5712
2003
-
-
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1
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1
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4
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3
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5
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661629
Solaroli
Active site mutants of Drosoph ...
Drosophila melanogaster
Eur. J. Biochem.
270
2879-2884
2003
-
-
1
-
9
-
-
9
-
-
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3
-
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1
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1
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9
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1
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1
1
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9
-
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9
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1
-
9
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1
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1
-
-
-
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-
-
-
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662967
Knecht
Mosquito has a single multisub ...
Anopheles gambiae
Nucleic Acids Res.
31
1665-1672
2003
-
2
1
-
-
-
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4
-
1
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4
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5
-
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1
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3
1
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14
-
2
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4
1
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1
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2
1
1
-
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4
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1
-
4
-
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1
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3
1
-
14
-
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-
4
1
-
-
-
-
-
-
-
-
-
662985
Krawiec
Ability of adenosine-2'(3')-de ...
Drosophila melanogaster
Nucleosides Nucleotides Nucleic Acids
22
1525-1529
2003
-
-
-
-
-
-
-
-
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5
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2
-
10
-
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-
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-
-
-
-
661453
Eriksson
Structure and function of cell ...
Bombyx mori, Drosophila melanogaster
Cell. Mol. Life Sci.
59
1327-1346
2002
-
4
1
-
1
-
4
2
-
2
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4
-
2
-
-
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2
-
-
-
-
11
4
7
-
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-
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1
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4
1
1
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1
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4
-
2
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2
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4
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11
4
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38
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1
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7
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2
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38
-
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1
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1
1
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8
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38
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1
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1
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1
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1
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7
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38
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1
2
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39
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9
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-
-
-
-
-
-
2
3
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-
-
-
3
2
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-
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-
6
3
12
2
2
12
2
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-
3
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1
2
-
39
5
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1
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2
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1
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3
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2
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1
1
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1
1
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-
2
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1
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3
-
1
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-
1
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-
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1
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2
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1
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1
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1
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1
1
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1
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1
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2
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4
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18
1
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4
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1
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1
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4
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1
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1
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4
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18
1
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636843
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3
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1
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3
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1
1
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3
5
1
1
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1
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3
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17
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12
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11
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1
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8
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17
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Johansson
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15
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1
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15
17
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4
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1
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4
1
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15
1
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1
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3
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4
3
4
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2
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1
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1
1
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15
1
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1
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21
1
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1
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4
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8
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4
8
5
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2
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1
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1
1
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21
1
1
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4
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