I102M/N117S/M118V/D208N
clones harbouring the mutant enzyme are more sensitive to 3'-azido-2',3'-dideoxythymidine and beta-D-arabinofuranosylcytosine
Drosophila melanogaster
I47T/N210D
clones harbouring the mutant enzyme are more sensitive to 3'-azido-2',3'-dideoxythymidine and beta-D-arabinofuranosylcytosine
Drosophila melanogaster
M1T/T85A/N121S
clones harbouring the mutant enzyme are more sensitive to 1-beta-D-arabinofuranosylcytosine and 2',3'-dideoxycytidine
Drosophila melanogaster
N210D/L239P
clones harbouring the mutant enzyme are more sensitive to 3'-azido-2',3'-dideoxythymidine and beta-D-arabinofuranosylcytosine
Drosophila melanogaster
N38D/N64D
clones harbouring the mutant enzyme are more sensitive specifically to 3'-azido-2',3'-dideoxythymidine
Drosophila melanogaster
N45D/N64D
clones harbouring the mutant enzyme are more sensitive to 3'-azido-2',3'-dideoxythymidine and other nucleoside analogs; mutant enzyme with the largest und universal increase in sensitivity of all mutants tested. 316fold increase to 3'-azido-2',3'-dideoxythymidine, more than 11fold to 2',3'-dideoxycytidine, and 3.2fold increase in sensitivity to beta-D-arabinofuranosylcytosine and 2',3'-dideoxyadenosine. Higher Km-values for native substrates than wild-type enzyme and Vmax-values are substantially lower, decrease in feedback inhibition by TTP, Km and Vmax values for 3'-azido-2',3'-dideoxythymidine and Km value for 2',3'-dideoxycytidine are nearly unchanged
Drosophila melanogaster
N59D/M118V/Y179H
clones harbouring the mutant enzyme are more sensitive to 3'-azido-2',3'-dideoxythymidine and beta-D-arabinofuranosylcytosine
Drosophila melanogaster
N64S/L68S/M69L
clones harbouring the mutant enzyme are more sensitive specifically to 3'-azido-2',3'-dideoxythymidine
Drosophila melanogaster
T12A/V84A/N213S
clones harbouring the mutant enzyme are more sensitive to 1-beta-D-arabinofuranosylcytosine
Drosophila melanogaster
T85A
clones harbouring the mutant enzyme are more sensitive to 1-beta-D-arabinofuranosylcytosine and 2',3'-dideoxycytidine
Drosophila melanogaster
V84A
clones harbouring the mutant enzyme are more sensitive to 1-beta-D-arabinofuranosylcytosine
Drosophila melanogaster
(E)-5-(2-bromovinyl)-2'-deoxyuridine + ATP
54% of the activity with thymidine
636844
Drosophila melanogaster
(E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate + ADP
?
1-beta-D-arabinofuranosylcytosine + ATP
58.2% of the activity with thymidine
636844
Drosophila melanogaster
1-beta-D-arabinofuranosylcytosine 5'-phosphate + ADP
?
1-beta-D-arabinofuranosylthymine + ATP
53.9% of the activity with thymidine
636844
Drosophila melanogaster
1-beta-D-arabinofuranosylthymine 5'-phosphate + ADP
?
2',3'-dideoxyadenosine + ATP
0.9% of the activity with thymidine
636844
Drosophila melanogaster
2',3'-dideoxyadenosine 5'-phosphate + ADP
?
2',3'-dideoxycytidine + ATP
636844
Drosophila melanogaster
2',3'-dideoxycytidine 5'-phosphate + ADP
?
2'-deoxyadenosine + ATP
636844
Drosophila melanogaster
2'-deoxyadenosine 5'-phosphate + ADP
?
2'-deoxycytidine + ATP
636844
Drosophila melanogaster
2'-deoxycytidine 5'-phosphate + ADP
?
2'-deoxyguanosine + ATP
636844
Drosophila melanogaster
2'-deoxyguanosine 5'-phosphate + ADP
?
2'-deoxyuridine + ATP
113% of the activity with thymidine
636844
Drosophila melanogaster
2'-deoxyuridine 5'-phosphate + ADP
?
2-chloro-2'-deoxyadenosine + ATP
126% of the activity with thymidine
636844
Drosophila melanogaster
2-chloro-2'-deoxyadenosine 5'-phosphate + ADP
?
3'-azido-2',3'-dideoxythymidine + ATP
636844
Drosophila melanogaster
3'-azido-2',3'-dideoxythymidine 5'-phosphate + ADP
?
5-fluoro-2'-deoxyuridine + ATP
92% of the activity with thymidine
636844
Drosophila melanogaster
5-fluoro-2'-deoxyuridine 5'-phosphate + ADP
?
adenosine + ATP
0.82% of the activity with thymidine
636844
Drosophila melanogaster
adenosine 5'-phosphate + ADP
?
cytidine + ATP
16% of the activity with thymidine
636844
Drosophila melanogaster
cytidine 5'-phosphate + ADP
?
guanosine + ATP
1.18% of the activity with thymidine
636844
Drosophila melanogaster
guanosine 5'-phosphate + ADP
?
thymidine + ATP
636844
Drosophila melanogaster
thymidine 5'-phosphate + ADP
?
uridine + ATP
6.45% of the activity with thymidine
636844
Drosophila melanogaster
uridine 5'-phosphate + ADP
?
0.036
3'-azido-2',3'-dideoxythymidine
Drosophila melanogaster
0.052
3'-azido-2',3'-dideoxythymidine
mutant enzyme N45D/N64D
Drosophila melanogaster
0.076
2'-deoxyguanosine
mutant enzyme N45D/N64D
Drosophila melanogaster
0.54
2',3'-dideoxycytidine
mutant enzyme N45D/N64D
Drosophila melanogaster
0.828
2'-deoxyadenosine
mutant enzyme N45D/N64D
Drosophila melanogaster
1.22
thymidine
mutant enzyme N45D/N64D
Drosophila melanogaster
4.03
2'-deoxycytidine
mutant enzyme N45D/N64D
Drosophila melanogaster
4.2
2',3'-dideoxycytidine
Drosophila melanogaster
14.2
thymidine
pH 7.8, 22°C, recombinant enzyme
Drosophila melanogaster
15.1
2'-deoxyguanosine
pH 7.8, 22°C, recombinant enzyme
Drosophila melanogaster
16.5
2'-deoxycytidine
pH 7.8, 22°C, recombinant enzyme
Drosophila melanogaster
20.6
2'-deoxyadenosine
pH 7.8, 22°C, recombinant enzyme
Drosophila melanogaster
I102M/N117S/M118V/D208N
clones harbouring the mutant enzyme are more sensitive to 3'-azido-2',3'-dideoxythymidine and beta-D-arabinofuranosylcytosine
Drosophila melanogaster
I47T/N210D
clones harbouring the mutant enzyme are more sensitive to 3'-azido-2',3'-dideoxythymidine and beta-D-arabinofuranosylcytosine
Drosophila melanogaster
M1T/T85A/N121S
clones harbouring the mutant enzyme are more sensitive to 1-beta-D-arabinofuranosylcytosine and 2',3'-dideoxycytidine
Drosophila melanogaster
N210D/L239P
clones harbouring the mutant enzyme are more sensitive to 3'-azido-2',3'-dideoxythymidine and beta-D-arabinofuranosylcytosine
Drosophila melanogaster
N38D/N64D
clones harbouring the mutant enzyme are more sensitive specifically to 3'-azido-2',3'-dideoxythymidine
Drosophila melanogaster
N45D/N64D
clones harbouring the mutant enzyme are more sensitive to 3'-azido-2',3'-dideoxythymidine and other nucleoside analogs; mutant enzyme with the largest und universal increase in sensitivity of all mutants tested. 316fold increase to 3'-azido-2',3'-dideoxythymidine, more than 11fold to 2',3'-dideoxycytidine, and 3.2fold increase in sensitivity to beta-D-arabinofuranosylcytosine and 2',3'-dideoxyadenosine. Higher Km-values for native substrates than wild-type enzyme and Vmax-values are substantially lower, decrease in feedback inhibition by TTP, Km and Vmax values for 3'-azido-2',3'-dideoxythymidine and Km value for 2',3'-dideoxycytidine are nearly unchanged
Drosophila melanogaster
N59D/M118V/Y179H
clones harbouring the mutant enzyme are more sensitive to 3'-azido-2',3'-dideoxythymidine and beta-D-arabinofuranosylcytosine
Drosophila melanogaster
N64S/L68S/M69L
clones harbouring the mutant enzyme are more sensitive specifically to 3'-azido-2',3'-dideoxythymidine
Drosophila melanogaster
T12A/V84A/N213S
clones harbouring the mutant enzyme are more sensitive to 1-beta-D-arabinofuranosylcytosine
Drosophila melanogaster
T85A
clones harbouring the mutant enzyme are more sensitive to 1-beta-D-arabinofuranosylcytosine and 2',3'-dideoxycytidine
Drosophila melanogaster
V84A
clones harbouring the mutant enzyme are more sensitive to 1-beta-D-arabinofuranosylcytosine
Drosophila melanogaster
(E)-5-(2-bromovinyl)-2'-deoxyuridine + ATP
54% of the activity with thymidine
636844
Drosophila melanogaster
(E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate + ADP
?
1-beta-D-arabinofuranosylcytosine + ATP
58.2% of the activity with thymidine
636844
Drosophila melanogaster
1-beta-D-arabinofuranosylcytosine 5'-phosphate + ADP
?
1-beta-D-arabinofuranosylthymine + ATP
53.9% of the activity with thymidine
636844
Drosophila melanogaster
1-beta-D-arabinofuranosylthymine 5'-phosphate + ADP
?
2',3'-dideoxyadenosine + ATP
0.9% of the activity with thymidine
636844
Drosophila melanogaster
2',3'-dideoxyadenosine 5'-phosphate + ADP
?
2',3'-dideoxycytidine + ATP
636844
Drosophila melanogaster
2',3'-dideoxycytidine 5'-phosphate + ADP
?
2'-deoxyadenosine + ATP
636844
Drosophila melanogaster
2'-deoxyadenosine 5'-phosphate + ADP
?
2'-deoxycytidine + ATP
636844
Drosophila melanogaster
2'-deoxycytidine 5'-phosphate + ADP
?
2'-deoxyguanosine + ATP
636844
Drosophila melanogaster
2'-deoxyguanosine 5'-phosphate + ADP
?
2'-deoxyuridine + ATP
113% of the activity with thymidine
636844
Drosophila melanogaster
2'-deoxyuridine 5'-phosphate + ADP
?
2-chloro-2'-deoxyadenosine + ATP
126% of the activity with thymidine
636844
Drosophila melanogaster
2-chloro-2'-deoxyadenosine 5'-phosphate + ADP
?
3'-azido-2',3'-dideoxythymidine + ATP
636844
Drosophila melanogaster
3'-azido-2',3'-dideoxythymidine 5'-phosphate + ADP
?
5-fluoro-2'-deoxyuridine + ATP
92% of the activity with thymidine
636844
Drosophila melanogaster
5-fluoro-2'-deoxyuridine 5'-phosphate + ADP
?
adenosine + ATP
0.82% of the activity with thymidine
636844
Drosophila melanogaster
adenosine 5'-phosphate + ADP
?
cytidine + ATP
16% of the activity with thymidine
636844
Drosophila melanogaster
cytidine 5'-phosphate + ADP
?
guanosine + ATP
1.18% of the activity with thymidine
636844
Drosophila melanogaster
guanosine 5'-phosphate + ADP
?
thymidine + ATP
636844
Drosophila melanogaster
thymidine 5'-phosphate + ADP
?
uridine + ATP
6.45% of the activity with thymidine
636844
Drosophila melanogaster
uridine 5'-phosphate + ADP
?
0.036
3'-azido-2',3'-dideoxythymidine
Drosophila melanogaster
0.052
3'-azido-2',3'-dideoxythymidine
mutant enzyme N45D/N64D
Drosophila melanogaster
0.076
2'-deoxyguanosine
mutant enzyme N45D/N64D
Drosophila melanogaster
0.54
2',3'-dideoxycytidine
mutant enzyme N45D/N64D
Drosophila melanogaster
0.828
2'-deoxyadenosine
mutant enzyme N45D/N64D
Drosophila melanogaster
1.22
thymidine
mutant enzyme N45D/N64D
Drosophila melanogaster
4.03
2'-deoxycytidine
mutant enzyme N45D/N64D
Drosophila melanogaster
4.2
2',3'-dideoxycytidine
Drosophila melanogaster
14.2
thymidine
pH 7.8, 22°C, recombinant enzyme
Drosophila melanogaster
15.1
2'-deoxyguanosine
pH 7.8, 22°C, recombinant enzyme
Drosophila melanogaster
16.5
2'-deoxycytidine
pH 7.8, 22°C, recombinant enzyme
Drosophila melanogaster
20.6
2'-deoxyadenosine
pH 7.8, 22°C, recombinant enzyme
Drosophila melanogaster
738739
Kamiya
In vivo selection of active de ...
Drosophila melanogaster
J. Biotechnol.
228
52-57
2016
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1
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1
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1
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-
738781
Slot Christiansen
-
Non-viral deoxyribonucleoside ...
Anopheles gambiae, Bombyx mori, Drosophila melanogaster
J. Genet. Genomics
42
235-248
2015
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2
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1
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3
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3
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33
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7
7
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739211
Jiang
Tanshinone IIA enhances bystan ...
Drosophila melanogaster
Oncol. Rep.
34
1487-1493
2015
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1
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4
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1
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737404
Serra
-
Immobilized Drosophila melanog ...
Drosophila melanogaster
Adv. Synth. Catal.
356
563-570
2014
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1
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1
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1
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14
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1
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703396
Betham
Use of Drosophila deoxynucleos ...
Drosophila melanogaster
DNA Repair
9
153-160
2010
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1
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1
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721775
Ito
Cytotoxic effect of Drosophila ...
Drosophila melanogaster
Biol. Pharm. Bull.
33
1223-1227
2010
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5
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702047
Knecht
Drosophila melanogaster deoxyr ...
Drosophila melanogaster
Biochem. Biophys. Res. Commun.
382
430-433
2009
-
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1
692289
Mikkelsen
Structural studies of nucleosi ...
Drosophila melanogaster
FEBS J.
275
2151-2160
2008
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694476
Clausen
A multisubstrate deoxyribonucl ...
Arabidopsis thaliana
Nucleic Acids Symp. Ser.
52
489-490
2008
-
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673584
Egeblad-Welin
Functional studies of active-s ...
Drosophila melanogaster
FEBS J.
274
1542-1551
2007
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7
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673848
Knecht
Drosophila deoxyribonucleoside ...
Drosophila melanogaster
Gene Ther.
14
1278-1286
2007
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2
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675450
Gerth
Non-homologous recombination o ...
Drosophila melanogaster
J. Mol. Biol.
370
742-751
2007
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676100
Solaroli
Mitochondrial expression of th ...
Drosophila melanogaster
Mol. Pharmacol.
72
1593-1598
2007
-
1
1
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1
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2
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2
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-
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-
-
-
-
-
-
-
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-
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-
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672880
Jordheim
Gemcitabine resistance due to ...
Drosophila melanogaster
Cancer Chemother. Pharmacol.
58
547-554
2006
-
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1
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672971
Legent
In vivo analysis of Drosophila ...
Drosophila melanogaster
Cell Cycle
5
740-749
2006
-
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676247
Kamiya
Transient expression of Drosop ...
Drosophila melanogaster
Nucleosides Nucleotides Nucleic Acids
25
553-560
2006
-
1
1
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661702
Welin
Structural basis for the chang ...
Drosophila melanogaster
FEBS J.
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Animal deoxyribonucleoside kin ...
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662990
Solaroli
Investigation of the substrate ...
Drosophila melanogaster
Nucleosides Nucleotides Nucleic Acids
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2004
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Krawiec
Inorganic tripolyphosphate (PP ...
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2003
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661072
Mikkelsen
Structural basis for feedback ...
Drosophila melanogaster
Biochemistry
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2003
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Solaroli
Active site mutants of Drosoph ...
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Knecht
Mosquito has a single multisub ...
Anopheles gambiae
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2003
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662985
Krawiec
Ability of adenosine-2'(3')-de ...
Drosophila melanogaster
Nucleosides Nucleotides Nucleic Acids
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2003
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661453
Eriksson
Structure and function of cell ...
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661583
Knecht
A few amino acid substitutions ...
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Knecht
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Zheng
Nucleoside analog cytotoxicity ...
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662932
Johansson
Structural basis for substrate ...
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Munch-Petersen
Functional expression of a mul ...
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636843
Balzarini
The multifunctional deoxynucle ...
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Knecht
Identification of residues inv ...
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Johansson
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Munch-Petersen
The single deoxynucleoside kin ...
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Munch-Petersen
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