Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-deoxycytidine | competitive with thymidine | Drosophila melanogaster | |
2'-deoxyguanosine | - |
Drosophila melanogaster | |
thymidine | competitive with 2'-deoxycytidine | Drosophila melanogaster | |
TTP | feed-back inhibition | Drosophila melanogaster |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
thymidine | pH 8.0, 22°C | Drosophila melanogaster | |
0.001 | - |
2'-deoxycytidine | pH 8.0, 22°C | Drosophila melanogaster | |
0.0014 | - |
ATP | pH 8.0, 22°C, reaction with 2'-deoxycytidine | Drosophila melanogaster | |
0.0022 | - |
ATP | pH 8.0, 22°C, reaction with thymidine | Drosophila melanogaster |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29000 | - |
1 * 29000, SDS-PAGE | Drosophila melanogaster |
30000 | - |
gel filtration | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
S-2 | - |
Drosophila melanogaster S-2 | - |
S-2 | - |
Purification (Comment) | Organism |
---|---|
- |
Drosophila melanogaster |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Drosophila melanogaster | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Drosophila melanogaster |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-beta-D-arabinofuranosylcytosine + ATP | 50% of the activity with thymidine and 2'-deoxycytidine | Drosophila melanogaster | 1-beta-D-arabinofuranosylcytosine 5'-phosphate + ADP | - |
? | |
1-beta-D-arabinofuranosylthymine + ATP | 15% of the activity with thymidine and 2'-deoxycytidine | Drosophila melanogaster | 1-beta-D-arabinofuranosylthymine 5'-phosphate + ADP | - |
? | |
2'-deoxyadenosine + ATP | 15% of the activity with thymidine and 2'-deoxycytidine | Drosophila melanogaster | 2'-deoxyadenosine 5'-phosphate + ADP | - |
? | |
2'-deoxycytidine + ATP | - |
Drosophila melanogaster | 2'-deoxycytidine 5'-phosphate + ADP | - |
? | |
2'-deoxycytidine + ATP | - |
Drosophila melanogaster S-2 | 2'-deoxycytidine 5'-phosphate + ADP | - |
? | |
2'-deoxyguanosine + ATP | 4% of the activity with thymidine and 2'-deoxycytidine | Drosophila melanogaster | 2'-deoxyguanosine 5'-phosphate + ADP | - |
? | |
3'-azidothymidine + ATP | 0.3% of the activity with thymidine and 2'-deoxycytidine | Drosophila melanogaster | 3'-azidothymidine 5'-phosphate + ADP | - |
? | |
additional information | no activity with acyclovir | Drosophila melanogaster | ? | - |
? | |
additional information | no activity with TMP | Drosophila melanogaster | ? | - |
? | |
additional information | CTP has the same phosphotransfer capability as ATP | Drosophila melanogaster | ? | - |
? | |
additional information | no activity with acyclovir | Drosophila melanogaster S-2 | ? | - |
? | |
additional information | no activity with TMP | Drosophila melanogaster S-2 | ? | - |
? | |
additional information | CTP has the same phosphotransfer capability as ATP | Drosophila melanogaster S-2 | ? | - |
? | |
thymidine + ATP | - |
Drosophila melanogaster | thymidine 5'-phosphate + ADP | - |
? | |
thymidine + ATP | - |
Drosophila melanogaster S-2 | thymidine 5'-phosphate + ADP | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 29000, SDS-PAGE | Drosophila melanogaster |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Drosophila melanogaster |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
thymidine | pH 8.0, 22°C, competitive with 2'-deoxycytidine | Drosophila melanogaster | |
0.001 | - |
2'-deoxycytidine | pH 8.0, 22°C, competitive with thymidine | Drosophila melanogaster | |
0.005 | - |
TTP | pH 8.0, 22°C | Drosophila melanogaster |