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Literature summary for 2.7.1.143 extracted from

  • Munagala, N.R.; Wang, C.C.
    Adenosine is the primary precursor of all purine nucleotides in Trichomonas vaginalis (2003), Mol. Biochem. Parasitol., 127, 143-149.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Formycin A IC50 is 0.00027 mM, inhibits growth of Trichomonas vaginalis, addition of adenine prevents growth inhibition, but not the addition of guanine and hypoxanthine Trichomonas vaginalis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Trichomonas vaginalis 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diphosphate + adenosine Trichomonas vaginalis
-
phosphate + AMP
-
?
diphosphate + adenosine Trichomonas vaginalis 3001
-
phosphate + AMP
-
?
diphosphate + guanosine Trichomonas vaginalis
-
phosphate + GMP
-
?
diphosphate + guanosine Trichomonas vaginalis 3001
-
phosphate + GMP
-
?
diphosphate + inosine Trichomonas vaginalis
-
phosphate + IMP
-
?
additional information Trichomonas vaginalis adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview ?
-
?
additional information Trichomonas vaginalis 3001 adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Trichomonas vaginalis
-
-
-
Trichomonas vaginalis 3001
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially by ATP affinity chromatography Trichomonas vaginalis

Source Tissue

Source Tissue Comment Organism Textmining
additional information the organism can grow on adenine, but not on guanine or hypoxanthine added to the culture medium Trichomonas vaginalis
-
trophozoite
-
Trichomonas vaginalis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diphosphate + adenosine
-
Trichomonas vaginalis phosphate + AMP
-
?
diphosphate + adenosine
-
Trichomonas vaginalis 3001 phosphate + AMP
-
?
diphosphate + guanosine
-
Trichomonas vaginalis phosphate + GMP
-
?
diphosphate + guanosine
-
Trichomonas vaginalis 3001 phosphate + GMP
-
?
diphosphate + inosine
-
Trichomonas vaginalis phosphate + IMP
-
?
additional information adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview Trichomonas vaginalis ?
-
?
additional information adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview Trichomonas vaginalis 3001 ?
-
?

Synonyms

Synonyms Comment Organism
PNK
-
Trichomonas vaginalis
purine nucleoside kinase
-
Trichomonas vaginalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Trichomonas vaginalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Trichomonas vaginalis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00027
-
IC50 is 0.00027 mM, inhibits growth of Trichomonas vaginalis, addition of adenine prevents growth inhibition, but not the addition of guanine and hypoxanthine Trichomonas vaginalis Formycin A