BRENDA - Enzyme Database show
show all sequences of 2.7.1.143

Adenosine is the primary precursor of all purine nucleotides in Trichomonas vaginalis

Munagala, N.R.; Wang, C.C.; Mol. Biochem. Parasitol. 127, 143-149 (2003)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Formycin A
IC50 is 0.00027 mM, inhibits growth of Trichomonas vaginalis, addition of adenine prevents growth inhibition, but not the addition of guanine and hypoxanthine
Trichomonas vaginalis
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Trichomonas vaginalis
5737
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
diphosphate + adenosine
Trichomonas vaginalis
-
phosphate + AMP
-
-
?
diphosphate + adenosine
Trichomonas vaginalis 3001
-
phosphate + AMP
-
-
?
diphosphate + guanosine
Trichomonas vaginalis
-
phosphate + GMP
-
-
?
diphosphate + guanosine
Trichomonas vaginalis 3001
-
phosphate + GMP
-
-
?
diphosphate + inosine
Trichomonas vaginalis
-
phosphate + IMP
-
-
?
additional information
Trichomonas vaginalis
adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview
?
-
-
-
additional information
Trichomonas vaginalis 3001
adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Trichomonas vaginalis
-
-
-
Trichomonas vaginalis 3001
-
-
-
Purification (Commentary)
Commentary
Organism
partially by ATP affinity chromatography
Trichomonas vaginalis
Source Tissue
Source Tissue
Commentary
Organism
Textmining
additional information
the organism can grow on adenine, but not on guanine or hypoxanthine added to the culture medium
Trichomonas vaginalis
-
trophozoite
-
Trichomonas vaginalis
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
diphosphate + adenosine
-
656748
Trichomonas vaginalis
phosphate + AMP
-
-
-
?
diphosphate + adenosine
-
656748
Trichomonas vaginalis 3001
phosphate + AMP
-
-
-
?
diphosphate + guanosine
-
656748
Trichomonas vaginalis
phosphate + GMP
-
-
-
?
diphosphate + guanosine
-
656748
Trichomonas vaginalis 3001
phosphate + GMP
-
-
-
?
diphosphate + inosine
-
656748
Trichomonas vaginalis
phosphate + IMP
-
-
-
?
additional information
adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview
656748
Trichomonas vaginalis
?
-
-
-
-
additional information
adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview
656748
Trichomonas vaginalis 3001
?
-
-
-
-
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Trichomonas vaginalis
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.2
-
assay at
Trichomonas vaginalis
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00027
-
IC50 is 0.00027 mM, inhibits growth of Trichomonas vaginalis, addition of adenine prevents growth inhibition, but not the addition of guanine and hypoxanthine
Trichomonas vaginalis
Formycin A
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00027
-
IC50 is 0.00027 mM, inhibits growth of Trichomonas vaginalis, addition of adenine prevents growth inhibition, but not the addition of guanine and hypoxanthine
Trichomonas vaginalis
Formycin A
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Formycin A
IC50 is 0.00027 mM, inhibits growth of Trichomonas vaginalis, addition of adenine prevents growth inhibition, but not the addition of guanine and hypoxanthine
Trichomonas vaginalis
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Trichomonas vaginalis
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
diphosphate + adenosine
Trichomonas vaginalis
-
phosphate + AMP
-
-
?
diphosphate + adenosine
Trichomonas vaginalis 3001
-
phosphate + AMP
-
-
?
diphosphate + guanosine
Trichomonas vaginalis
-
phosphate + GMP
-
-
?
diphosphate + guanosine
Trichomonas vaginalis 3001
-
phosphate + GMP
-
-
?
diphosphate + inosine
Trichomonas vaginalis
-
phosphate + IMP
-
-
?
additional information
Trichomonas vaginalis
adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview
?
-
-
-
additional information
Trichomonas vaginalis 3001
adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
partially by ATP affinity chromatography
Trichomonas vaginalis
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
additional information
the organism can grow on adenine, but not on guanine or hypoxanthine added to the culture medium
Trichomonas vaginalis
-
trophozoite
-
Trichomonas vaginalis
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
diphosphate + adenosine
-
656748
Trichomonas vaginalis
phosphate + AMP
-
-
-
?
diphosphate + adenosine
-
656748
Trichomonas vaginalis 3001
phosphate + AMP
-
-
-
?
diphosphate + guanosine
-
656748
Trichomonas vaginalis
phosphate + GMP
-
-
-
?
diphosphate + guanosine
-
656748
Trichomonas vaginalis 3001
phosphate + GMP
-
-
-
?
diphosphate + inosine
-
656748
Trichomonas vaginalis
phosphate + IMP
-
-
-
?
additional information
adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview
656748
Trichomonas vaginalis
?
-
-
-
-
additional information
adenine is the precursor of the entire purine nucleotide pool in Trichomonas vaginalis, the enzyme is involved in replenishing of the purine pool in the organism, probable purine salvage pathway, overview
656748
Trichomonas vaginalis 3001
?
-
-
-
-
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Trichomonas vaginalis
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.2
-
assay at
Trichomonas vaginalis
Other publictions for EC 2.7.1.143
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
656748
Munagala
Adenosine is the primary precu ...
Trichomonas vaginalis, Trichomonas vaginalis 3001
Mol. Biochem. Parasitol.
127
143-149
2003
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1
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7
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3
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7
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1
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1
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7
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1
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2
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7
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1
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1
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645030
McElwain
-
Purine and pyrimidine metaboli ...
Anaeroplasma intermedium, Mycoplasma hominis, no activity in Acholeplasma florum, no activity in Mycoplasma arginini, no activity in Mycoplasma bovigenitalium, no activity in Mycoplasma gallisepticum, no activity in Mycoplasma genitalium, no activity in Mycoplasma hyopneumoniae, no activity in Mycoplasma pneumoniae, no activity in Spiroplasma floricola, no activity in Ureaplasma urealyticum, Spiroplasma citri
Int. J. Syst. Bacteriol.
38
417-423
1988
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12
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3
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3
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645031
Tyron
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Distinction in mollicutes puri ...
Acholeplasma axanthum, Acholeplasma granularum
Int. J. Syst. Bacteriol.
35
497-501
1985
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2
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3
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3
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-
-
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645029
Tyron
Purine metabolism in acholepla ...
Acholeplasma laidlawii, Acholeplasma laidlawii B-PG9
J. Bacteriol.
159
265-270
1984
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2
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8
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8
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2
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8
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