Literature summary for 2.7.1.14 extracted from

Haschemi, A.; Kosma, P.; Gille, L.; Evans, C.R.; Burant, C.F.; Starkl, P.; Knapp, B.; Haas, R.; Schmid, J.A.; Jandl, C.; Amir, S.; Lubec, G.; Park, J.; Esterbauer, H.; Bilban, M.; Brizuela, L.; Pospisilik, J.A.; Otterbein, L.E.; Wagner, O.
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism (2012), Cell Metab., 15, 813-826.

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Cloned(Commentary)

Cloned (Comment)	Organism
recombinantly expressed in Escherichia coli	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
Q126K	mutant shows substantially reduced sedoheptulose kinase activity	Mus musculus
T14M/T15K	mutant shows substantially reduced sedoheptulose kinase activity	Mus musculus
W125D	mutant shows substantially reduced sedoheptulose kinase activity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + sedoheptulose	-	Mus musculus	ADP + sedoheptulose 7-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
carbohydrate kinase-like protein	-	Mus musculus
CARKL	-	Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.6	-	assay at	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	rapidly downregulated in vitro and in vivo upon lipopolysaccharide	down

General Information

General Information	Comment	Organism
physiological function	using a screening strategy novel regulators of macrophage activation are identified. CARKL-dependent metabolic reprogramming is required for proper M1- and M2- like macrophage polarization and uncovers a ratelimiting requirement for appropriate glucose flux in macrophage polarization	Mus musculus

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Release 2023.1 (January 2023)