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Literature summary for 2.7.1.138 extracted from

  • Yu, J.; Kim, H.M.; Kim, K.P.; Son, Y.; Kim, M.S.; Park, K.S.
    Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells (2019), Biochem. Biophys. Res. Commun., 508, 361-367 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-[2-(benzoylamino)-6-benzothiazolyl]-tricyclo[3.3.1.13,7] decane-1-carboxamide NVP-231 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Mus musculus
-
ADP + ceramide 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K4Q7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mesenchymal stem cell bone marrow-derived mesenchymal stem cells, BM-MSCs Mus musculus
-
ST-2 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
Mus musculus ADP + ceramide 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
CERK
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

General Information

General Information Comment Organism
malfunction a specific inhibitor of ceramide kinase inhibits TGF-beta-induced migration of BM-MSCs and N-cadherin that is necessary for BM-MSCs migration in response to TGF-beta Mus musculus
physiological function endogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) are mobilized into peripheral blood and injured tissues by various growth factors and cytokines that are expressed in the injured tissues, such as substance P (SP), stromal cell derived factor-1 (SDF-1), and transforming growth factor beta (TGF-beta). Extracellular bioactive lipid metabolites such as ceramide 1-phosphate and sphingosine 1-phosphate also modulate BM-MSC migration as SP, SDF-1, and TGF-beta. Ceramide kinase mediates the chemotactic migration of BM-MSCs in response to SP, SDF-1, or TGF-beta. Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells. The extracellular ceramide 1-phosphate regulates the migration of bone marrowderived multipotent mesenchymal stem cells (BM-MSCs) as well as macrophages, lung cancer cells, prostate cancer cells, and endothelial cells. Ceramide 1-phosphate generated by ceramide kinase is released extracellularly in order to induce cellular migration. Ceramide 1-phosphate also remains inside of cells in order to recruit cytosolic proteins and transduce signals. Ceramide kinase also regulates the expression of N-cadherin that is required for BM-MSCs migration induced by TGF-beta Mus musculus