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Literature summary for 2.7.1.138 extracted from

  • Simanshu, D.K.; Kamlekar, R.K.; Wijesinghe, D.S.; Zou, X.; Zhai, X.; Mishra, S.K.; Molotkovsky, J.G.; Malinina, L.; Hinchcliffe, E.H.; Chalfant, C.E.; Brown, R.E.; Patel, D.J.
    Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids (2013), Nature, 500, 463-467.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.138

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane CERK also contains nuclear localization/export signals and traffics to the plasma membrane via microtubule-driven vesicles in response to hyperosmotic shock Homo sapiens 5886
-
trans-Golgi network phosphorylation of ceramide by CERK at the cytoplasmic surface of the trans-Golgi network Homo sapiens 5802
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Homo sapiens
-
 ADP + ceramide 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TCT0 gene CERK
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
 Homo sapiens ADP + ceramide 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CERK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function phosphorylated sphingolipids ceramide-1-phosphate and sphingosine-1-phosphate are key regulators of cell growth, survival, migration, and inflammation. Ceramide 1-phosphate produced by ceramide kinase is an activator of group IVA cytosolic phospholipase A2alpha (cPLA2alpha), the rate-limiting releaser of arachidonic acid used for pro-inflammatory eicosanoid production, which contributes to disease pathogenesis in asthma/airway hyper-responsiveness, cancer, atherosclerosis, and thrombosis. To modulate eicosanoid action and avoid the damaging effects of chronic inflammation, cells require efficient targeting, trafficking, and presentation of ceramide 1-phosphate to specific cellular sites. Nonvesicular trafficking by a ceramide-1-phosphate transfer protein, CPTP, regulates eicosanoids, mechanism, overview. CPTP prevents excess ceramide-1-phosphate accumulation after production by CERK, thereby regulating cPLA2alpha action, diminishing arachidonic acid release and downstream generation of pro-inflammatory eicosanoids Homo sapiens