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Literature summary for 2.7.1.138 extracted from

  • Niwa, S.; Graf, C.; Bornancin, F.
    Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro (2009), Microvasc. Res., 77, 389-393.
    View publication on PubMed
Search for more literature for 2.7.1.138

Inhibitors

Inhibitors Comment Organism Structure
NVP-231 potent inhibition of ceramide kinase catalyzed production of ceramide 1-phosphate both in vitro and in cell-based assays Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ceramide Mus musculus
-
 ADP + ceramide 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dermal microvascular endothelial cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
 Mus musculus ADP + ceramide 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ceramide kinase
-
 Mus musculus
CERK
-
 Mus musculus

General Information

General Information Comment Organism
malfunction capillary-like tube formation is significantly impaired in CerK-deficient cells or in wild type cells treated with NVP-231 as compared with untreated wild type cells, ceramide kinase ablation increases serum ceramide levels at the expense of dihydroceramide levels without affecting sphingosine, dihydrosphingosine, sphingosine-1-phosphate or dihydrosphingosine-1-phosphate levels, in both Cerk -/- and NVP-231-treated cells, the density of the cell monolayer area is in increased at the expense of the tube forming area Mus musculus
physiological function ceramide kinase catalyzed formation of ceramide 1-phosphate may regulate angiogenesis by a novel mechanism that is independent of sphingosine-1-phosphate formation and signaling Mus musculus