Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | ceramide is transported to the Golgi complex for phosphorylation by ceramide kinase | Mus musculus | 5794 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the intracellular calcium chelator BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid) decreases ceramide 1-phosphate formation by almost 100%, demonstrating the total dependence of ceramide kinase on Ca2+-ions | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + ATP | Mus musculus | ceramide 1-phosphate is a sphingolipid that participates in cell signaling, but ceramide kinase is not the only source of ceramide 1-phosphate | ceramide 1-phosphate + ADP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
femur | extraction of bone marrow and preparation of macrophages | Mus musculus | - |
macrophage | bone marrow-derived macrophage, BMDM | Mus musculus | - |
primary cell | bone marrow-derived macrophage, BMDM | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + ATP | - |
Mus musculus | ceramide 1-phosphate + ADP | - |
? | |
ceramide + ATP | ceramide 1-phosphate is a sphingolipid that participates in cell signaling, but ceramide kinase is not the only source of ceramide 1-phosphate | Mus musculus | ceramide 1-phosphate + ADP | - |
? | |
N-((4-(4,4-difluoro-5-(2-thienyl)-4-bora-3alpha,4alpha-diaza-s-indacene-3-yl)phenoxy)acetyl)sphingosine + ATP | TRB-ceramide | Mus musculus | N-((4-(4,4-difluoro-5- (2-thienyl)-4- bora-3a,4a-diaza-s-indacene-3-yl)phenoxy)acetyl)sphingosine 1-phosphate + ADP | - |
? | |
N-(5-(5,7-dimethyl-BODIPY)-L-pentanoyl)-D-erythrosphingosine + ATP | DMB-C5 ceramide | Mus musculus | N-(5-(5,7-dimethyl-BODIPY)-L-pentanoyl)-D-erythrosphingosine 1-phosphate + ADP | - |
? | |
N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl-D-erythrosphingosine + ATP | NBD-Cer, NBD-C6 ceramide | Mus musculus | N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl-D-erythrosphingosine 1-phosphate + ADP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CERK | - |
Mus musculus |