Literature summary for 2.7.1.138 extracted from

  • Lamour, N.F.; Stahelin, R.V.; Wijesinghe, D.S.; Maceyka, M.; Wang, E.; Allegood, J.C.; Merrill, A.H.; Cho, W.; Chalfant, C.E.
    Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis (2007), J. Lipid Res., 48, 1293-1304.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane
-
Homo sapiens
-
-
mitochondrion
-
Homo sapiens
-
-
membrane
-
Homo sapiens
-
-
Golgi apparatus
-
Homo sapiens
-
-
endosome membrane
-
Homo sapiens
-
-
trans-Golgi network
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
62000
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + ATP Homo sapiens ceramide kinase is a critical mediator of eicosanoid synthesis, and its product, ceramide 1-phosphate, is required for the production of prostaglandins in response to several inflammatory agonists, CERK requires ceramide actively transported to the trans-Golgi network via ceramide transport protein CERT ceramide 1-phosphate + ADP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
A-549 cell
-
Homo sapiens
-
lung adenocarcinoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ceramide
-
Homo sapiens ADP + ceramide 1-phosphate
-
?
ATP + D-eythro-C16:0 ceramide
-
Homo sapiens ADP + D-eythro-C16:0 ceramide 1-phosphate
-
?
ATP + D-eythro-C18:0 ceramide
-
Homo sapiens ADP + D-eythro-C18:0 ceramide 1-phosphate
-
?
ATP + D-eythro-C20:0 ceramide
-
Homo sapiens ADP + D-eythro-C20:0 ceramide 1-phosphate
-
?
ceramide + ATP
-
Homo sapiens ceramide 1-phosphate + ADP
-
?
ceramide + ATP ceramide kinase is a critical mediator of eicosanoid synthesis, and its product, ceramide 1-phosphate, is required for the production of prostaglandins in response to several inflammatory agonists, CERK requires ceramide actively transported to the trans-Golgi network via ceramide transport protein CERT Homo sapiens ceramide 1-phosphate + ADP
-
?

Synonyms

Synonyms Comment Organism
CERK
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens