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Literature summary for 2.7.1.138 extracted from
- Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles (1989), J. Biol. Chem., 264, 14354-14360.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.004 | - |
stearoylceramide | pH 7.4, 30°C, without Ca2+ | Rattus norvegicus |  |
| 0.009 | - |
stearoylceramide | pH 7.4, 30°, in the presence of 0.010 mM Ca2+ | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| synaptic vesicle membrane | - |
Rattus norvegicus | 30672 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 0.0001-0.0005 mM, 15-20fold increase in activity, 0.0005 mM, 60fold stimulation | Rattus norvegicus | |
| Mg2+ | millimolar concentrations, 20fold stimulation | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ceramide | Rattus norvegicus | ceramide phosphorylation may be associated with neurotransmitter release | ADP + ceramide 1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ceramide | other name n-acyl-sphingosine, no activity with CTP, CDPcholine and UDPglucose | Rattus norvegicus | ADP + ceramide 1-phosphate | - |
? | |
| ATP + ceramide | ceramide phosphorylation may be associated with neurotransmitter release | Rattus norvegicus | ADP + ceramide 1-phosphate | - |
? | |
| ATP + stearoylceramide | - |
Rattus norvegicus | ADP + stearoylceramide 1-phosphate | - |
? | |
| GTP + ceramide | 26% of the activity with ATP at 1 mM | Rattus norvegicus | GDP + ceramide 1-phosphate | - |
? | |
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Release 2023.1 (January 2023)
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