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Literature summary for 2.7.1.137 extracted from

  • Liu, J.; Ji, Y.; Zhou, J.; Xing, D.
    Phosphatidylinositol 3-kinase promotes activation and vacuolar acidification and delays methyl jasmonate-induced leaf senescence (2016), Plant Physiol., 170, 1714-1731.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.137

Inhibitors

Inhibitors Comment Organism Structure
1-((3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)methyl)guanidine i.e. idelalisib Arabidopsis thaliana
LY294002 competes with ATP and binds to Lys residues in the ATP-binding pocket of PI3Ks Arabidopsis thaliana
Wortmannin
-
 Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol Arabidopsis thaliana
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?
additional information Arabidopsis thaliana PI3K binds to the V-ATPase subunit B2 (VHA-B2) in vitro and in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana P42339 gene AtVPS34
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Arabidopsis thaliana ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?
additional information PI3K binds to the V-ATPase subunit B2 (VHA-B2) in vitro and in vivo Arabidopsis thaliana ?
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 3-kinase
-
 Arabidopsis thaliana
PI3K type III
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
evolution PI3K type III is the only type of PI3K identified in plants Arabidopsis thaliana
malfunction treatment with PI3K inhibitors or downregulation of AtVPS34 gene expression further suppressed V-ATPase activation in methyl jasmonate-induced leaf senescence. Downregulation of PI3K activity accelerates methyl jasmonate-induced leaf senescence. Vacuolar pH and the stomatal aperture also increased in the pi3k mutant and in treatments with PI3K inhibitors Arabidopsis thaliana
physiological function phosphatidylinositol 3-kinase, PI3K, binds to VHA-B2 and promotes the activation of V-ATPase, resulting in vacuolar acidification and stomatal closure, thereby delaying methyl jasmonate-induced leaf senescence. PI3K is involved in the regulation of dark-induced senescence but does not function through the regulation of V-ATPase activity. PI3K regulates the activity of V-ATPase in MeJA-induced leaf senescence but not in dark-induced leaf senescence Arabidopsis thaliana