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Literature summary for 2.7.1.137 extracted from

  • Venkatareddy, M.; Verma, R.; Kalinowski, A.; Patel, S.R.; Shisheva, A.; Garg, P.
    Distinct requirements for vacuolar protein sorting 34 downstream effector phosphatidylinositol 3-phosphate 5-kinase in podocytes versus proximal tubular cells (2016), J. Am. Soc. Nephrol., 27, 2702-2719.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.137

Localization

Localization Comment Organism GeneOntology No. Textmining
vacuole
-
 Homo sapiens 5773
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NEB9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
podocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
class 3 phosphatidylinositol 3-kinase vacuolar protein sorting 34
-
 Homo sapiens
PtdIns 3-kinase vacuolar protein sorting 34
-
 Homo sapiens
VPS34
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction deletion of a key endosomal trafficking regulator, the class 3 phosphatidylinositol (PtdIns) 3-kinase vacuolar protein sorting 34 (Vps34), in podocytes results in aberrant endosomal membrane morphology and podocyte dysfunction. The vacuolation phenotype in cultured Vps34-deficient podocytes is caused by the absence of a substrate for the Vps34 downstream effector PtdIns 3-phosphate 5-kinase, which phosphorylates Vps34-generated PtdIns(3)P to produce PtdIns (3,5)P2 Homo sapiens