Literature summary for 2.7.1.137 extracted from

Zheng, W.; Gorre, N.; Shen, Y.; Noda, T.; Ogawa, W.; Lundin, E.; Liu, K.
Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis (2010), EMBO Rep., 11, 890-895.

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Protein Variants

Protein Variants	Comment	Organism
D743N	kinase-dead catalytic loop mutant	Homo sapiens
L750M	mutation in the ATP-binding pocket. Mutant is less sensitive to inhibition by KU55933 than wild-type, mutant is similarly sensitive to inhibition by LY294002 as wild-type	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Gö6976	inhibitor directly targets phosphatidylinositol 3-kinase and confers profound inhibition of autophagic flux by inhibiting the formation of autophagosomes. It does not inhibit the cell survival promoting class I phosphoinositide 3-kinase-Akt signaling at the concentrations required for effective autophagy inhibition	Homo sapiens
KU55933	inhibitor directly targets phosphatidylinositol 3-kinase and confers profound inhibition of autophagic flux by inhibiting the formation of autophagosomes. Inhibits wild-type activity in vitro almost as efficiently as LY294002. It does not inhibit the cell survival promoting class I phosphoinositide 3-kinase-Akt signaling at the concentrations required for effective autophagy inhibition	Homo sapiens
LY294002	inhibits wild-type activity in vitro almost as efficiently as KU55933, but is required at much higher concentrations for efficient inhibition of autophagy	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8NEB9	catalytic subunit type 3	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
VPS34	-	Homo sapiens

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Release 2023.1 (January 2023)