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Literature summary for 2.7.1.137 extracted from

  • Fernandes, A.F.; Bian, Q.; Jiang, J.K.; Thomas, C.J.; Taylor, A.; Pereira, P.; Shang, F.
    Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells (2009), Mol. Biol. Cell, 20, 3690-3699.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
p38 mitogen-activated protein kinase activates PI3K, and proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation in retinal piment epithelial cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ARPE-19 cell
-
 Homo sapiens
-
retinal pigment epithelium cell line
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PI3K
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism a signaling network regulates interleukin-8 production in response to proteasome activation or inactivation also involving PI3K, detailed overview Homo sapiens
physiological function PI3K activity is involved in interleukin-8 production in retinal pigment epithelial cells, independent of 3-phosphoinositide-dependent protein kinase 1, PDK1, and Akt Homo sapiens