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Literature summary for 2.7.1.137 extracted from

  • Itakura, E.; Kishi, C.; Inoue, K.; Mizushima, N.
    Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG (2008), Mol. Biol. Cell, 19, 5360-5372.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
stable expression of GFP-tagged Atg14 in NIH3T3 cells, transient co-expression of N-terminally Myc-, HA-, or FLAG-tagged Atg14, Beclin 1, and UVRAG in HEK-293T cells Homo sapiens
transient co-expression of N-terminally Myc-, HA-, or FLAG-tagged Beclin 1 in HEK-293T cells Homo sapiens
transient co-expression of N-terminally Myc-, HA-, or FLAG-tagged UVRAG in HEK-293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information silencing by siRNA-mediated knockdown of Atg14 in HeLa cells suppresses autophagosome formation Homo sapiens
additional information silencing by siRNA-mediated knockdown of UVRAG in HeLa cells suppresses autophagosome formation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
Homo sapiens 5768
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membrane
-
Homo sapiens 16020
-
additional information Atg14 is present on autophagic isolation membranes Homo sapiens
-
-
additional information UVRAG primarily associates with Rab9-positive endosomes Homo sapiens
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes
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Homo sapiens Q6ZNE5 Atg14; Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes
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Homo sapiens Q9P2Y5 UVRAG; Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy Homo sapiens ?
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?
additional information PI3-kinase activity is not required for starvation-induced Atg14 puncta formation Homo sapiens ?
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?

Subunits

Subunits Comment Organism
More Vps34 contains three distinct domains: the N-terminal C2 domain, central accessory domain and C-terminal catalytic domain Homo sapiens

Synonyms

Synonyms Comment Organism
class III phosphatidylinositol 3-kinase
-
Homo sapiens
PI3-kinase
-
Homo sapiens

General Information

General Information Comment Organism
metabolism mammalian cells have at least two distinct class III PI3-kinase complexes, which may function in different membrane trafficking pathways Homo sapiens