Literature summary for 2.7.1.137 extracted from

Pezet, S.; Marchand, F.; DMello, R.; Grist, J.; Clark, A.K.; Malcangio, M.; Dickenson, A.H.; Williams, R.J.; McMahon, S.B.
Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions (2008), J. Neurosci., 28, 4261-4270.

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Inhibitors

Inhibitors	Comment	Organism	Structure
LY294002	i.e. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, a potent PI3K inhibitor, in vitro and vivo inhibition. Spinal application of LY294002 reduces the wind-up of deep dorsal WDR neurons and inhibits electrically evoked responses. Electrically evoked substance P release is not inhibited by LY294002	Rattus norvegicus
Wortmannin	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + Akt1	Rattus norvegicus	phosphorylation at Ser473, a step in PI3K/Akt signaling	ADP + Akt1 phosphate	-	?
additional information	Rattus norvegicus	PI3K is implicated in the phosphorylation of ERK and CaMKII in spinal neurons, and of NR2B subunits of the NMDA receptor, as well as in the increased synthesis of c-Fos and the trafficking of AMPA-R GluR1 subunit, all after formalin injection	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	adult male Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	-	Rattus norvegicus	-
spinal cord	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + Akt1	phosphorylation at Ser473	Rattus norvegicus	ADP + Akt1 phosphate	-	?
ATP + Akt1	phosphorylation at Ser473, a step in PI3K/Akt signaling	Rattus norvegicus	ADP + Akt1 phosphate	-	?
additional information	PI3K is implicated in the phosphorylation of ERK and CaMKII in spinal neurons, and of NR2B subunits of the NMDA receptor, as well as in the increased synthesis of c-Fos and the trafficking of AMPA-R GluR1 subunit, all after formalin injection	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
PI3K	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	phosphatidylinositol 3-kinase is a key mediator of central sensitization, induced by intraplantar formalin, the spinal cord phenomenon associated with persistent afferent inputs and contributing to chronic pain states, in painful inflammatory conditions	Rattus norvegicus

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Release 2023.1 (January 2023)