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Literature summary for 2.7.1.137 extracted from

  • Ding, Y.; Choi, K.J.; Kim, J.H.; Han, X.; Piao, Y.; Jeong, J.H.; Choe, W.; Kang, I.; Ha, J.; Forman, H.J.; Lee, J.; Yoon, K.S.; Kim, S.S.
    Endogenous hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of phosphatidylinositol 3-kinase during muscle differentiation (2008), Am. J. Pathol., 172, 1529-1541.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information PI 3-kinase activity is not affected by Nrf2 knockdown. Overexpression of DELTAp85 inhibits the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
PI 3-kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function involvement of PI 3-kinase in the Nrf2 pathway during muscle differentiation. Nrf2 is transcriptionally up-regulated and translocated to the nucleus during myogenesis, but does not affect the PI 3-kinase activity acting downstream of it, overview Homo sapiens