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Literature summary for 2.7.1.137 extracted from

  • Shen, J.; Jiang, J.; Wei, Y.; Zhou, L.; Liu, D.; Zhou, J.; Gu, J.
    Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis (2007), Mol. Cell. Biochem., 304, 361-367.
    View publication on PubMed

Application

Application Comment Organism
medicine PI3K inhibitors might have therapeutic potential when combined with cycloheximide in the treatment of hepatoma Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002 the specific inhibitor of the phosphatidylinositol 3-kinase upregulates beta1,4-galactosyltransferase I and thus sensitizes SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. PI3K inhibitors might have therapeutic potential when combined with cycloheximide in the treatment of hepatoma Homo sapiens
Wortmannin the specific inhibitor of the phosphatidylinositol 3-kinase upregulates beta1,4-galactosyltransferase I and thus sensitizes SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. PI3K inhibitors might have therapeutic potential when combined with cycloheximide in the treatment of hepatoma Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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