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Literature summary for 2.7.1.137 extracted from

  • Mostefai, H.A.; Agouni, A.; Carusio, N.; Mastronardi, M.L.; Heymes, C.; Henrion, D.; Andriantsitohaina, R.; Martinez, M.C.
    Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells (2008), J. Immunol., 180, 5028-5035.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information microparticles, membrane vesicles released during cell activation and apoptosis, activate pathways related to NO and reactive oxygen species productions through PI3K, xanthine oxidase, and NF-kappaB pathways, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PI3K
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells. PI3K inhibition reduces the effects of microparticles on endothelial NO synthase, but not on caveolin-1, whereas it enhances the effects of microparticles on reactive oxygen species production. Microparticles stimulated ERK1/2 phosphorylation via a PI3K-depedent mechanism Homo sapiens