Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | microparticles, membrane vesicles released during cell activation and apoptosis, activate pathways related to NO and reactive oxygen species productions through PI3K, xanthine oxidase, and NF-kappaB pathways, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LY294002 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells. PI3K inhibition reduces the effects of microparticles on endothelial NO synthase, but not on caveolin-1, whereas it enhances the effects of microparticles on reactive oxygen species production. Microparticles stimulated ERK1/2 phosphorylation via a PI3K-depedent mechanism | Homo sapiens |