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Literature summary for 2.7.1.137 extracted from

  • Johnson, E.E.; Overmeyer, J.H.; Gunning, W.T.; Maltese, W.A.
    Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes (2006), J. Cell Sci., 119, 1219-1232.
    View publication on PubMed
Search for more literature for 2.7.1.137

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidylinositol Homo sapiens hVps34 plays a major role in generating phosphatidylinositol 3-phosphate for internal vesicle formation in multivesicular/late endosomes. The findings also unexpectedly suggest that other wortmannin-sensitive kinases and/or polyphosphoinositide phosphatases may be able to compensate for the loss of hVps34 and maintain phosphatidylinositol 3-phosphate levels required for vesicular trafficking in the early endocytic pathway or the trans-Golgi network ADP + phosphatidylinositol 3-phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NEB9
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Source Tissue

Source Tissue Comment Organism Textmining
U-251 cell glioblastoma cell Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
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 Homo sapiens ADP + phosphatidylinositol 3-phosphate
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 ?
ATP + 1-phosphatidylinositol hVps34 plays a major role in generating phosphatidylinositol 3-phosphate for internal vesicle formation in multivesicular/late endosomes. The findings also unexpectedly suggest that other wortmannin-sensitive kinases and/or polyphosphoinositide phosphatases may be able to compensate for the loss of hVps34 and maintain phosphatidylinositol 3-phosphate levels required for vesicular trafficking in the early endocytic pathway or the trans-Golgi network Homo sapiens ADP + phosphatidylinositol 3-phosphate
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 ?

Synonyms

Synonyms Comment Organism
hVps34
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 Homo sapiens
type III phosphatidylinositol 3-kinase
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 Homo sapiens