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Literature summary for 2.7.1.137 extracted from

  • Tang, X.; Downes, C.P.
    Purification and characterization of Gbg-responsive phosphoinositide 3-kinases from pig platelet cytosol (1997), J. Biol. Chem., 272, 14193-14199.
    View publication on PubMed
Search for more literature for 2.7.1.137

Inhibitors

Inhibitors Comment Organism Structure
LY294002 IC50 values: 2 mM Sus scrofa
Wortmannin IC50: 10 nM Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
10
-
 phosphatidylinositol 4-phosphate
-
 Sus scrofa
15
-
 phosphatidylinositol 4,5-bisphosphate
-
 Sus scrofa
25
-
 ATP reaction with phosphatidylinositol Sus scrofa
37
-
 ATP reaction with phosphatidylinositol 4,5-diphosphate Sus scrofa
44
-
 ATP reaction with phosphatidylinositol 4-phosphate Sus scrofa
64
-
 phosphatidylinositol
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Sus scrofa 5829
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
 Sus scrofa ADP + phosphatidylinositol 3-phosphate
-
 ?
ATP + phosphatidylinositol 4,5-bisphosphate
-
 Sus scrofa ADP + phosphatidylinositol 3,4,5-trisphosphate
-
 ?
ATP + phosphatidylinositol 4-phosphate
-
 Sus scrofa ADP + phosphatidylinositol 3,4-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
p110g-related PI 3-kinase
-
 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
 IC50: 10 nM Sus scrofa Wortmannin
2
-
 IC50 values: 2 mM Sus scrofa LY294002