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Literature summary for 2.7.1.137 extracted from

  • Hardy, S.; Langelier, Y.; Prentki, M.
    Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects (2000), Cancer Res., 60, 6353-6358.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
oleate activates Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002
-
 Homo sapiens
palmitate
-
 Homo sapiens
Wortmannin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is implicated in the control of breast cancer cell growth by free fatty acids and may provide a link between fat and cancer ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture breast cancer cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?
additional information the enzyme is implicated in the control of breast cancer cell growth by free fatty acids and may provide a link between fat and cancer Homo sapiens ?
-
 ?