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Literature summary for 2.7.1.137 extracted from

  • Beckwith, M.; Fenton, R.G.; Katona, I.M.; Longo, D.L.
    Phosphatidylinositol-3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human b-lymphoma cell line (1996), Blood, 87, 202-210.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information both anti-IgM and anti-IgD stimulation results in an increase in the anti-phosphotyrosine-precipitable PI3K activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Wortmannin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens activation of PI3K is a critical component of the anti-Ig-initiated signaling cascade that leads to growth inhibition of human B lymphoma cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Homo sapiens
-
cell culture B lymphoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?
additional information activation of PI3K is a critical component of the anti-Ig-initiated signaling cascade that leads to growth inhibition of human B lymphoma cells Homo sapiens ?
-
 ?