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Literature summary for 2.7.1.137 extracted from
- Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2 (2002), Mol. Endocrinol., 16, 1612-1628.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| leptin | 1-5 nmol/L stimulates insulin receptor substrate-2 by 280-954% and its associated phosphatidylinositol-3 kinase activity 122-621%. 0.5-25 nmol/L inhibits IRS-1 pY and its associated phosphatidylinositol-3 kinase activity by 20-89% | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidylinositol | - |
Rattus norvegicus | ADP + phosphatidylinositol 3-phosphate | - |
? |  |
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Release 2023.1 (January 2023)
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