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Literature summary for 2.7.1.137 extracted from

  • Shibasaki, F.; Homma, Y.; Takenawa, T.
    Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form (1991), J. Biol. Chem., 266, 8108-8114.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ 0.1 mM, 60% inhibition, in presence of 10 mM MgCl2 Bos taurus
Dodecyl sucrose
-
Bos taurus
Nonidet P40
-
Bos taurus
octylglucoside
-
Bos taurus
sodium cholate
-
Bos taurus
sodium deoxycholate
-
Bos taurus
Triton X-100
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Bos taurus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ CaCl2 stimulates enzyme forms PI3KI and PI3KII in absence of MnCl2. Half-maximal activation of PI3KI at 0.1 mM Ca2+, maximal activity at 1 mM, in presence of 10 mM MgCl2 further 2fold activation by 2 mM Ca2+. For PI3KII maximal activity is obtained in presence of 2 mM Ca2+, 1.6fold higher than that obtained in presence of 10 mM MgCl2 Bos taurus
Mg2+ maximal activation at 5 mM Bos taurus
Mg2+ activation Bos taurus
Mn2+ scarcely activates Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
1 * 110000 + 1 * 85000, enzyme form PI3KII, SDS-PAGE Bos taurus
110000
-
monomeric form PI3KI, gel filtration Bos taurus
190000
-
heterodimeric form PI3KII, gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
PI3KI, monomeric form Bos taurus
PI3KII, heterodimeric form Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.05
-
dimeric enzyme form PI3KII Bos taurus
0.25
-
monomeric enzyme form PI3KI Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
Bos taurus ADP + phosphatidylinositol 3-phosphate
-
?

Subunits

Subunits Comment Organism
dimer 1 * 110000 + 1 * 85000, enzyme form PI3KII, SDS-PAGE Bos taurus
monomer 1 * 110000, enzyme form PI3KI, SDS-PAGE Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
enzyme forms PI3KII and PI3KI Bos taurus