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Literature summary for 2.7.1.134 extracted from

  • Yang, X.; Shears, B.S.
    Multitasking in signal transduction by a promiscuous human ins(3,4,5,6)P4 1-kinase/ins(1,3,4)P3 5/6-kinase (2000), Biochem. J., 351, 551-555.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
S356N same catalytic activity as wild-type Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0001
-
myo-inositol-3,4,5,6-tetrakisphosphate pH 7.2, 37°C, recombinant enzyme Homo sapiens
0.0002
-
myo-inositol-3,4,6-trisphosphate pH 7.2, 37°C, recombinant enzyme Homo sapiens
0.0003
-
myo-inositol-1,3,4-trisphosphate pH 7.2, 37°C, recombinant enzyme Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
x * 47000, deduced from nucleotide sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13572
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate enzyme has both inositol-3,4,5,6-tetrakisphosphate 1-kinase and inositol-1,3,4-trisphosphate 5/6 kinase activity, 2 times higher activity than with inositol-1,3,4-trisphosphate, no activity with inositol-1,4-bisphosphate, inositol-1,4,5-trisphosphate, inositol-1,3,4,5-tetrakisphosphate, inositol-1,3,4,6-tetrakisphosphate or inositol-1,3,4,5,6-pentakisphosphate Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
?
ATP + myo-inositol-3,4,6-trisphosphate
-
Homo sapiens ADP + myo-inositol-1,3,4,6-tetrakisphosphate
-
?

Subunits

Subunits Comment Organism
? x * 47000, deduced from nucleotide sequence Homo sapiens