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Literature summary for 2.7.1.134 extracted from

  • Yang, X.; Shears, B.S.
    Multitasking in signal transduction by a promiscuous human ins(3,4,5,6)P4 1-kinase/ins(1,3,4)P3 5/6-kinase (2000), Biochem. J., 351, 551-555.
No PubMed abstract available
Search for more literature for 2.7.1.134

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
S356N same catalytic activity as wild-type Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0001
-
 myo-inositol-3,4,5,6-tetrakisphosphate pH 7.2, 37°C, recombinant enzyme Homo sapiens
0.0002
-
 myo-inositol-3,4,6-trisphosphate pH 7.2, 37°C, recombinant enzyme Homo sapiens
0.0003
-
 myo-inositol-1,3,4-trisphosphate pH 7.2, 37°C, recombinant enzyme Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
 x * 47000, deduced from nucleotide sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13572
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate enzyme has both inositol-3,4,5,6-tetrakisphosphate 1-kinase and inositol-1,3,4-trisphosphate 5/6 kinase activity, 2 times higher activity than with inositol-1,3,4-trisphosphate, no activity with inositol-1,4-bisphosphate, inositol-1,4,5-trisphosphate, inositol-1,3,4,5-tetrakisphosphate, inositol-1,3,4,6-tetrakisphosphate or inositol-1,3,4,5,6-pentakisphosphate Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
ATP + myo-inositol-3,4,6-trisphosphate
-
 Homo sapiens ADP + myo-inositol-1,3,4,6-tetrakisphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 47000, deduced from nucleotide sequence Homo sapiens