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Literature summary for 2.7.1.134 extracted from

  • Craxton, A.; Erneux, C.; Shears, S.B.
    Inositol 1,4,5,6-tetrakisphosphate is phosphorylated in rat liver by a 3-kinase that is distinct from inositol 1,4,5-trisphosphate 3-kinase (1994), J. Biol. Chem., 269, 4337-4342.
    View publication on PubMed
Search for more literature for 2.7.1.134

Inhibitors

Inhibitors Comment Organism Structure
inositol 1,3,4-trisphosphate 50% inhibition at less than 0.001 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble more than 90% of liver enzyme Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate Rattus norvegicus involved in synthesis of higher phosphorylated inositol phosphates ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate Rattus norvegicus Sprague-Dawley involved in synthesis of higher phosphorylated inositol phosphates ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley strain
-
Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley strain
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
-
 Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate involved in synthesis of higher phosphorylated inositol phosphates Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
-
 Rattus norvegicus Sprague-Dawley ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate involved in synthesis of higher phosphorylated inositol phosphates Rattus norvegicus Sprague-Dawley ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Rattus norvegicus