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Literature summary for 2.7.1.130 extracted from
- Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli (2016), Proc. Natl. Acad. Sci. USA, 113, 3108-3113 .
General Stability
| General Stability | Organism |
|---|---|
| palmitoyl-CoA induces a strong inhibitory effect on FabI. Due to the inhibition of FabI, LpxC would be stabilized | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P27300 | W3110 | - |
| Escherichia coli K12 | P27300 | W3110 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LpxK | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | a model for the biosynthesis of the outer membrane in Escherichia coli is presented. The catalytic activity is dependent on the concentration of unsaturated fatty acids. LpxC is additionally regulated by an unidentified protease whose activity is independent of lipid A disaccharide concentration (the feedback source for FtsH-mediated LpxC regulation) but can be induced in vitro by palmitic acid | Escherichia coli |
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Release 2023.1 (January 2023)
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