Cloned (Comment) | Organism |
---|---|
gene Itpka, quantitative reverse transcription-PCR enzyme expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of IP3K-A KO mice and electrophysiological properties of IP3K-A KO mice, overview. No significant differences in basic electrophysiological properties between groups, such as resting membrane potential and input resistance is found. But the input-output functions of CeL neurons are significantly attenuated along with a longer latency to the first spike in KO mice | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Mus musculus | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Mus musculus C57BL/6N | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8R071 | - |
- |
Mus musculus C57BL/6N | Q8R071 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | IP3K-A expression is highly enriched in the central nucleus of the amygdala (CeA), which plays a pivotal role in the processing and expression of emotional phenotypes in mammals. P3K-A is primarily expressed in neurons rather than glia in the amygdala. In the CeA, IP3K-A primarily colocalizes with GAD67-positive GABAergic interneurons, whereas most IP3K-A in the BLA is in CAMKIIalpha-positive excitatory pyramidal neurons | Mus musculus | - |
brain | - |
Mus musculus | - |
forebrain | - |
Mus musculus | - |
neuron | in the CeA, IP3K-A primarily colocalizes with GAD67-positive GABAergic interneurons, whereas most IP3K-A in the BLA is in CAMKIIalpha-positive excitatory pyramidal neurons | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Mus musculus | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Mus musculus C57BL/6N | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol 1,4,5-trisphosphate 3-kinase A | - |
Mus musculus |
IP3K-A | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | genetic abrogation of IP3K-A alters amygdala gene expression, particularly in genes involved in key intracellular signaling pathways and genes mediating fear- and anxiety-related behaviors. In agreement with the changes in amygdala gene expression profiles, IP3K-A knockout (KO) mice display more robust responses to aversive stimuli and spent less time in the open arms of the elevated plus maze, indicating high levels of innate fear and anxiety. Decreased excitatory and inhibitory postsynaptic current and reduced c-Fos immunoreactivity are found in the CeA of IP3K-A KO mice | Mus musculus |
physiological function | inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is enriched in the brain and neurons that regulates intracellular calcium levels via signaling through the inositol trisphosphate receptor. IP3K-A expression is highly enriched in the central nucleus of the amygdala (CeA), which plays a pivotal role in the processing and expression of emotional phenotypes in mammals. IP3K-A has a profound influence on the basal activities of fear- and anxiety-mediating amygdala circuitry. IP3K-A plays an important role in regulating affective states by modulating metabotropic receptor signaling pathways and neural activity in the amygdala | Mus musculus |