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Literature summary for 2.7.1.127 extracted from

  • Balabin, F.A.; Sveshnikova, A.N.
    Computational biology analysis of platelet signaling reveals roles of feedbacks through phospholipase C and inositol 1,4,5-trisphosphate 3-kinase in controlling amplitude and duration of calcium oscillations (2016), Mathr. Biosci., 276, 67-74 .
    View publication on PubMed
Search for more literature for 2.7.1.127

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol 1,4,5-trisphosphate 3-kinase
-
 Homo sapiens
IP3K
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism main mechanisms of platelet calcium signaling implemented in the model. The model includes two main compartments: cytosol and dense tubular system (DTS). Thrombin binding to PAR1 receptor leads to phospholipase C (PLC) activation and inositol-3-phosphate (IP3) release into cytosol. IP3 binding to its receptors (IP3R) in the DTS membrane opens this channels for release of calcium that is normally contained in the DTS because of the SERCA pump action. Cytosolic IP3 is being phosphorylated by inositol triphosphate-kinase (IP3K) into IP4 that might be included in the phosphoinositide turnover. Two feedback loops: a PLC-dependent positive feedback loop and the IP3K-dependent negative loop. System modeling, overview Homo sapiens
physiological function analysis of the roles of feedbacks through phospholipase C and inositol 1,4,5-trisphosphate 3-kinase (IP3K) by means of a computer model of calcium signal transduction in platelets Homo sapiens