Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | the enzyme is activated by Ca2+/calmodulin. The human isozyme IP3-3K A contains a CaM binding domain at residues 158-183, binding structure and identification all of the key residues involved in the interaction, overview | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystal structure of the complex between human Ca2+/CaM and the CaM-binding region of human IP3-3K isoform A (residues 158-183), modeling of the complex including the kinase domain | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the enzyme is activated by Ca2+/calmodulin | Homo sapiens | |
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23677 | isozyme/gene ITPKA | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ITPKA | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | 1D-myo-inositol 1,4,5-trisphosphate is a key point in Ca2+ metabolism that promotes Ca2+ release from intracellular stores and together with 1D-myo-inositol 1,3,4,5-tetrakisphosphate regulates Ca2+ homoeostasis. In addition, 1D-myo-inositol 1,3,4,5-tetrakisphosphate is involved in immune cell development. Ca2+ and calmodulin regulate the activity of inositol(1,4,5)trisphosphate 3-kinases via direct interaction | Homo sapiens |