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Literature summary for 2.7.1.127 extracted from

  • Scoumanne, A.; Molina-Ortiz, P.; Monteyne, D.; Perez-Morga, D.; Erneux, C.; Schurmans, S.
    Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice (2016), Adv. Biol. Regul., 62, 1-10.
    View publication on PubMed
Search for more literature for 2.7.1.127

Cloned(Commentary)

Cloned (Comment) Organism
gene Itpkc, quantitative real-time PCR expression analysis, recombinant expression in human HEK-293 cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
brush border
-
 Mus musculus 5903
-
flagellum
-
 Mus musculus
-
-
microvillus
-
 Mus musculus 5902
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
 x * 90000, about, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q7TS72 gene Itpkc
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
caecum
-
 Mus musculus
-
ependymal cell
-
 Mus musculus
-
epididymis low expression level Mus musculus
-
epithelium tracheal and bronchial, multiciliated tracheal epithelial cells Mus musculus
-
kidney
-
 Mus musculus
-
large intestine high expression level Mus musculus
-
liver
-
 Mus musculus
-
lung
-
 Mus musculus
-
additional information enzyme tissue expression analysis by immunohistochemic analysis and situ hybridization. Cells positive for ITPKC express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa) Mus musculus
-
proximal tubule
-
 Mus musculus
-
salivary gland
-
 Mus musculus
-
small intestine
-
 Mus musculus
-
sperm cell
-
 Mus musculus
-
spermatozoon epididymal spermatozoa Mus musculus
-
spleen
-
 Mus musculus
-
stomach
-
 Mus musculus
-
testis high expression level Mus musculus
-
thymus
-
 Mus musculus
-
trachea low expression level Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 90000, about, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
inositol 1,4,5-trisphosphate 3-kinase C
-
 Mus musculus
Itpkc
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
evolution a member of the inositol 1,4,5-trisphosphate 3-kinases family Mus musculus
physiological function role for ITPKC either in the development or the function of these specialized cellular structures Mus musculus