Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q9VL83 | isoform IP3K-1 | - |
Drosophila melanogaster | Q9VYE6 | isoforms IP3K-2 | - |
Synonyms | Comment | Organism |
---|---|---|
IP3K1 | - |
Drosophila melanogaster |
IP3K2 | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
physiological function | cell-specific inositol phosphate signalling specifically via inositol 1,4,5-trisphosphate 3-kinase, negatively regulates organismal responses to oxidative stress. The Drosophila malpighian tubule is a key epithelial sensor for organismal oxidative stress responses, precise targeting of either gain-of-function constructs of isoforms IP3K-1 and IP3K-2, or loss-of-function constructs to only one cell type in tubule reversibly modulates survival of stress-challenged adult flies | Drosophila melanogaster |
physiological function | cell-specific inositol phosphate signalling specifically via inositol 1,4,5-trisphosphate 3-kinase, negatively regulates organismal responses to oxidative stress. The Drosophila malpighian tubule is a key epithelial sensor for organismal oxidative stress responses, precise targeting of either gain-of-function constructs of isoforms IP3K-1 and IP3K-2, or loss-of-function constructs to only one cell type in tubule reversibly modulates survival of stress-challenged adult flies. In vivo, targeted isoform IP3K-1 directly increases H2O2 production, pro-apoptotic caspase-9 activity and mitochondrial membrane potential. The mitochondrial calcium load in tubule principal cells is significantly increased by isoform IP3K-1 under oxidative stress conditions, leading to apoptosis | Drosophila melanogaster |