Literature summary for 2.7.1.127 extracted from

Miller, A.T.; Beisner, D.R.; Liu, D.; Cooke, M.P.
Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction (2009), J. Immunol., 182, 4696-4704.

Search for more literature for 2.7.1.127

Cloned(Commentary)

Cloned (Comment)	Organism
inositol 1,4,5-trisphosphate 3-kinase B-deficient mice are crossed to transgenic mice that express a B cell receptor specific for hen egg lysozyme	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	enzyme is Ca-dependent	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate	Mus musculus	enzyme phosphorylates the 3'-position of the inositol ring to convert the substrate to the product	ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate	enzyme phosphorylates the 3'-position of the inositol ring to convert the substrate to the product	Mus musculus	ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate	-	?

Synonyms

Synonyms	Comment	Organism
inositol 1,4,5-trisphosphate 3-kinase B	-	Mus musculus
Itpkb	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	In transgenic mice that also express soluble hen egg lysozyme, lack of inositol 1,4,5-trisphosphate 3-kinase B converts anergy induction to deletion, mice lacking inositol 1,4,5-trisphosphate 3-kinase B have normal B cell development in the bone marrow, but reduced numbers of all splenic B cell subsets and a shift in the developmental fate toward compartments that are normally selected by strong B cell receptor signals, mature B cells lacking the enzyme fail to proliferate in response to B cell receptor stimulation but show normal responses to the TLR4 ligand LPS or agonistic Abs to CD40. At the immature stage, inositol 1,4,5-trisphosphate 3-kinase B-deficient mice possess a 60% increase in the numbers of immature B cells compared with wild type mice. Examination of splenic B cell populations in inositol 1,4,5-trisphosphate 3-kinase B-deficient/IgHEL tg mice reveals that while the total numbers of B220+ cells are relatively normal, the numbers of follicular mature B cells are increased 2.2fold, while the number of T2 and marginal zone cells are reduced 3- and 3.8fold	Mus musculus
physiological function	inositol 1,4,5-trisphosphate 3-kinase B converts inositol 1,4,5-trisphosphate to inositol 1,3,4,5-tetrakisphosphate upon Ag receptor activation and controls the fate and function of lymphocytes	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)