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Literature summary for 2.7.1.127 extracted from

  • Choi, G.; Chang, Y.T.; Chung, S.K.; Choi, K.Y.
    Molecular interactions of all possible regioisomers of synthetic myo-inositol phosphates with inositol 1,4,5-trisphosphate 3-kinase (1997), Bioorg. Med. Chem. Lett., 7, 2709-2714.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
IP3K is overexpressed in Escherichia coli Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
inositol phosphate inhibitory effects of all possible 38 regioisomers of synthetic inositol phosphates, only inositol trisphosphates and tetrakisphosphates inhibit, not or very weak: inositol monophosphates, bisphosphates and pentakisphosphates, the recognition of myo-inositol phosphate regioisomers is highly structure-selective Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus inositol phosphate metabolism ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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recombinant IP3K overexpressed in Escherichia coli
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Purification (Commentary)

Purification (Comment) Organism
recombinant IP3K overexpressed in Escherichia coli Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate environment of the active site, proposed binding site model for Ins(1,4,5)P3 Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?
ATP + 1D-myo-inositol 1,4,5-trisphosphate inositol phosphate metabolism Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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?

Cofactor

Cofactor Comment Organism Structure
ATP ATP-dependent Rattus norvegicus