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Literature summary for 2.7.1.12 extracted from

  • Rohatgi, N.; Nielsen, T.; Bjorn, S.; Axelsson, I.; Paglia, G.; Voldborg, B.; Palsson, B.; Rolfsson, O.
    Biochemical characterization of human gluconokinase and the proposed metabolic impact of gluconic acid as determined by constraint based metabolic network analysis (2014), PLoS ONE, 9, e98760.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.106
-
D-gluconate pH 7.2, temperature not specified in the publication Homo sapiens
0.344
-
ATP pH 7.2, temperature not specified in the publication Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21800
-
-
Homo sapiens
41800
-
PAGE Homo sapiens
85000
-
PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5T6J7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-gluconate
-
Homo sapiens ADP + 6-phospho-D-gluconate
-
?
ATP + D-glucono-1,5-lactone
-
Homo sapiens ADP + 6-phospho-D-glucono-1,5-lactone
-
?
CTP + D-gluconate
-
Homo sapiens CDP + 6-phospho-D-gluconate
-
?
GTP + D-gluconate
-
Homo sapiens GDP + 6-phospho-D-gluconate
-
?
additional information no substrates: D-glucose, D-galactose, D-fructose, D-mannose and D-glucosamine, D-ribose, D-ribulose, D-arabinose, D-xylulose, D-xylose and D-erythrose Homo sapiens ?
-
?
UTP + D-gluconate
-
Homo sapiens UDP + 6-phospho-D-gluconate
-
?

Subunits

Subunits Comment Organism
dimer and tetramer, 2 * 23326, calculated, 2 * 21800, SDS-PAGE Homo sapiens
tetramer and dimer, 4 * 23326, calculated, 4 * 21800, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
C9orf103
-
Homo sapiens
gntK
-
Homo sapiens
IdnK
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
9.3
-
D-gluconate pH 7.2, temperature not specified in the publication Homo sapiens
9.5
-
ATP pH 7.2, temperature not specified in the publication Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
28
-
ATP pH 7.2, temperature not specified in the publication Homo sapiens
89
-
D-gluconate pH 7.2, temperature not specified in the publication Homo sapiens