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Literature summary for 2.7.1.113 extracted from

  • Sun, R.; Eriksson, S.; Wang, L.
    Zidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs (2014), Antimicrob. Agents Chemother., 58, 6758-6766.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + deoxyguanosine Homo sapiens
-
ADP + dGMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U2OS cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + deoxyguanosine
-
Homo sapiens ADP + dGMP
-
?

Synonyms

Synonyms Comment Organism
DGK
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens treatment with 3'-azido-2',3'-dideoxythymidine (zidovudine) treatment leads to downregulation of the mitochondrial enzyme in U2OS cells. Incubation with 1 mM tert-butylhydroperoxide results in 80% and 65% reductions in mitochondrial protein levels. Similarly, incubation with 2 mM diamide leads to about 50% decreases in enzyme expression down