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Literature summary for 2.7.1.113 extracted from

  • Van Rompay, A.R.; Johansson, M.; Karlsson, A.
    Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases (2003), Pharmacol. Ther., 100, 119-139.
    View publication on PubMed
Search for more literature for 2.7.1.113

Application

Application Comment Organism
medicine enzyme is useful in anticancer therapy due to activation of anticancer drugs through phosphorylation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
genetic organization, located on chromosome 2p13, expression as GFP-fusion protein in CHO cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
-
 Homo sapiens 5759
-
mitochondrion N-terminal enzyme sequence contains a mitochondrial import signal Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2'-deoxyadenosine Homo sapiens
-
 ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
ATP + 2'-deoxyguanosine Homo sapiens
-
 ADP + 2'-deoxyguanosine 5'-phosphate
-
 ?
ATP + 2'-deoxyinosine Homo sapiens
-
 ADP + 2'-deoxyinosine 5'-phosphate
-
 ?
additional information Homo sapiens de novo synthesis and salvage of ribonucleotides and deoxyribonucleotides, metabolism overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16854
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lymphoid tissue
-
 Homo sapiens
-
additional information enzyme is expressed in most tissues, enzyme expression throughout the cell cycle Homo sapiens
-
muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxyadenosine
-
 Homo sapiens ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
ATP + 2'-deoxyguanosine
-
 Homo sapiens ADP + 2'-deoxyguanosine 5'-phosphate
-
 ?
ATP + 2'-deoxyinosine
-
 Homo sapiens ADP + 2'-deoxyinosine 5'-phosphate
-
 ?
additional information de novo synthesis and salvage of ribonucleotides and deoxyribonucleotides, metabolism overview Homo sapiens ?
-
 ?
additional information anticancer drugs 2-chloro-2'-deoxyadenosine, i.e. cladribine, and 2-fluoro-9-beta-D-arabinofuranosyladenine, i.e. clofarabine, are poor substrates Homo sapiens ?
-
 ?
UTP + 2'-deoxyadenosine
-
 Homo sapiens UDP + 2'-deoxyadenosine 5'-phosphate
-
 ?
UTP + 2'-deoxyguanosine
-
 Homo sapiens UDP + 2'-deoxyguanosine 5'-phosphate
-
 ?
UTP + 2'-deoxyinosine
-
 Homo sapiens UDP + 2'-deoxyinosine 5'-phosphate
-
 ?
UTP + 9-beta-D-arabinofuranosylguanine i.e. nelarabine, activation of the anticancer drug Homo sapiens UDP + 9-beta-D-arabinofuranosylguanine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
DGK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
additional information enzyme can use several phosphate donors, but UTP is preferred in vitro Homo sapiens
UTP preferred phosphate donor in vitro Homo sapiens