Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Triton X-100 | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene is localized on chromosome 2q13 | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
enzyme in complex with ATP | Homo sapiens |
General Stability | Organism |
---|---|
Triton X-100 and ATP stabilize | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dATP | feedback inhibition | Homo sapiens | |
dGTP | feedback inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial matrix | - |
Homo sapiens | 5759 | - |
mitochondrion | enzyme possesses an N-terminal mitochondrial import signal | Homo sapiens | 5739 | - |
additional information | the enzyme leaks out into the cytosol during cell apoptosis | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
2 * 30000 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxyadenosine | Homo sapiens | - |
ADP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
ATP + 2'-deoxyguanosine | Homo sapiens | - |
ADP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
UTP + 2'-deoxyadenosine | Homo sapiens | - |
UDP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
UTP + 2'-deoxyguanosine | Homo sapiens | - |
UDP + 2'-deoxyguanosine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16854 | constitutive expression | - |
Purification (Comment) | Organism |
---|---|
enzyme activity is stabilized during purification in presence of Triton X-100 and ATP | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + deoxyguanosine = ADP + dGMP | substrate interactions, reaction mechanism | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lymphoid tissue | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-beta-D-arabinofuranosyladenine | - |
Homo sapiens | ADP + 1-beta-D-arabinofuranosyladenine 5'-phosphate | - |
? | |
ATP + 2',2'-difluorodeoxyguanosine | - |
Homo sapiens | ADP + 2',2'-difluorodeoxyguanosine 5'-phosphate | - |
? | |
ATP + 2'-deoxyadenosine | - |
Homo sapiens | ADP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
ATP + 2'-deoxyguanosine | - |
Homo sapiens | ADP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
ATP + 2'-deoxyinosine | - |
Homo sapiens | ADP + 2'-deoxyinosine 5'-phosphate | - |
? | |
ATP + 2-chloro-2'-arabinofluoro-2'-deoxyadenosine | - |
Homo sapiens | ADP + 2-chloro-2'-arabinofluoro-2'-deoxyadenosine 5'-phosphate | - |
? | |
ATP + 2-chlorodeoxyadenosine | - |
Homo sapiens | ADP + 2-chlorodeoxyadenosine 5'-phosphate | - |
? | |
ATP + 9-beta-D-arabinofuranosylguanine | - |
Homo sapiens | ADP + 9-beta-D-arabinofuranosylguanine 5'-phosphate | - |
? | |
ATP + ganciclovir | i.e. 9-(1,3-dihydroxy-2-propoxymethyl)-guanine, low activity | Homo sapiens | ADP + ganciclovir phosphate | - |
? | |
ATP + penciclovir | i.e. 9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-guanine, low activity | Homo sapiens | ADP + penciclovir 5'-phosphate | - |
? | |
additional information | substrate interactions, overview, enzyme shows relaxed enantioselectivity, accepting D- and L-enantiomers of beta-deoxyguanosine but with lower activity than alpha-L-deoxyguanosine, and beta-L-deoxyadenosine, enzyme accepts purine deoxynucleosides and analogues as substrates utilizing a triphosphate donor substrate | Homo sapiens | ? | - |
? | |
UTP + 2'-deoxyadenosine | - |
Homo sapiens | UDP + 2'-deoxyadenosine 5'-phosphate | - |
? | |
UTP + 2'-deoxyguanosine | - |
Homo sapiens | UDP + 2'-deoxyguanosine 5'-phosphate | - |
? | |
UTP + 2'-deoxyinosine | - |
Homo sapiens | UDP + 2'-deoxyinosine 5'-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 30000 | Homo sapiens |
More | ternary and quarternary structure analysis, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DGK | - |
Homo sapiens |
nucleoside triphosphate: deoxyguanosine 5'-phosphotransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | binding site structure and interactions, Gln111, Arg118, Met99, and Asp147 are involved, overview | Homo sapiens | |
additional information | enzyme accepts several triphosphate donor substrates with preference for ATP and UTP | Homo sapiens | |
UTP | - |
Homo sapiens |