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Literature summary for 2.7.1.113 extracted from

  • Park, I.; Ives, D.H.
    Mutations within the putative active site of heterodimeric deoxyguanosine kinase block the allosteric activation of the deoxyadenosine kinase subunit (2002), J. Biochem. Mol. Biol., 35, 244-247.
    View publication on PubMed
Search for more literature for 2.7.1.113

Protein Variants

Protein Variants Comment Organism
D84A 1% of wild-type activity Lactobacillus johnsonii
D84E 41% of wild-type activity, not inhibited by dGTP and dATP Lactobacillus johnsonii
D84N 5% of wild-type activity Lactobacillus johnsonii

Inhibitors

Inhibitors Comment Organism Structure
dGTP
-
 Lactobacillus johnsonii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.087
-
 deoxyguanosine pH 8.0, 20°C Lactobacillus johnsonii
0.34
-
 deoxyguanosine pH 8.0, 20°C, D84N mutant enzyme Lactobacillus johnsonii
0.36
-
 deoxyguanosine pH 8.0, 20°C, D84A mutant enzyme Lactobacillus johnsonii
0.55
-
 deoxyguanosine pH 8.0, 20°C, D84E mutant enzyme Lactobacillus johnsonii

Organism

Organism UniProt Comment Textmining
Lactobacillus johnsonii Q74HC2 strain R-26, heterodimeric enzyme, deoxyadenosine kinase/deoxguanosine kinase
-
Lactobacillus johnsonii NCC 533 Q74HC2 strain R-26, heterodimeric enzyme, deoxyadenosine kinase/deoxguanosine kinase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + deoxyguanosine
-
 Lactobacillus johnsonii ADP + dGMP
-
 ?
ATP + deoxyguanosine
-
 Lactobacillus johnsonii NCC 533 ADP + dGMP
-
 ?

Synonyms

Synonyms Comment Organism
deoxyadenosine kinase/deoxyguanosine kinase abbrevation: dAK/dGK Lactobacillus johnsonii