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Literature summary for 2.7.1.113 extracted from
- Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol (1979), J. Biol. Chem., 254, 2180-2183.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dCDP | slight stimulation, with ATP as substrate | Bos taurus |  |
| dTDP | 1 mM, 620% activation of mitochondrial deoxyguanosine kinase, positive modulation with ATP as substrate | Bos taurus | |
| dTTP | 1 mM, 280% activation of mitochondrial deoxyguanosine kinase | Bos taurus | |
| additional information | not activated by dCTP or dATP, with ATP as substrate | Bos taurus | |
| Sodium diphosphate | 1 mM, 120% stimulation of mitochondrial deoxyguanosine kinase | Bos taurus | |
| UDP | 1 mM, 310% activation of mitochondrial deoxyguanosine kinase, with ATP as substrate | Bos taurus | |
| UTP | 1 mM, 190% activation of mitochondrial deoxyguanosine kinase | Bos taurus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dGDP | 0.1 mM, 55% inhibition | Bos taurus | |
| dGMP | very weak inhibition | Bos taurus | |
| dGTP | 1 mM, 96% inhibition | Bos taurus | |
| dITP | 0.1 mM, 65% inhibition | Bos taurus | |
| additional information | not inhibited by dADP; not inhibited by dATP; not inhibited by dCTP; not inhibited by GTP | Bos taurus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.006 | - |
deoxyguanosine | pH 7.5, 37°C, mitochondrial deoxyguanosine kinase | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Bos taurus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for activity | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + deoxyguanosine | Bos taurus | enzyme of purine deoxynucleoside salvage pathway | ADP + dGMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| mitochondrial deoxyguanosine kinase, Sephacryl S-200, Blue Sepharose CL6B | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thymus | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + deoxyguanosine | no activity with deoxycytidine | Bos taurus | ADP + dGMP | - |
? | |
| ATP + deoxyguanosine | no activity with inosine and 9-beta-arabinofuranosyladenine | Bos taurus | ADP + dGMP | - |
? | |
| ATP + deoxyguanosine | no activity with deoxythymidine, uridine and cytosine | Bos taurus | ADP + dGMP | - |
? | |
| ATP + deoxyguanosine | no activity with adenosine | Bos taurus | ADP + dGMP | - |
? | |
| ATP + deoxyguanosine | enzyme of purine deoxynucleoside salvage pathway | Bos taurus | ADP + dGMP | - |
? | |
| ATP + deoxyinosine | - |
Bos taurus | ADP + dIMP | - |
? | |
| ATP + guanosine | mitochondrial deoxyguanosine kinase | Bos taurus | ADP + GMP | - |
? | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Bos taurus | mitochondrial deoxyguanosine kinase, isoelectric focusing | - |
5.9 |
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