Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dCDP | slight stimulation, with ATP as substrate | Bos taurus | |
dTDP | 1 mM, 620% activation of mitochondrial deoxyguanosine kinase, positive modulation with ATP as substrate | Bos taurus | |
dTTP | 1 mM, 280% activation of mitochondrial deoxyguanosine kinase | Bos taurus | |
additional information | not activated by dCTP or dATP, with ATP as substrate | Bos taurus | |
Sodium diphosphate | 1 mM, 120% stimulation of mitochondrial deoxyguanosine kinase | Bos taurus | |
UDP | 1 mM, 310% activation of mitochondrial deoxyguanosine kinase, with ATP as substrate | Bos taurus | |
UTP | 1 mM, 190% activation of mitochondrial deoxyguanosine kinase | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dGDP | 0.1 mM, 55% inhibition | Bos taurus | |
dGMP | very weak inhibition | Bos taurus | |
dGTP | 1 mM, 96% inhibition | Bos taurus | |
dITP | 0.1 mM, 65% inhibition | Bos taurus | |
additional information | not inhibited by dADP; not inhibited by dATP; not inhibited by dCTP; not inhibited by GTP | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.006 | - |
deoxyguanosine | pH 7.5, 37°C, mitochondrial deoxyguanosine kinase | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Bos taurus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for activity | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxyguanosine | Bos taurus | enzyme of purine deoxynucleoside salvage pathway | ADP + dGMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
calf | - |
Purification (Comment) | Organism |
---|---|
mitochondrial deoxyguanosine kinase, Sephacryl S-200, Blue Sepharose CL6B | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thymus | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + deoxyguanosine | no activity with deoxycytidine | Bos taurus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | no activity with inosine and 9-beta-arabinofuranosyladenine | Bos taurus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | no activity with deoxythymidine, uridine and cytosine | Bos taurus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | no activity with adenosine | Bos taurus | ADP + dGMP | - |
? | |
ATP + deoxyguanosine | enzyme of purine deoxynucleoside salvage pathway | Bos taurus | ADP + dGMP | - |
? | |
ATP + deoxyinosine | - |
Bos taurus | ADP + dIMP | - |
? | |
ATP + guanosine | mitochondrial deoxyguanosine kinase | Bos taurus | ADP + GMP | - |
? |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Bos taurus | mitochondrial deoxyguanosine kinase, isoelectric focusing | - |
5.9 |