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Literature summary for 2.7.1.11 extracted from

  • Zhang, F.; Qian, X.; Qin, C.; Lin, Y.; Wu, H.; Chang, L.; Luo, C.; Zhu, D.
    Phosphofructokinase-1 negatively regulates neurogenesis from neural stem cells (2016), Neurosci. Bull., 32, 205-216 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-fructose 6-phosphate Mus musculus phosphofructokinase-1 is an important control point in the glycolytic pathway, it is implicated in the functions of astrocytes and neurons ADP + D-fructose 1,6-bisphosphate
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
neural stem cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose 6-phosphate
-
 Mus musculus ADP + D-fructose 1,6-bisphosphate
-
 ?
ATP + D-fructose 6-phosphate phosphofructokinase-1 is an important control point in the glycolytic pathway, it is implicated in the functions of astrocytes and neurons Mus musculus ADP + D-fructose 1,6-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PFK-1
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 Mus musculus
phosphofructokinase-1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction knockdown of phosphofructokinase-1 promotes neurogenesis by enhancing the proliferation of neural progenitors and instructing these progenitors to adopt a neuronal fate, and this effect is achieved by the upregulation of Mash 1, NeuroD, and Sox2 Mus musculus
physiological function phosphofructokinase-1 is an important regulator of neurogenesis Mus musculus