Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q01813 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | phosphofructokinase-P is overexpressed in diverse types of cancer including HeLa cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PFK-P | - |
Homo sapiens |
phosphofructokinase-P | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | phosphofructokinase-P is overexpressed in diverse types of cancer including HeLa cells | up |
General Information | Comment | Organism |
---|---|---|
drug target | overexpression of phosphofructokinase-P by cancer cells is related to activation of survival pathways via upregulation ofMAPK and suggest PFK-P as a promising target for cancer therapy | Homo sapiens |
malfunction | silencing of phosphofructokinase-P does not alter HeLa cell viability or energy production, including the glycolytic rate. Silencing of PFK-P induces the downregulation of p44/42 MAPK, augmenting the sensitivity of HeLa cells to different drugs | Homo sapiens |
physiological function | phosphofructokinase-P modulates expression of P44/42 mitogen-activated protein kinase. Overexpression of phosphofructokinase-P promotes the upregulation of p44/42 MAPK, making the cells more resistant to the drugs | Homo sapiens |