Literature summary for 2.7.1.11 extracted from

Cardim Pires, T.R.; Albanese, J.M.; Schwab, M.; Marette, A.; Carvalho, R.S.; Sola-Penna, M.; Zancan, P.
Phosphofructokinase-P modulates P44/42 MAPK levels in HeLa Cells (2017), J. Cell. Biochem., 118, 1216-1226 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q01813	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	phosphofructokinase-P is overexpressed in diverse types of cancer including HeLa cells	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PFK-P	-	Homo sapiens
phosphofructokinase-P	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	phosphofructokinase-P is overexpressed in diverse types of cancer including HeLa cells	up

General Information

General Information	Comment	Organism
drug target	overexpression of phosphofructokinase-P by cancer cells is related to activation of survival pathways via upregulation ofMAPK and suggest PFK-P as a promising target for cancer therapy	Homo sapiens
malfunction	silencing of phosphofructokinase-P does not alter HeLa cell viability or energy production, including the glycolytic rate. Silencing of PFK-P induces the downregulation of p44/42 MAPK, augmenting the sensitivity of HeLa cells to different drugs	Homo sapiens
physiological function	phosphofructokinase-P modulates expression of P44/42 mitogen-activated protein kinase. Overexpression of phosphofructokinase-P promotes the upregulation of p44/42 MAPK, making the cells more resistant to the drugs	Homo sapiens

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Release 2023.1 (January 2023)