Any feedback?
Literature summary for 2.7.1.11 extracted from
- Regulation of canine skeletal muscle phosphofructokinase-1 by adenine nucleotides (2019), Int. J. Appl. Res. Vet. Med., 17, 10-16 .
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ADP | activates at low concentrations, but slightly inhibits at higher concentrations | Canis lupus familiaris |  |
| AMP | activating effector | Canis lupus familiaris | |
| cAMP | activating effector | Canis lupus familiaris | |
| D-fructose 2,6-bisphosphate | activates | Canis lupus familiaris | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | nearly complete inhibition at 5 mM ATP | Canis lupus familiaris | |
| citrate | - |
Canis lupus familiaris | |
| UTP | does not inhibit activity to the same extent as ATP | Canis lupus familiaris | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-fructose 6-phosphate | Canis lupus familiaris | - |
ADP + D-fructose 1,6-bisphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | P52784 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Canis lupus familiaris |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skeletal muscle | - |
Canis lupus familiaris | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4.6 | - |
25°C, pH 8.2 | Canis lupus familiaris |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-fructose 6-phosphate | - |
Canis lupus familiaris | ADP + D-fructose 1,6-bisphosphate | - |
? | |
| UTP + D-fructose 6-phosphate | - |
Canis lupus familiaris | UDP + D-fructose 1,6-bisphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PFK-1 | - |
Canis lupus familiaris |
| phosphofructokinase-1 | - |
Canis lupus familiaris |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.2 | - |
- |
Canis lupus familiaris |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | 8.8 | pH 7.6: about 60% of maximal activity, pH 8.8: about 75% of maximal activity | Canis lupus familiaris |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
