Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Mus musculus | - |
muscle | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-fructose 6-phosphate | - |
Mus musculus | ADP + D-fructose 1,6-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PFK-1 | - |
Mus musculus |
PFKM | - |
Mus musculus |
phosphofructo-1-kinase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | phosphofructo-1-kinase deficiency leads to a severe cardiac and hematological disorder in addition to skeletal muscle glycogenosis, the lack of PFK activity blocks glycolysis and results in considerable glycogen storage and low ATP content, although erythrocytes of PFK knockout mice preserve 50% of PFK activity, they show strong reduction of 2,3-biphosphoglycerate concentrations and hemolysis, PFK knockout mice exhibit high lethality and skeletal muscle glycogenosis | Mus musculus |