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Literature summary for 2.7.1.11 extracted from
- Purification and kinetic properties of 6-phosphofructo-1-kinase from gilthead sea bream muscle (2007), Biochim. Biophys. Acta, 1770, 706-715.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ADP | activates | Sparus aurata |  |
| AMP | activates | Sparus aurata | |
| D-fructose-1,6-bisphosphate | activates synergistically with AMP and ADP | Sparus aurata | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-phosphoglycerate | mixed inhibition | Sparus aurata | |
| ATP | potentiates inhibitory action of citrate | Sparus aurata | |
| citrate | - |
Sparus aurata | |
| phosphoenolpyruvate | mixed inhibition | Sparus aurata | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 81000 | - |
8 * 81000, SDS-PAGE | Sparus aurata |
| 662000 | - |
gel filtration | Sparus aurata |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sparus aurata | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation of PFKM may exert a major role during starvation in fish muscle | Sparus aurata |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sparus aurata |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skeletal muscle | - |
Sparus aurata | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2077 | - |
- |
Sparus aurata |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| octamer | 8 * 81000, SDS-PAGE | Sparus aurata |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-phosphofructo-1-kinase | - |
Sparus aurata |
| PFKM | - |
Sparus aurata |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.25 | - |
Sparus aurata |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0207 | - |
3-phosphoglycerate | Ki(slope) | Sparus aurata | |
| 0.0272 | - |
phosphoenolpyruvate | Ki(slope) | Sparus aurata | |
| 0.0679 | - |
3-phosphoglycerate | Ki(intercept) | Sparus aurata | |
| 0.187 | - |
phosphoenolpyruvate | Ki(intercept) | Sparus aurata | |
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