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Literature summary for 2.7.1.11 extracted from

  • Bloxham, D.P.; Lardy, H.A.
    Phosphofructokinase (1973), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 8, 239-278.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
ADP
-
Rattus norvegicus
ADP
-
Saccharomyces cerevisiae
ADP
-
Clostridium pasteurianum
ADP
-
Fasciola hepatica
AMP
-
Rattus norvegicus
AMP
-
Saccharomyces cerevisiae
AMP
-
Bos taurus
AMP
-
Fasciola hepatica
cAMP
-
Rattus norvegicus
cAMP
-
Oryctolagus cuniculus
cAMP
-
Fasciola hepatica
glutathione activation Oryctolagus cuniculus
NH4+
-
Escherichia coli
NH4+
-
Saccharomyces cerevisiae
NH4+
-
Oryctolagus cuniculus
NH4+
-
Clostridium pasteurianum
NH4+
-
Fasciola hepatica
NH4+ activation of muscle enzyme, inhibitory at high concentrations Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Gallus gallus
-
Saccharomyces cerevisiae
-
Oryctolagus cuniculus
-
Ovis aries
-
Clostridium pasteurianum

General Stability

General Stability Organism
dilution reversibly decreases activity Oryctolagus cuniculus
dilution reversibly decreases activity Glutamicibacter nicotianae

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate brain PFK, not heart PFK Rattus norvegicus
ADP
-
Clostridium pasteurianum
ADP plant enzymes Pisum sativum
ADP plant enzymes Zea mays
AMP
-
Brassica oleracea var. gemmifera
AMP weak inhibition Daucus carota
AMP weak inhibition Lactiplantibacillus plantarum
AMP weak inhibition Neurospora crassa
AMP weak inhibition Pisum sativum
AMP
-
Zea mays
Antibodies against rabbit muscle enzyme not rabbit erythrocyte, leukocyte or platelet enzyme Oryctolagus cuniculus
ATP
-
Bos taurus
ATP
-
Escherichia coli
ATP
-
Fasciola hepatica
ATP
-
Homo sapiens
ATP ADP partially reverses inhibition Klebsiella aerogenes
ATP ADP partially reverses inhibition; cAMP partially reverses inhibition; fructose 1,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition Mus musculus
ATP muscle PFK, strong inhibition at pH 7.1, weak inhibition at pH 7.6-8.5, not inhibited at pH 9.0 Oryctolagus cuniculus
ATP
-
Ovis aries
ATP fructose 1,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition Rattus norvegicus
ATP
-
Saccharomyces cerevisiae
cAMP
-
Lactiplantibacillus plantarum
cis-aconitate brain, not heart Rattus norvegicus
citrate strong inhibition Arthrobacter crystallopoietes
citrate strong inhibition Bos taurus
citrate strong inhibition Brassica oleracea var. gemmifera
citrate strong inhibition Clostridium pasteurianum
citrate strong inhibition Daucus carota
citrate strong inhibition Dictyostelium discoideum
citrate strong inhibition Escherichia coli
citrate strong inhibition Fasciola hepatica
citrate strong inhibition Gallus gallus
citrate strong inhibition Glutamicibacter nicotianae
citrate strong inhibition Homo sapiens
citrate strong inhibition Klebsiella aerogenes
citrate strong inhibition Lacticaseibacillus casei
citrate strong inhibition Lactiplantibacillus plantarum
citrate strong inhibition Mus musculus
citrate strong inhibition Neurospora crassa
citrate strong inhibition Oryctolagus cuniculus
citrate strong inhibition Ovis aries
citrate strong inhibition Pisum sativum
citrate strong inhibition; synergistic with phosphate and AMP Rattus norvegicus
citrate strong inhibition Saccharomyces cerevisiae
citrate strong inhibition Thermus thermophilus
citrate strong inhibition Zea mays
D-fructose 1,6-bisphosphate
-
Clostridium pasteurianum
D-fructose 1,6-bisphosphate
-
Dictyostelium discoideum
D-Fructose 1-phosphate
-
Arthrobacter crystallopoietes
D-Fructose 1-phosphate
-
Bos taurus
D-Fructose 1-phosphate
-
Brassica oleracea var. gemmifera
D-Fructose 1-phosphate
-
Clostridium pasteurianum
D-Fructose 1-phosphate
-
Daucus carota
D-Fructose 1-phosphate
-
Dictyostelium discoideum
D-Fructose 1-phosphate
-
Escherichia coli
D-Fructose 1-phosphate
-
Fasciola hepatica
D-Fructose 1-phosphate
-
Gallus gallus
D-Fructose 1-phosphate
-
Glutamicibacter nicotianae
D-Fructose 1-phosphate
-
Homo sapiens
D-Fructose 1-phosphate
-
Klebsiella aerogenes
D-Fructose 1-phosphate
-
Lacticaseibacillus casei
D-Fructose 1-phosphate
-
Lactiplantibacillus plantarum
D-Fructose 1-phosphate
-
Mus musculus
D-Fructose 1-phosphate
-
Neurospora crassa
D-Fructose 1-phosphate
-
Oryctolagus cuniculus
D-Fructose 1-phosphate
-
Ovis aries
D-Fructose 1-phosphate
-
Pisum sativum
D-Fructose 1-phosphate
-
Rattus norvegicus
D-Fructose 1-phosphate
-
Saccharomyces cerevisiae
D-Fructose 1-phosphate
-
Thermus thermophilus
D-Fructose 1-phosphate
-
Zea mays
isocitrate brain, not heart Rattus norvegicus
malate kidney cortex, brain, not heart Rattus norvegicus
Maleic anhydride muscle and heart enzymes, mechanism Mus musculus
Maleic anhydride muscle and heart enzymes, mechanism Oryctolagus cuniculus
Maleic anhydride muscle and heart enzymes, mechanism Rattus norvegicus
Mg2+ brain enzyme, at high concentrations Mus musculus
Mg2+ brain enzyme, at high concentrations Oryctolagus cuniculus
Mg2+ brain enzyme, at high concentrations Rattus norvegicus
additional information not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate Arthrobacter crystallopoietes
additional information not inhibited by fructose 1,6-bisphosphate Bos taurus
additional information not inhibited by fructose 1,6-bisphosphate Brassica oleracea var. gemmifera
additional information not inhibited by fructose 1,6-bisphosphate Clostridium pasteurianum
additional information not inhibited by fructose 1,6-bisphosphate Daucus carota
additional information not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate Dictyostelium discoideum
additional information not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA Escherichia coli
additional information not inhibited by fructose 1,6-bisphosphate Fasciola hepatica
additional information not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA Gallus gallus
additional information not inhibited by fructose 1,6-bisphosphate Glutamicibacter nicotianae
additional information not inhibited by fructose 1,6-bisphosphate Homo sapiens
additional information not inhibited by fructose 1,6-bisphosphate Klebsiella aerogenes
additional information not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate Lacticaseibacillus casei
additional information not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate Lactiplantibacillus plantarum
additional information not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP Mus musculus
additional information not inhibited by fructose 1,6-bisphosphate Neurospora crassa
additional information not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP Oryctolagus cuniculus
additional information not inhibited by fructose 1,6-bisphosphate Ovis aries
additional information not inhibited by fructose 1,6-bisphosphate Pisum sativum
additional information heart enzyme, not inhibited by cis-aconitate, L-isocitrate, alpha-ketoglutarate, succinate, fumarate, malate, tricarnallylic acid, CoASH, or acetyl-CoASH; not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP Rattus norvegicus
additional information not inhibited by fructose 1,6-bisphosphate; not inhibited by GTP; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA Saccharomyces cerevisiae
additional information not inhibited by fructose 1,6-bisphosphate Thermus thermophilus
additional information not inhibited by fructose 1,6-bisphosphate Zea mays
NH4+ muscle PFK, weak, at high concentrations, activation at very low concentrations Oryctolagus cuniculus
phosphoenolpyruvate
-
Escherichia coli
phosphoenolpyruvate
-
Mus musculus
phosphoenolpyruvate
-
Rattus norvegicus
pyridoxal 5'-phosphate muscle and heart enzymes, mechanism Mus musculus
pyridoxal 5'-phosphate muscle and heart enzymes, mechanism Oryctolagus cuniculus
pyridoxal 5'-phosphate muscle and heart enzymes, mechanism Rattus norvegicus
succinate kidney cortex and brain PFK, heart PFk is not inhibited Rattus norvegicus
Succinic anhydride muscle and heart enzymes, mechanism Mus musculus
Succinic anhydride muscle and heart enzymes, mechanism Oryctolagus cuniculus
Succinic anhydride muscle and heart enzymes, mechanism Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic data of various organism Gallus gallus
additional information
-
additional information kinetic data of various organism Lactiplantibacillus plantarum
additional information
-
additional information kinetic data of various organism Mus musculus
additional information
-
additional information kinetic data of various organism Thermus thermophilus
additional information
-
additional information kinetic data of various organism Escherichia coli
additional information
-
additional information kinetic data of various organism Homo sapiens
additional information
-
additional information kinetic data of various organism Rattus norvegicus
additional information
-
additional information kinetic data of various organism Saccharomyces cerevisiae
additional information
-
additional information kinetic data of various organism Bos taurus
additional information
-
additional information kinetic data of various organism Oryctolagus cuniculus
additional information
-
additional information kinetic data of various organism Neurospora crassa
additional information
-
additional information kinetic data of various organism Ovis aries
additional information
-
additional information kinetic data of various organism Pisum sativum
additional information
-
additional information kinetic data of various organism Zea mays
additional information
-
additional information kinetic data of various organism Klebsiella aerogenes
additional information
-
additional information kinetic data of various organism Dictyostelium discoideum
additional information
-
additional information kinetic data of various organism Lacticaseibacillus casei
additional information
-
additional information kinetic data of various organism Clostridium pasteurianum
additional information
-
additional information kinetic data of various organism Daucus carota
additional information
-
additional information kinetic data of various organism Glutamicibacter nicotianae
additional information
-
additional information kinetic data of various organism Fasciola hepatica
additional information
-
additional information kinetic data of various organism Arthrobacter crystallopoietes
additional information
-
additional information kinetic data of various organism Brassica oleracea var. gemmifera

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Gallus gallus 5829
-
cytosol
-
Lactiplantibacillus plantarum 5829
-
cytosol
-
Mus musculus 5829
-
cytosol
-
Thermus thermophilus 5829
-
cytosol
-
Escherichia coli 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-
cytosol
-
Saccharomyces cerevisiae 5829
-
cytosol
-
Bos taurus 5829
-
cytosol
-
Oryctolagus cuniculus 5829
-
cytosol
-
Neurospora crassa 5829
-
cytosol
-
Ovis aries 5829
-
cytosol
-
Pisum sativum 5829
-
cytosol
-
Zea mays 5829
-
cytosol
-
Klebsiella aerogenes 5829
-
cytosol
-
Dictyostelium discoideum 5829
-
cytosol
-
Lacticaseibacillus casei 5829
-
cytosol
-
Clostridium pasteurianum 5829
-
cytosol
-
Daucus carota 5829
-
cytosol
-
Glutamicibacter nicotianae 5829
-
cytosol
-
Fasciola hepatica 5829
-
cytosol
-
Arthrobacter crystallopoietes 5829
-
cytosol
-
Brassica oleracea var. gemmifera 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+
-
Gallus gallus
Co2+
-
Lactiplantibacillus plantarum
Co2+
-
Mus musculus
Co2+
-
Thermus thermophilus
Co2+
-
Escherichia coli
Co2+
-
Homo sapiens
Co2+
-
Rattus norvegicus
Co2+
-
Saccharomyces cerevisiae
Co2+
-
Bos taurus
Co2+
-
Oryctolagus cuniculus
Co2+
-
Neurospora crassa
Co2+
-
Ovis aries
Co2+
-
Pisum sativum
Co2+
-
Zea mays
Co2+
-
Klebsiella aerogenes
Co2+
-
Dictyostelium discoideum
Co2+
-
Lacticaseibacillus casei
Co2+
-
Clostridium pasteurianum
Co2+
-
Daucus carota
Co2+
-
Glutamicibacter nicotianae
Co2+
-
Fasciola hepatica
Co2+
-
Arthrobacter crystallopoietes
Co2+
-
Brassica oleracea var. gemmifera
K+
-
Lactiplantibacillus plantarum
K+
-
Mus musculus
K+
-
Thermus thermophilus
K+
-
Escherichia coli
K+
-
Rattus norvegicus
K+
-
Saccharomyces cerevisiae
K+
-
Neurospora crassa
K+
-
Pisum sativum
K+
-
Zea mays
K+
-
Klebsiella aerogenes
K+
-
Dictyostelium discoideum
K+
-
Lacticaseibacillus casei
K+
-
Clostridium pasteurianum
K+
-
Daucus carota
K+
-
Glutamicibacter nicotianae
K+
-
Fasciola hepatica
K+
-
Arthrobacter crystallopoietes
K+
-
Brassica oleracea var. gemmifera
Mg2+ required for activity Gallus gallus
Mg2+ required for activity Lactiplantibacillus plantarum
Mg2+ required for activity Mus musculus
Mg2+ required for activity Thermus thermophilus
Mg2+ required for activity Escherichia coli
Mg2+ required for activity Homo sapiens
Mg2+ required for activity Rattus norvegicus
Mg2+ required for activity Saccharomyces cerevisiae
Mg2+ required for activity Bos taurus
Mg2+ required for activity Oryctolagus cuniculus
Mg2+ required for activity Neurospora crassa
Mg2+ required for activity Ovis aries
Mg2+ required for activity Pisum sativum
Mg2+ required for activity Zea mays
Mg2+ required for activity Klebsiella aerogenes
Mg2+ required for activity Dictyostelium discoideum
Mg2+ required for activity Lacticaseibacillus casei
Mg2+ required for activity Clostridium pasteurianum
Mg2+ required for activity Daucus carota
Mg2+ required for activity Glutamicibacter nicotianae
Mg2+ required for activity Fasciola hepatica
Mg2+ required for activity Arthrobacter crystallopoietes
Mg2+ required for activity Brassica oleracea var. gemmifera
Mg2+ MgATP is the active substrate Gallus gallus
Mg2+ MgATP is the active substrate Lactiplantibacillus plantarum
Mg2+ MgATP is the active substrate Mus musculus
Mg2+ MgATP is the active substrate Thermus thermophilus
Mg2+ MgATP is the active substrate Escherichia coli
Mg2+ MgATP is the active substrate Homo sapiens
Mg2+ MgATP is the active substrate Rattus norvegicus
Mg2+ MgATP is the active substrate Saccharomyces cerevisiae
Mg2+ MgATP is the active substrate Bos taurus
Mg2+ MgATP is the active substrate Oryctolagus cuniculus
Mg2+ MgATP is the active substrate Neurospora crassa
Mg2+ MgATP is the active substrate Ovis aries
Mg2+ MgATP is the active substrate Pisum sativum
Mg2+ MgATP is the active substrate Zea mays
Mg2+ MgATP is the active substrate Klebsiella aerogenes
Mg2+ MgATP is the active substrate Dictyostelium discoideum
Mg2+ MgATP is the active substrate Lacticaseibacillus casei
Mg2+ MgATP is the active substrate Clostridium pasteurianum
Mg2+ MgATP is the active substrate Daucus carota
Mg2+ MgATP is the active substrate Glutamicibacter nicotianae
Mg2+ MgATP is the active substrate Fasciola hepatica
Mg2+ MgATP is the active substrate Arthrobacter crystallopoietes
Mg2+ MgATP is the active substrate Brassica oleracea var. gemmifera
Mg2+ most effective ion Gallus gallus
Mg2+ most effective ion Lactiplantibacillus plantarum
Mg2+ most effective ion Mus musculus
Mg2+ most effective ion Thermus thermophilus
Mg2+ most effective ion Escherichia coli
Mg2+ most effective ion Homo sapiens
Mg2+ most effective ion Rattus norvegicus
Mg2+ most effective ion Saccharomyces cerevisiae
Mg2+ most effective ion Bos taurus
Mg2+ most effective ion Oryctolagus cuniculus
Mg2+ most effective ion Neurospora crassa
Mg2+ most effective ion Ovis aries
Mg2+ most effective ion Pisum sativum
Mg2+ most effective ion Zea mays
Mg2+ most effective ion Klebsiella aerogenes
Mg2+ most effective ion Dictyostelium discoideum
Mg2+ most effective ion Lacticaseibacillus casei
Mg2+ most effective ion Clostridium pasteurianum
Mg2+ most effective ion Daucus carota
Mg2+ most effective ion Glutamicibacter nicotianae
Mg2+ most effective ion Fasciola hepatica
Mg2+ most effective ion Arthrobacter crystallopoietes
Mg2+ most effective ion Brassica oleracea var. gemmifera
Mn2+ activation Gallus gallus
Mn2+ activation Lactiplantibacillus plantarum
Mn2+ activation Mus musculus
Mn2+ activation Thermus thermophilus
Mn2+ activation Escherichia coli
Mn2+ activation Homo sapiens
Mn2+ activation Rattus norvegicus
Mn2+ activation Saccharomyces cerevisiae
Mn2+ activation Bos taurus
Mn2+ activation Oryctolagus cuniculus
Mn2+ activation Neurospora crassa
Mn2+ activation Ovis aries
Mn2+ activation Pisum sativum
Mn2+ activation Zea mays
Mn2+ activation Klebsiella aerogenes
Mn2+ activation Dictyostelium discoideum
Mn2+ activation Lacticaseibacillus casei
Mn2+ activation Clostridium pasteurianum
Mn2+ activation Daucus carota
Mn2+ activation Glutamicibacter nicotianae
Mn2+ activation Fasciola hepatica
Mn2+ activation Arthrobacter crystallopoietes
Mn2+ activation Brassica oleracea var. gemmifera

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
4 * 35000, isoenzyme PFK1, tetrahedral arranged subunits, SDS-PAGE Escherichia coli
36500
-
x * 36500, sedimentation equilibrium centrifugation in 6 M guanidine Escherichia coli
67000
-
6 * 67000, muscle enzyme, sedimentation equilibrium ultracentrifugation or gel filtration in 6.5 M guanidine Oryctolagus cuniculus
141000 142000
-
Escherichia coli
144000
-
-
Clostridium pasteurianum
300000
-
gel filtration Mus musculus
380000
-
-
Rattus norvegicus
380000
-
skeletal muscle Oryctolagus cuniculus
500000
-
erythrocyte, sucrose density gradient centrifugation Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-fructose 6-phosphate Gallus gallus
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Lactiplantibacillus plantarum
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Mus musculus
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Thermus thermophilus
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Escherichia coli
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Homo sapiens
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Rattus norvegicus
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Saccharomyces cerevisiae
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Bos taurus
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Oryctolagus cuniculus
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Neurospora crassa
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Ovis aries
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Pisum sativum
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Zea mays
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Klebsiella aerogenes
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Dictyostelium discoideum
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Lacticaseibacillus casei
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Clostridium pasteurianum
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Daucus carota
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Glutamicibacter nicotianae
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Fasciola hepatica
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Arthrobacter crystallopoietes
-
ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate Brassica oleracea var. gemmifera
-
ADP + D-fructose 1,6-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Arthrobacter crystallopoietes
-
-
-
Bos taurus
-
ox
-
Bos taurus
-
calf
-
Brassica oleracea var. gemmifera
-
Brussel's sprout
-
Clostridium pasteurianum
-
-
-
Daucus carota
-
carrot
-
Dictyostelium discoideum
-
-
-
Escherichia coli
-
-
-
Fasciola hepatica
-
liver fluke, from bile duct of infected cattle
-
Gallus gallus
-
-
-
Glutamicibacter nicotianae
-
-
-
Homo sapiens
-
-
-
Klebsiella aerogenes
-
-
-
Lacticaseibacillus casei
-
-
-
Lactiplantibacillus plantarum
-
-
-
Mus musculus
-
-
-
Neurospora crassa
-
-
-
Oryctolagus cuniculus
-
-
-
Ovis aries
-
-
-
Pisum sativum
-
pea
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-
Thermus thermophilus
-
-
-
Zea mays
-
maize
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus
-
Escherichia coli
-
Homo sapiens
-
Saccharomyces cerevisiae
-
Bos taurus
-
Oryctolagus cuniculus
-
Clostridium pasteurianum

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Rattus norvegicus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Ovis aries
-
Ehrlich ascites carcinoma cell
-
Mus musculus
-
erythrocyte
-
Homo sapiens
-
erythrocyte
-
Oryctolagus cuniculus
-
heart
-
Bos taurus
-
heart
-
Oryctolagus cuniculus
-
heart
-
Ovis aries
-
kidney cortex Oryctolagus cuniculus
-
leaf
-
Brassica oleracea var. gemmifera
-
lens calf Bos taurus
-
leukocyte
-
Homo sapiens
-
liver
-
Gallus gallus
-
liver
-
Homo sapiens
-
liver
-
Oryctolagus cuniculus
-
muscle
-
Homo sapiens
-
muscle
-
Rattus norvegicus
-
muscle
-
Bos taurus
-
muscle
-
Oryctolagus cuniculus
-
muscle
-
Ovis aries
-
mycelium
-
Neurospora crassa
-
platelet
-
Homo sapiens
-
root
-
Daucus carota
-
seed
-
Pisum sativum
-
seed
-
Daucus carota
-
thyroid gland
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
93
-
heart muscle PFK Bos taurus
99.5
-
human skeletal muscle Homo sapiens
114 116
-
Gallus gallus
114 116
-
Saccharomyces cerevisiae
120 160 skeletal muscle PFK Oryctolagus cuniculus
139
-
erythrocyte enzyme Oryctolagus cuniculus
150
-
-
Mus musculus
160
-
-
Oryctolagus cuniculus
160
-
-
Clostridium pasteurianum
160
-
heart PFK Ovis aries
189 215
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,N6-etheno-ATP + D-fructose 6-phosphate
-
Gallus gallus 1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
?
1,N6-etheno-ATP + D-fructose 6-phosphate
-
Mus musculus 1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
?
1,N6-etheno-ATP + D-fructose 6-phosphate
-
Rattus norvegicus 1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
?
1,N6-etheno-ATP + D-fructose 6-phosphate
-
Oryctolagus cuniculus 1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
Gallus gallus 2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
Mus musculus 2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
Rattus norvegicus 2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
Oryctolagus cuniculus 2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
Gallus gallus 6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
Mus musculus 6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
Rattus norvegicus 6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
Oryctolagus cuniculus 6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Gallus gallus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Lactiplantibacillus plantarum ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Mus musculus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Thermus thermophilus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Escherichia coli ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Homo sapiens ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Rattus norvegicus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Saccharomyces cerevisiae ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Bos taurus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Oryctolagus cuniculus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Neurospora crassa ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Ovis aries ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Pisum sativum ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Zea mays ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Klebsiella aerogenes ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Dictyostelium discoideum ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Lacticaseibacillus casei ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Clostridium pasteurianum ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Daucus carota ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Glutamicibacter nicotianae ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Fasciola hepatica ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Arthrobacter crystallopoietes ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate
-
Brassica oleracea var. gemmifera ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Gallus gallus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Lactiplantibacillus plantarum ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Mus musculus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Thermus thermophilus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Escherichia coli ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Homo sapiens ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Rattus norvegicus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Saccharomyces cerevisiae ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Bos taurus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Oryctolagus cuniculus ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Neurospora crassa ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Ovis aries ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Pisum sativum ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Zea mays ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Klebsiella aerogenes ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Dictyostelium discoideum ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Lacticaseibacillus casei ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Clostridium pasteurianum ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Daucus carota ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Glutamicibacter nicotianae ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Fasciola hepatica ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Arthrobacter crystallopoietes ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate Brassica oleracea var. gemmifera ADP + D-fructose 1,6-bisphosphate
-
?
ATP + D-fructose 6-phosphate purine NTPs preferred Brassica oleracea var. gemmifera ADP + D-fructose 1,6-bisphosphate
-
?
ATP + fructose 1-phosphate
-
Escherichia coli ADP + fructose 1,6-bisphosphate
-
?
ATP + fructose 1-phosphate 5% of activity with D-fructose 6-phosphate Oryctolagus cuniculus ADP + fructose 1,6-bisphosphate
-
?
CTP + D-fructose 6-phosphate
-
Escherichia coli CDP + D-fructose 1,6-bisphosphate
-
?
CTP + D-fructose 6-phosphate
-
Saccharomyces cerevisiae CDP + D-fructose 1,6-bisphosphate
-
?
CTP + D-fructose 6-phosphate
-
Oryctolagus cuniculus CDP + D-fructose 1,6-bisphosphate
-
?
CTP + D-fructose 6-phosphate
-
Clostridium pasteurianum CDP + D-fructose 1,6-bisphosphate
-
?
CTP + D-fructose 6-phosphate purine NTPs preferred Brassica oleracea var. gemmifera CDP + D-fructose 1,6-bisphosphate
-
?
dATP + D-fructose 6-phosphate
-
Escherichia coli dADP + D-fructose 1,6-bisphosphate
-
?
GTP + D-fructose 6-phosphate
-
Escherichia coli GDP + D-fructose 1,6-bisphosphate
-
?
GTP + D-fructose 6-phosphate
-
Saccharomyces cerevisiae GDP + D-fructose 1,6-bisphosphate
-
?
GTP + D-fructose 6-phosphate
-
Oryctolagus cuniculus GDP + D-fructose 1,6-bisphosphate
-
?
GTP + D-fructose 6-phosphate
-
Clostridium pasteurianum GDP + D-fructose 1,6-bisphosphate
-
?
GTP + D-fructose 6-phosphate purine NTPs preferred Brassica oleracea var. gemmifera GDP + D-fructose 1,6-bisphosphate
-
?
ITP + D-fructose 6-phosphate
-
Escherichia coli IDP + D-fructose 1,6-bisphosphate
-
?
ITP + D-fructose 6-phosphate
-
Saccharomyces cerevisiae IDP + D-fructose 1,6-bisphosphate
-
?
ITP + D-fructose 6-phosphate
-
Oryctolagus cuniculus IDP + D-fructose 1,6-bisphosphate
-
?
ITP + D-fructose 6-phosphate
-
Clostridium pasteurianum IDP + D-fructose 1,6-bisphosphate
-
?
ITP + D-fructose 6-phosphate purine NTPs preferred Brassica oleracea var. gemmifera IDP + D-fructose 1,6-bisphosphate
-
?
TTP + D-fructose 6-phosphate purine NTPs preferred Escherichia coli TDP + D-fructose 1,6-bisphosphate
-
?
TTP + D-fructose 6-phosphate purine NTPs preferred Brassica oleracea var. gemmifera TDP + D-fructose 1,6-bisphosphate
-
?
UTP + D-fructose 6-phosphate
-
Escherichia coli UDP + D-fructose 1,6-bisphosphate
-
?
UTP + D-fructose 6-phosphate
-
Saccharomyces cerevisiae UDP + D-fructose 1,6-bisphosphate
-
?
UTP + D-fructose 6-phosphate
-
Oryctolagus cuniculus UDP + D-fructose 1,6-bisphosphate
-
?
UTP + D-fructose 6-phosphate
-
Clostridium pasteurianum UDP + D-fructose 1,6-bisphosphate
-
?
UTP + D-fructose 6-phosphate purine NTPs preferred Brassica oleracea var. gemmifera UDP + D-fructose 1,6-bisphosphate
-
?

Subunits

Subunits Comment Organism
?
-
Mus musculus
?
-
Homo sapiens
? x * 36500, sedimentation equilibrium centrifugation in 6 M guanidine Escherichia coli
hexamer 6 * 67000, muscle enzyme, sedimentation equilibrium ultracentrifugation or gel filtration in 6.5 M guanidine Oryctolagus cuniculus
tetramer
-
Rattus norvegicus
tetramer
-
Clostridium pasteurianum
tetramer 4 * 35000, isoenzyme PFK1, tetrahedral arranged subunits, SDS-PAGE Escherichia coli

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
-
-
liver enzyme, 2 h, 80% loss of activity by dissociation of enzyme Gallus gallus
8
-
liver enzyme, 2 h, 60% loss of activity by dissociation of enzyme Gallus gallus
40 60 30 min, stable Gallus gallus
80
-
2 h Thermus thermophilus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
-
Escherichia coli
additional information
-
pH-optimum depends on nucleoside triphosphate substrate Saccharomyces cerevisiae
7.6
-
-
Fasciola hepatica
7.6
-
ITP, optima at pH 7.6 and pH 8.2 Saccharomyces cerevisiae
7.8
-
with ATP Saccharomyces cerevisiae
8.2
-
ITP, optima at pH 7.6 and pH 8.2 Saccharomyces cerevisiae

pH Stability

pH Stability pH Stability Maximum Comment Organism
additional information
-
heart enzyme, mild acidic conditions lead to reversible dissociation and decrease of activity, ATP or fructose 1,6-bisphosphate protects Ovis aries
8
-
-
Oryctolagus cuniculus
8
-
relatively stable to inactivation by dilution, muscle enzyme Ovis aries

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.03
-
citrate brain PFK Rattus norvegicus
0.1
-
cis-aconitate brain PFK Rattus norvegicus
0.2
-
isocitrate brain PFK Rattus norvegicus
0.6
-
malate brain PFK Rattus norvegicus
1.5
-
succinate brain PFK Rattus norvegicus
2.5
-
ATP pH 7.1 Oryctolagus cuniculus
2.5
-
alpha-ketoglutarate brain PFK Rattus norvegicus