BRENDA - Enzyme Database
show all sequences of 2.7.1.11

Phosphofructokinase

Bloxham, D.P.; Lardy, H.A.; The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 8, 239-278 (1973)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
ADP
-
Clostridium pasteurianum
ADP
-
Fasciola hepatica
ADP
-
Rattus norvegicus
ADP
-
Saccharomyces cerevisiae
AMP
-
Bos taurus
AMP
-
Fasciola hepatica
AMP
-
Rattus norvegicus
AMP
-
Saccharomyces cerevisiae
cAMP
-
Fasciola hepatica
cAMP
-
Oryctolagus cuniculus
cAMP
-
Rattus norvegicus
glutathione
activation
Oryctolagus cuniculus
NH4+
-
Clostridium pasteurianum
NH4+
-
Escherichia coli
NH4+
activation of muscle enzyme, inhibitory at high concentrations
Rattus norvegicus
NH4+
-
Saccharomyces cerevisiae
NH4+
-
Fasciola hepatica
NH4+
-
Oryctolagus cuniculus
Crystallization (Commentary)
Crystallization
Organism
-
Saccharomyces cerevisiae
-
Clostridium pasteurianum
-
Gallus gallus
-
Oryctolagus cuniculus
-
Ovis aries
General Stability
General Stability
Organism
dilution reversibly decreases activity
Oryctolagus cuniculus
dilution reversibly decreases activity
Glutamicibacter nicotianae
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-oxoglutarate
brain PFK, not heart PFK
Rattus norvegicus
ADP
plant enzymes
Pisum sativum
ADP
plant enzymes
Zea mays
ADP
-
Clostridium pasteurianum
AMP
-
Brassica oleracea var. gemmifera
AMP
weak inhibition
Daucus carota
AMP
weak inhibition
Lactobacillus plantarum
AMP
weak inhibition
Neurospora crassa
AMP
weak inhibition
Pisum sativum
AMP
-
Zea mays
Antibodies against rabbit muscle enzyme
not rabbit erythrocyte, leukocyte or platelet enzyme
Oryctolagus cuniculus
ATP
-
Escherichia coli
ATP
ADP partially reverses inhibition
Klebsiella aerogenes
ATP
ADP partially reverses inhibition; cAMP partially reverses inhibition; fructose 1,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition
Mus musculus
ATP
muscle PFK, strong inhibition at pH 7.1, weak inhibition at pH 7.6-8.5, not inhibited at pH 9.0
Oryctolagus cuniculus
ATP
fructose 1,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition
Rattus norvegicus
ATP
-
Fasciola hepatica
ATP
-
Saccharomyces cerevisiae
ATP
-
Bos taurus
ATP
-
Ovis aries
ATP
-
Homo sapiens
cAMP
-
Lactobacillus plantarum
cis-aconitate
brain, not heart
Rattus norvegicus
citrate
strong inhibition
Arthrobacter crystallopoietes
citrate
strong inhibition
Bos taurus
citrate
strong inhibition
Brassica oleracea var. gemmifera
citrate
strong inhibition
Clostridium pasteurianum
citrate
strong inhibition
Daucus carota
citrate
strong inhibition
Dictyostelium discoideum
citrate
strong inhibition
Escherichia coli
citrate
strong inhibition
Fasciola hepatica
citrate
strong inhibition
Gallus gallus
citrate
strong inhibition
Glutamicibacter nicotianae
citrate
strong inhibition
Homo sapiens
citrate
strong inhibition
Klebsiella aerogenes
citrate
strong inhibition
Lactobacillus casei
citrate
strong inhibition
Lactobacillus plantarum
citrate
strong inhibition
Mus musculus
citrate
strong inhibition
Neurospora crassa
citrate
strong inhibition
Oryctolagus cuniculus
citrate
strong inhibition
Ovis aries
citrate
strong inhibition
Pisum sativum
citrate
strong inhibition; synergistic with phosphate and AMP
Rattus norvegicus
citrate
strong inhibition
Saccharomyces cerevisiae
citrate
strong inhibition
Thermus thermophilus
citrate
strong inhibition
Zea mays
D-fructose 1,6-bisphosphate
-
Dictyostelium discoideum
D-fructose 1,6-bisphosphate
-
Clostridium pasteurianum
D-Fructose 1-phosphate
-
Arthrobacter crystallopoietes
D-Fructose 1-phosphate
-
Bos taurus
D-Fructose 1-phosphate
-
Brassica oleracea var. gemmifera
D-Fructose 1-phosphate
-
Clostridium pasteurianum
D-Fructose 1-phosphate
-
Daucus carota
D-Fructose 1-phosphate
-
Dictyostelium discoideum
D-Fructose 1-phosphate
-
Escherichia coli
D-Fructose 1-phosphate
-
Fasciola hepatica
D-Fructose 1-phosphate
-
Gallus gallus
D-Fructose 1-phosphate
-
Glutamicibacter nicotianae
D-Fructose 1-phosphate
-
Homo sapiens
D-Fructose 1-phosphate
-
Klebsiella aerogenes
D-Fructose 1-phosphate
-
Lactobacillus casei
D-Fructose 1-phosphate
-
Lactobacillus plantarum
D-Fructose 1-phosphate
-
Mus musculus
D-Fructose 1-phosphate
-
Neurospora crassa
D-Fructose 1-phosphate
-
Oryctolagus cuniculus
D-Fructose 1-phosphate
-
Ovis aries
D-Fructose 1-phosphate
-
Pisum sativum
D-Fructose 1-phosphate
-
Rattus norvegicus
D-Fructose 1-phosphate
-
Saccharomyces cerevisiae
D-Fructose 1-phosphate
-
Thermus thermophilus
D-Fructose 1-phosphate
-
Zea mays
isocitrate
brain, not heart
Rattus norvegicus
malate
kidney cortex, brain, not heart
Rattus norvegicus
Maleic anhydride
muscle and heart enzymes, mechanism
Mus musculus
Maleic anhydride
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
Maleic anhydride
muscle and heart enzymes, mechanism
Rattus norvegicus
Mg2+
brain enzyme, at high concentrations
Mus musculus
Mg2+
brain enzyme, at high concentrations
Oryctolagus cuniculus
Mg2+
brain enzyme, at high concentrations
Rattus norvegicus
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Arthrobacter crystallopoietes
additional information
not inhibited by fructose 1,6-bisphosphate
Bos taurus
additional information
not inhibited by fructose 1,6-bisphosphate
Brassica oleracea var. gemmifera
additional information
not inhibited by fructose 1,6-bisphosphate
Clostridium pasteurianum
additional information
not inhibited by fructose 1,6-bisphosphate
Daucus carota
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Dictyostelium discoideum
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Escherichia coli
additional information
not inhibited by fructose 1,6-bisphosphate
Fasciola hepatica
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Gallus gallus
additional information
not inhibited by fructose 1,6-bisphosphate
Glutamicibacter nicotianae
additional information
not inhibited by fructose 1,6-bisphosphate
Homo sapiens
additional information
not inhibited by fructose 1,6-bisphosphate
Klebsiella aerogenes
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Lactobacillus casei
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Lactobacillus plantarum
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Mus musculus
additional information
not inhibited by fructose 1,6-bisphosphate
Neurospora crassa
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Oryctolagus cuniculus
additional information
not inhibited by fructose 1,6-bisphosphate
Ovis aries
additional information
not inhibited by fructose 1,6-bisphosphate
Pisum sativum
additional information
heart enzyme, not inhibited by cis-aconitate, L-isocitrate, alpha-ketoglutarate, succinate, fumarate, malate, tricarnallylic acid, CoASH, or acetyl-CoASH; not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Rattus norvegicus
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by GTP; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Saccharomyces cerevisiae
additional information
not inhibited by fructose 1,6-bisphosphate
Thermus thermophilus
additional information
not inhibited by fructose 1,6-bisphosphate
Zea mays
NH4+
muscle PFK, weak, at high concentrations, activation at very low concentrations
Oryctolagus cuniculus
phosphoenolpyruvate
-
Mus musculus
phosphoenolpyruvate
-
Rattus norvegicus
phosphoenolpyruvate
-
Escherichia coli
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Mus musculus
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Rattus norvegicus
succinate
kidney cortex and brain PFK, heart PFk is not inhibited
Rattus norvegicus
Succinic anhydride
muscle and heart enzymes, mechanism
Mus musculus
Succinic anhydride
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
Succinic anhydride
muscle and heart enzymes, mechanism
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetic data of various organism
Arthrobacter crystallopoietes
additional information
-
additional information
kinetic data of various organism
Bos taurus
additional information
-
additional information
kinetic data of various organism
Brassica oleracea var. gemmifera
additional information
-
additional information
kinetic data of various organism
Clostridium pasteurianum
additional information
-
additional information
kinetic data of various organism
Daucus carota
additional information
-
additional information
kinetic data of various organism
Dictyostelium discoideum
additional information
-
additional information
kinetic data of various organism
Escherichia coli
additional information
-
additional information
kinetic data of various organism
Fasciola hepatica
additional information
-
additional information
kinetic data of various organism
Gallus gallus
additional information
-
additional information
kinetic data of various organism
Glutamicibacter nicotianae
additional information
-
additional information
kinetic data of various organism
Homo sapiens
additional information
-
additional information
kinetic data of various organism
Klebsiella aerogenes
additional information
-
additional information
kinetic data of various organism
Lactobacillus casei
additional information
-
additional information
kinetic data of various organism
Lactobacillus plantarum
additional information
-
additional information
kinetic data of various organism
Mus musculus
additional information
-
additional information
kinetic data of various organism
Neurospora crassa
additional information
-
additional information
kinetic data of various organism
Oryctolagus cuniculus
additional information
-
additional information
kinetic data of various organism
Ovis aries
additional information
-
additional information
kinetic data of various organism
Pisum sativum
additional information
-
additional information
kinetic data of various organism
Rattus norvegicus
additional information
-
additional information
kinetic data of various organism
Saccharomyces cerevisiae
additional information
-
additional information
kinetic data of various organism
Thermus thermophilus
additional information
-
additional information
kinetic data of various organism
Zea mays
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Arthrobacter crystallopoietes
5829
-
cytosol
-
Bos taurus
5829
-
cytosol
-
Brassica oleracea var. gemmifera
5829
-
cytosol
-
Clostridium pasteurianum
5829
-
cytosol
-
Daucus carota
5829
-
cytosol
-
Dictyostelium discoideum
5829
-
cytosol
-
Escherichia coli
5829
-
cytosol
-
Fasciola hepatica
5829
-
cytosol
-
Gallus gallus
5829
-
cytosol
-
Glutamicibacter nicotianae
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Klebsiella aerogenes
5829
-
cytosol
-
Lactobacillus casei
5829
-
cytosol
-
Lactobacillus plantarum
5829
-
cytosol
-
Mus musculus
5829
-
cytosol
-
Neurospora crassa
5829
-
cytosol
-
Ovis aries
5829
-
cytosol
-
Pisum sativum
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Saccharomyces cerevisiae
5829
-
cytosol
-
Thermus thermophilus
5829
-
cytosol
-
Zea mays
5829
-
cytosol
-
Oryctolagus cuniculus
5829
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Co2+
-
Arthrobacter crystallopoietes
Co2+
-
Bos taurus
Co2+
-
Brassica oleracea var. gemmifera
Co2+
-
Daucus carota
Co2+
-
Dictyostelium discoideum
Co2+
-
Escherichia coli
Co2+
-
Fasciola hepatica
Co2+
-
Gallus gallus
Co2+
-
Glutamicibacter nicotianae
Co2+
-
Homo sapiens
Co2+
-
Klebsiella aerogenes
Co2+
-
Lactobacillus casei
Co2+
-
Lactobacillus plantarum
Co2+
-
Mus musculus
Co2+
-
Neurospora crassa
Co2+
-
Oryctolagus cuniculus
Co2+
-
Ovis aries
Co2+
-
Pisum sativum
Co2+
-
Rattus norvegicus
Co2+
-
Saccharomyces cerevisiae
Co2+
-
Thermus thermophilus
Co2+
-
Zea mays
Co2+
-
Clostridium pasteurianum
K+
-
Arthrobacter crystallopoietes
K+
-
Brassica oleracea var. gemmifera
K+
-
Clostridium pasteurianum
K+
-
Daucus carota
K+
-
Dictyostelium discoideum
K+
-
Escherichia coli
K+
-
Glutamicibacter nicotianae
K+
-
Klebsiella aerogenes
K+
-
Lactobacillus casei
K+
-
Lactobacillus plantarum
K+
-
Mus musculus
K+
-
Neurospora crassa
K+
-
Pisum sativum
K+
-
Rattus norvegicus
K+
-
Thermus thermophilus
K+
-
Zea mays
K+
-
Fasciola hepatica
K+
-
Saccharomyces cerevisiae
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Arthrobacter crystallopoietes
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Bos taurus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Brassica oleracea var. gemmifera
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Clostridium pasteurianum
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Daucus carota
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Dictyostelium discoideum
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Escherichia coli
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Fasciola hepatica
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Gallus gallus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Glutamicibacter nicotianae
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Homo sapiens
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Klebsiella aerogenes
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Lactobacillus casei
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Lactobacillus plantarum
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Mus musculus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Neurospora crassa
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Oryctolagus cuniculus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Ovis aries
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Pisum sativum
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Rattus norvegicus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Saccharomyces cerevisiae
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Thermus thermophilus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Zea mays
Mn2+
activation
Arthrobacter crystallopoietes
Mn2+
activation
Bos taurus
Mn2+
activation
Brassica oleracea var. gemmifera
Mn2+
activation
Daucus carota
Mn2+
activation
Dictyostelium discoideum
Mn2+
activation
Escherichia coli
Mn2+
activation
Fasciola hepatica
Mn2+
activation
Gallus gallus
Mn2+
activation
Glutamicibacter nicotianae
Mn2+
activation
Homo sapiens
Mn2+
activation
Klebsiella aerogenes
Mn2+
activation
Lactobacillus casei
Mn2+
activation
Lactobacillus plantarum
Mn2+
activation
Mus musculus
Mn2+
activation
Neurospora crassa
Mn2+
activation
Oryctolagus cuniculus
Mn2+
activation
Ovis aries
Mn2+
activation
Pisum sativum
Mn2+
activation
Rattus norvegicus
Mn2+
activation
Saccharomyces cerevisiae
Mn2+
activation
Thermus thermophilus
Mn2+
activation
Zea mays
Mn2+
activation
Clostridium pasteurianum
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
4 * 35000, isoenzyme PFK1, tetrahedral arranged subunits, SDS-PAGE
Escherichia coli
36500
-
x * 36500, sedimentation equilibrium centrifugation in 6 M guanidine
Escherichia coli
67000
-
6 * 67000, muscle enzyme, sedimentation equilibrium ultracentrifugation or gel filtration in 6.5 M guanidine
Oryctolagus cuniculus
141000
142000
-
Escherichia coli
144000
-
-
Clostridium pasteurianum
300000
-
gel filtration
Mus musculus
380000
-
skeletal muscle
Oryctolagus cuniculus
380000
-
-
Rattus norvegicus
500000
-
erythrocyte, sucrose density gradient centrifugation
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + D-fructose 6-phosphate
Gallus gallus
-
ADP + D-fructose 1,6-bisphosphate
-
Gallus gallus
?
ATP + D-fructose 6-phosphate
Lactobacillus plantarum
-
ADP + D-fructose 1,6-bisphosphate
-
Lactobacillus plantarum
?
ATP + D-fructose 6-phosphate
Mus musculus
-
ADP + D-fructose 1,6-bisphosphate
-
Mus musculus
?
ATP + D-fructose 6-phosphate
Thermus thermophilus
-
ADP + D-fructose 1,6-bisphosphate
-
Thermus thermophilus
?
ATP + D-fructose 6-phosphate
Escherichia coli
-
ADP + D-fructose 1,6-bisphosphate
-
Escherichia coli
?
ATP + D-fructose 6-phosphate
Homo sapiens
-
ADP + D-fructose 1,6-bisphosphate
-
Homo sapiens
?
ATP + D-fructose 6-phosphate
Rattus norvegicus
-
ADP + D-fructose 1,6-bisphosphate
-
Rattus norvegicus
?
ATP + D-fructose 6-phosphate
Saccharomyces cerevisiae
-
ADP + D-fructose 1,6-bisphosphate
-
Saccharomyces cerevisiae
?
ATP + D-fructose 6-phosphate
Bos taurus
-
ADP + D-fructose 1,6-bisphosphate
-
Bos taurus
?
ATP + D-fructose 6-phosphate
Oryctolagus cuniculus
-
ADP + D-fructose 1,6-bisphosphate
-
Oryctolagus cuniculus
?
ATP + D-fructose 6-phosphate
Neurospora crassa
-
ADP + D-fructose 1,6-bisphosphate
-
Neurospora crassa
?
ATP + D-fructose 6-phosphate
Ovis aries
-
ADP + D-fructose 1,6-bisphosphate
-
Ovis aries
?
ATP + D-fructose 6-phosphate
Pisum sativum
-
ADP + D-fructose 1,6-bisphosphate
-
Pisum sativum
?
ATP + D-fructose 6-phosphate
Zea mays
-
ADP + D-fructose 1,6-bisphosphate
-
Zea mays
?
ATP + D-fructose 6-phosphate
Klebsiella aerogenes
-
ADP + D-fructose 1,6-bisphosphate
-
Klebsiella aerogenes
?
ATP + D-fructose 6-phosphate
Dictyostelium discoideum
-
ADP + D-fructose 1,6-bisphosphate
-
Dictyostelium discoideum
?
ATP + D-fructose 6-phosphate
Lactobacillus casei
-
ADP + D-fructose 1,6-bisphosphate
-
Lactobacillus casei
?
ATP + D-fructose 6-phosphate
Clostridium pasteurianum
-
ADP + D-fructose 1,6-bisphosphate
-
Clostridium pasteurianum
?
ATP + D-fructose 6-phosphate
Daucus carota
-
ADP + D-fructose 1,6-bisphosphate
-
Daucus carota
?
ATP + D-fructose 6-phosphate
Glutamicibacter nicotianae
-
ADP + D-fructose 1,6-bisphosphate
-
Glutamicibacter nicotianae
?
ATP + D-fructose 6-phosphate
Fasciola hepatica
-
ADP + D-fructose 1,6-bisphosphate
-
Fasciola hepatica
?
ATP + D-fructose 6-phosphate
Arthrobacter crystallopoietes
-
ADP + D-fructose 1,6-bisphosphate
-
Arthrobacter crystallopoietes
?
ATP + D-fructose 6-phosphate
Brassica oleracea var. gemmifera
-
ADP + D-fructose 1,6-bisphosphate
-
Brassica oleracea var. gemmifera
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arthrobacter crystallopoietes
-
-
-
Bos taurus
-
calf; ox
-
Brassica oleracea var. gemmifera
-
Brussel's sprout
-
Clostridium pasteurianum
-
-
-
Daucus carota
-
carrot
-
Dictyostelium discoideum
-
-
-
Escherichia coli
-
-
-
Fasciola hepatica
-
liver fluke, from bile duct of infected cattle
-
Gallus gallus
-
-
-
Glutamicibacter nicotianae
-
-
-
Homo sapiens
-
-
-
Klebsiella aerogenes
-
-
-
Lactobacillus casei
-
-
-
Lactobacillus plantarum
-
-
-
Mus musculus
-
-
-
Neurospora crassa
-
-
-
Oryctolagus cuniculus
-
-
-
Ovis aries
-
-
-
Pisum sativum
-
pea
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-
Thermus thermophilus
-
-
-
Zea mays
-
maize
-
Purification (Commentary)
Commentary
Organism
-
Clostridium pasteurianum
-
Homo sapiens
-
Mus musculus
-
Saccharomyces cerevisiae
-
Oryctolagus cuniculus
-
Bos taurus
-
Escherichia coli
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adipose tissue
-
Rattus norvegicus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Ovis aries
-
Ehrlich ascites carcinoma cell
-
Mus musculus
-
erythrocyte
-
Oryctolagus cuniculus
-
erythrocyte
-
Homo sapiens
-
heart
-
Bos taurus
-
heart
-
Oryctolagus cuniculus
-
heart
-
Ovis aries
-
kidney
cortex
Oryctolagus cuniculus
-
leaf
-
Brassica oleracea var. gemmifera
-
lens
calf
Bos taurus
-
leukocyte
-
Homo sapiens
-
liver
-
Gallus gallus
-
liver
-
Homo sapiens
-
liver
-
Oryctolagus cuniculus
-
muscle
-
Ovis aries
-
muscle
-
Rattus norvegicus
-
muscle
-
Bos taurus
-
muscle
-
Homo sapiens
-
muscle
-
Oryctolagus cuniculus
-
mycelium
-
Neurospora crassa
-
platelet
-
Homo sapiens
-
root
-
Daucus carota
-
seed
-
Daucus carota
-
seed
-
Pisum sativum
-
thyroid gland
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
93
-
heart muscle PFK
Bos taurus
99.5
-
human skeletal muscle
Homo sapiens
114
116
-
Gallus gallus
114
116
-
Saccharomyces cerevisiae
120
160
skeletal muscle PFK
Oryctolagus cuniculus
139
-
erythrocyte enzyme
Oryctolagus cuniculus
150
-
-
Mus musculus
160
-
-
Clostridium pasteurianum
160
-
-
Oryctolagus cuniculus
160
-
heart PFK
Ovis aries
189
215
-
Escherichia coli
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Gallus gallus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Mus musculus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Rattus norvegicus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Gallus gallus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Mus musculus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Rattus norvegicus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Gallus gallus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Mus musculus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Rattus norvegicus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
ATP + D-fructose 6-phosphate
-
640421
Gallus gallus
ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
ATP + D-fructose 6-phosphate
-
640421
Lactobacillus plantarum
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus plantarum
?
ATP + D-fructose 6-phosphate
-
640421
Mus musculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
ATP + D-fructose 6-phosphate
-
640421
Thermus thermophilus
ADP + D-fructose 1,6-bisphosphate
-
640421
Thermus thermophilus
?
ATP + D-fructose 6-phosphate
-
640421
Escherichia coli
ADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
ATP + D-fructose 6-phosphate
-
640421
Homo sapiens
ADP + D-fructose 1,6-bisphosphate
-
640421
Homo sapiens
?
ATP + D-fructose 6-phosphate
-
640421
Rattus norvegicus
ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
ATP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
ADP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
ATP + D-fructose 6-phosphate
-
640421
Bos taurus
ADP + D-fructose 1,6-bisphosphate
-
640421
Bos taurus
?
ATP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
ATP + D-fructose 6-phosphate
-
640421
Neurospora crassa
ADP + D-fructose 1,6-bisphosphate
-
640421
Neurospora crassa
?
ATP + D-fructose 6-phosphate
-
640421
Ovis aries
ADP + D-fructose 1,6-bisphosphate
-
640421
Ovis aries
?
ATP + D-fructose 6-phosphate
-
640421
Pisum sativum
ADP + D-fructose 1,6-bisphosphate
-
640421
Pisum sativum
?
ATP + D-fructose 6-phosphate
-
640421
Zea mays
ADP + D-fructose 1,6-bisphosphate
-
640421
Zea mays
?
ATP + D-fructose 6-phosphate
-
640421
Klebsiella aerogenes
ADP + D-fructose 1,6-bisphosphate
-
640421
Klebsiella aerogenes
?
ATP + D-fructose 6-phosphate
-
640421
Dictyostelium discoideum
ADP + D-fructose 1,6-bisphosphate
-
640421
Dictyostelium discoideum
?
ATP + D-fructose 6-phosphate
-
640421
Lactobacillus casei
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus casei
?
ATP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
ADP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
ATP + D-fructose 6-phosphate
-
640421
Daucus carota
ADP + D-fructose 1,6-bisphosphate
-
640421
Daucus carota
?
ATP + D-fructose 6-phosphate
-
640421
Glutamicibacter nicotianae
ADP + D-fructose 1,6-bisphosphate
-
640421
Glutamicibacter nicotianae
?
ATP + D-fructose 6-phosphate
-
640421
Fasciola hepatica
ADP + D-fructose 1,6-bisphosphate
-
640421
Fasciola hepatica
?
ATP + D-fructose 6-phosphate
-
640421
Arthrobacter crystallopoietes
ADP + D-fructose 1,6-bisphosphate
-
640421
Arthrobacter crystallopoietes
?
ATP + D-fructose 6-phosphate
-
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Gallus gallus
ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Lactobacillus plantarum
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus plantarum
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Mus musculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Thermus thermophilus
ADP + D-fructose 1,6-bisphosphate
-
640421
Thermus thermophilus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Escherichia coli
ADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Homo sapiens
ADP + D-fructose 1,6-bisphosphate
-
640421
Homo sapiens
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Rattus norvegicus
ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Saccharomyces cerevisiae
ADP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Bos taurus
ADP + D-fructose 1,6-bisphosphate
-
640421
Bos taurus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Oryctolagus cuniculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Neurospora crassa
ADP + D-fructose 1,6-bisphosphate
-
640421
Neurospora crassa
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Ovis aries
ADP + D-fructose 1,6-bisphosphate
-
640421
Ovis aries
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Pisum sativum
ADP + D-fructose 1,6-bisphosphate
-
640421
Pisum sativum
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Zea mays
ADP + D-fructose 1,6-bisphosphate
-
640421
Zea mays
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Klebsiella aerogenes
ADP + D-fructose 1,6-bisphosphate
-
640421
Klebsiella aerogenes
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Dictyostelium discoideum
ADP + D-fructose 1,6-bisphosphate
-
640421
Dictyostelium discoideum
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Lactobacillus casei
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus casei
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Clostridium pasteurianum
ADP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Daucus carota
ADP + D-fructose 1,6-bisphosphate
-
640421
Daucus carota
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Glutamicibacter nicotianae
ADP + D-fructose 1,6-bisphosphate
-
640421
Glutamicibacter nicotianae
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Fasciola hepatica
ADP + D-fructose 1,6-bisphosphate
-
640421
Fasciola hepatica
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Arthrobacter crystallopoietes
ADP + D-fructose 1,6-bisphosphate
-
640421
Arthrobacter crystallopoietes
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
ATP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
ATP + fructose 1-phosphate
-
640421
Escherichia coli
ADP + fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
ATP + fructose 1-phosphate
5% of activity with D-fructose 6-phosphate
640421
Oryctolagus cuniculus
ADP + fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
CTP + D-fructose 6-phosphate
-
640421
Escherichia coli
CDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
CTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
CDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
CTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
CDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
CTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
CDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
CTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
CDP + D-fructose 1,6-bisphosphate
-
-
-
-
dATP + D-fructose 6-phosphate
-
640421
Escherichia coli
dADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
GTP + D-fructose 6-phosphate
-
640421
Escherichia coli
GDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
GTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
GDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
GTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
GDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
GTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
GDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
GTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
GDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
ITP + D-fructose 6-phosphate
-
640421
Escherichia coli
IDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
ITP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
IDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
ITP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
IDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
ITP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
IDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
ITP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
IDP + D-fructose 1,6-bisphosphate
-
-
-
-
TTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Escherichia coli
TDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
TTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
TDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
UTP + D-fructose 6-phosphate
-
640421
Escherichia coli
UDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
UTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
UDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
UTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
UDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
UTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
UDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
UTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
UDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
Subunits
Subunits
Commentary
Organism
?
x * 36500, sedimentation equilibrium centrifugation in 6 M guanidine
Escherichia coli
?
-
Homo sapiens
?
-
Mus musculus
hexamer
6 * 67000, muscle enzyme, sedimentation equilibrium ultracentrifugation or gel filtration in 6.5 M guanidine
Oryctolagus cuniculus
tetramer
-
Clostridium pasteurianum
tetramer
4 * 35000, isoenzyme PFK1, tetrahedral arranged subunits, SDS-PAGE
Escherichia coli
tetramer
-
Rattus norvegicus
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
-
-
liver enzyme, 2 h, 80% loss of activity by dissociation of enzyme
Gallus gallus
8
-
liver enzyme, 2 h, 60% loss of activity by dissociation of enzyme
Gallus gallus
40
60
30 min, stable
Gallus gallus
80
-
2 h
Thermus thermophilus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
additional information
-
-
Escherichia coli
additional information
-
pH-optimum depends on nucleoside triphosphate substrate
Saccharomyces cerevisiae
7.6
-
-
Fasciola hepatica
7.6
-
ITP, optima at pH 7.6 and pH 8.2
Saccharomyces cerevisiae
7.8
-
with ATP
Saccharomyces cerevisiae
8.2
-
ITP, optima at pH 7.6 and pH 8.2
Saccharomyces cerevisiae
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
additional information
-
heart enzyme, mild acidic conditions lead to reversible dissociation and decrease of activity, ATP or fructose 1,6-bisphosphate protects
Ovis aries
8
-
-
Oryctolagus cuniculus
8
-
relatively stable to inactivation by dilution, muscle enzyme
Ovis aries
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.03
-
citrate
brain PFK
Rattus norvegicus
0.1
-
cis-aconitate
brain PFK
Rattus norvegicus
0.2
-
isocitrate
brain PFK
Rattus norvegicus
0.6
-
malate
brain PFK
Rattus norvegicus
1.5
-
succinate
brain PFK
Rattus norvegicus
2.5
-
alpha-ketoglutarate
brain PFK
Rattus norvegicus
2.5
-
ATP
pH 7.1
Oryctolagus cuniculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
ADP
-
Clostridium pasteurianum
ADP
-
Fasciola hepatica
ADP
-
Rattus norvegicus
ADP
-
Saccharomyces cerevisiae
AMP
-
Bos taurus
AMP
-
Fasciola hepatica
AMP
-
Rattus norvegicus
AMP
-
Saccharomyces cerevisiae
cAMP
-
Fasciola hepatica
cAMP
-
Oryctolagus cuniculus
cAMP
-
Rattus norvegicus
glutathione
activation
Oryctolagus cuniculus
NH4+
-
Clostridium pasteurianum
NH4+
-
Escherichia coli
NH4+
activation of muscle enzyme, inhibitory at high concentrations
Rattus norvegicus
NH4+
-
Saccharomyces cerevisiae
NH4+
-
Fasciola hepatica
NH4+
-
Oryctolagus cuniculus
Crystallization (Commentary) (protein specific)
Crystallization
Organism
-
Saccharomyces cerevisiae
-
Clostridium pasteurianum
-
Gallus gallus
-
Oryctolagus cuniculus
-
Ovis aries
General Stability (protein specific)
General Stability
Organism
dilution reversibly decreases activity
Oryctolagus cuniculus
dilution reversibly decreases activity
Glutamicibacter nicotianae
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-oxoglutarate
brain PFK, not heart PFK
Rattus norvegicus
ADP
plant enzymes
Pisum sativum
ADP
plant enzymes
Zea mays
ADP
-
Clostridium pasteurianum
AMP
-
Brassica oleracea var. gemmifera
AMP
weak inhibition
Daucus carota
AMP
weak inhibition
Lactobacillus plantarum
AMP
weak inhibition
Neurospora crassa
AMP
weak inhibition
Pisum sativum
AMP
-
Zea mays
Antibodies against rabbit muscle enzyme
not rabbit erythrocyte, leukocyte or platelet enzyme
Oryctolagus cuniculus
ATP
-
Escherichia coli
ATP
ADP partially reverses inhibition
Klebsiella aerogenes
ATP
ADP partially reverses inhibition; cAMP partially reverses inhibition; fructose 1,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition
Mus musculus
ATP
muscle PFK, strong inhibition at pH 7.1, weak inhibition at pH 7.6-8.5, not inhibited at pH 9.0
Oryctolagus cuniculus
ATP
fructose 1,6-bisphosphate partially reverses inhibition; phosphate and AMP partially reverse inhibition
Rattus norvegicus
ATP
-
Fasciola hepatica
ATP
-
Saccharomyces cerevisiae
ATP
-
Bos taurus
ATP
-
Ovis aries
ATP
-
Homo sapiens
cAMP
-
Lactobacillus plantarum
cis-aconitate
brain, not heart
Rattus norvegicus
citrate
strong inhibition
Arthrobacter crystallopoietes
citrate
strong inhibition
Bos taurus
citrate
strong inhibition
Brassica oleracea var. gemmifera
citrate
strong inhibition
Clostridium pasteurianum
citrate
strong inhibition
Daucus carota
citrate
strong inhibition
Dictyostelium discoideum
citrate
strong inhibition
Escherichia coli
citrate
strong inhibition
Fasciola hepatica
citrate
strong inhibition
Gallus gallus
citrate
strong inhibition
Glutamicibacter nicotianae
citrate
strong inhibition
Homo sapiens
citrate
strong inhibition
Klebsiella aerogenes
citrate
strong inhibition
Lactobacillus casei
citrate
strong inhibition
Lactobacillus plantarum
citrate
strong inhibition
Mus musculus
citrate
strong inhibition
Neurospora crassa
citrate
strong inhibition
Oryctolagus cuniculus
citrate
strong inhibition
Ovis aries
citrate
strong inhibition
Pisum sativum
citrate
strong inhibition; synergistic with phosphate and AMP
Rattus norvegicus
citrate
strong inhibition
Saccharomyces cerevisiae
citrate
strong inhibition
Thermus thermophilus
citrate
strong inhibition
Zea mays
D-fructose 1,6-bisphosphate
-
Dictyostelium discoideum
D-fructose 1,6-bisphosphate
-
Clostridium pasteurianum
D-Fructose 1-phosphate
-
Arthrobacter crystallopoietes
D-Fructose 1-phosphate
-
Bos taurus
D-Fructose 1-phosphate
-
Brassica oleracea var. gemmifera
D-Fructose 1-phosphate
-
Clostridium pasteurianum
D-Fructose 1-phosphate
-
Daucus carota
D-Fructose 1-phosphate
-
Dictyostelium discoideum
D-Fructose 1-phosphate
-
Escherichia coli
D-Fructose 1-phosphate
-
Fasciola hepatica
D-Fructose 1-phosphate
-
Gallus gallus
D-Fructose 1-phosphate
-
Glutamicibacter nicotianae
D-Fructose 1-phosphate
-
Homo sapiens
D-Fructose 1-phosphate
-
Klebsiella aerogenes
D-Fructose 1-phosphate
-
Lactobacillus casei
D-Fructose 1-phosphate
-
Lactobacillus plantarum
D-Fructose 1-phosphate
-
Mus musculus
D-Fructose 1-phosphate
-
Neurospora crassa
D-Fructose 1-phosphate
-
Oryctolagus cuniculus
D-Fructose 1-phosphate
-
Ovis aries
D-Fructose 1-phosphate
-
Pisum sativum
D-Fructose 1-phosphate
-
Rattus norvegicus
D-Fructose 1-phosphate
-
Saccharomyces cerevisiae
D-Fructose 1-phosphate
-
Thermus thermophilus
D-Fructose 1-phosphate
-
Zea mays
isocitrate
brain, not heart
Rattus norvegicus
malate
kidney cortex, brain, not heart
Rattus norvegicus
Maleic anhydride
muscle and heart enzymes, mechanism
Mus musculus
Maleic anhydride
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
Maleic anhydride
muscle and heart enzymes, mechanism
Rattus norvegicus
Mg2+
brain enzyme, at high concentrations
Mus musculus
Mg2+
brain enzyme, at high concentrations
Oryctolagus cuniculus
Mg2+
brain enzyme, at high concentrations
Rattus norvegicus
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Arthrobacter crystallopoietes
additional information
not inhibited by fructose 1,6-bisphosphate
Bos taurus
additional information
not inhibited by fructose 1,6-bisphosphate
Brassica oleracea var. gemmifera
additional information
not inhibited by fructose 1,6-bisphosphate
Clostridium pasteurianum
additional information
not inhibited by fructose 1,6-bisphosphate
Daucus carota
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Dictyostelium discoideum
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Escherichia coli
additional information
not inhibited by fructose 1,6-bisphosphate
Fasciola hepatica
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Gallus gallus
additional information
not inhibited by fructose 1,6-bisphosphate
Glutamicibacter nicotianae
additional information
not inhibited by fructose 1,6-bisphosphate
Homo sapiens
additional information
not inhibited by fructose 1,6-bisphosphate
Klebsiella aerogenes
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Lactobacillus casei
additional information
not inhibited by ATP; not inhibited by fructose 1,6-bisphosphate
Lactobacillus plantarum
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Mus musculus
additional information
not inhibited by fructose 1,6-bisphosphate
Neurospora crassa
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Oryctolagus cuniculus
additional information
not inhibited by fructose 1,6-bisphosphate
Ovis aries
additional information
not inhibited by fructose 1,6-bisphosphate
Pisum sativum
additional information
heart enzyme, not inhibited by cis-aconitate, L-isocitrate, alpha-ketoglutarate, succinate, fumarate, malate, tricarnallylic acid, CoASH, or acetyl-CoASH; not inhibited by fructose 1,6-bisphosphate; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA; photooxidation yields a new heart enzyme species that is no longer sensitive to ATP
Rattus norvegicus
additional information
not inhibited by fructose 1,6-bisphosphate; not inhibited by GTP; not inhibited by ITP, fumarate, tricarballylic acid, CoA, acetyl-CoA
Saccharomyces cerevisiae
additional information
not inhibited by fructose 1,6-bisphosphate
Thermus thermophilus
additional information
not inhibited by fructose 1,6-bisphosphate
Zea mays
NH4+
muscle PFK, weak, at high concentrations, activation at very low concentrations
Oryctolagus cuniculus
phosphoenolpyruvate
-
Mus musculus
phosphoenolpyruvate
-
Escherichia coli
phosphoenolpyruvate
-
Rattus norvegicus
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Mus musculus
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
pyridoxal 5'-phosphate
muscle and heart enzymes, mechanism
Rattus norvegicus
succinate
kidney cortex and brain PFK, heart PFk is not inhibited
Rattus norvegicus
Succinic anhydride
muscle and heart enzymes, mechanism
Mus musculus
Succinic anhydride
muscle and heart enzymes, mechanism
Oryctolagus cuniculus
Succinic anhydride
muscle and heart enzymes, mechanism
Rattus norvegicus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.03
-
citrate
brain PFK
Rattus norvegicus
0.1
-
cis-aconitate
brain PFK
Rattus norvegicus
0.2
-
isocitrate
brain PFK
Rattus norvegicus
0.6
-
malate
brain PFK
Rattus norvegicus
1.5
-
succinate
brain PFK
Rattus norvegicus
2.5
-
alpha-ketoglutarate
brain PFK
Rattus norvegicus
2.5
-
ATP
pH 7.1
Oryctolagus cuniculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetic data of various organism
Arthrobacter crystallopoietes
additional information
-
additional information
kinetic data of various organism
Bos taurus
additional information
-
additional information
kinetic data of various organism
Brassica oleracea var. gemmifera
additional information
-
additional information
kinetic data of various organism
Clostridium pasteurianum
additional information
-
additional information
kinetic data of various organism
Daucus carota
additional information
-
additional information
kinetic data of various organism
Dictyostelium discoideum
additional information
-
additional information
kinetic data of various organism
Escherichia coli
additional information
-
additional information
kinetic data of various organism
Fasciola hepatica
additional information
-
additional information
kinetic data of various organism
Gallus gallus
additional information
-
additional information
kinetic data of various organism
Glutamicibacter nicotianae
additional information
-
additional information
kinetic data of various organism
Homo sapiens
additional information
-
additional information
kinetic data of various organism
Klebsiella aerogenes
additional information
-
additional information
kinetic data of various organism
Lactobacillus casei
additional information
-
additional information
kinetic data of various organism
Lactobacillus plantarum
additional information
-
additional information
kinetic data of various organism
Mus musculus
additional information
-
additional information
kinetic data of various organism
Neurospora crassa
additional information
-
additional information
kinetic data of various organism
Oryctolagus cuniculus
additional information
-
additional information
kinetic data of various organism
Ovis aries
additional information
-
additional information
kinetic data of various organism
Pisum sativum
additional information
-
additional information
kinetic data of various organism
Rattus norvegicus
additional information
-
additional information
kinetic data of various organism
Saccharomyces cerevisiae
additional information
-
additional information
kinetic data of various organism
Thermus thermophilus
additional information
-
additional information
kinetic data of various organism
Zea mays
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Arthrobacter crystallopoietes
5829
-
cytosol
-
Bos taurus
5829
-
cytosol
-
Brassica oleracea var. gemmifera
5829
-
cytosol
-
Clostridium pasteurianum
5829
-
cytosol
-
Daucus carota
5829
-
cytosol
-
Dictyostelium discoideum
5829
-
cytosol
-
Escherichia coli
5829
-
cytosol
-
Fasciola hepatica
5829
-
cytosol
-
Gallus gallus
5829
-
cytosol
-
Glutamicibacter nicotianae
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Klebsiella aerogenes
5829
-
cytosol
-
Lactobacillus casei
5829
-
cytosol
-
Lactobacillus plantarum
5829
-
cytosol
-
Mus musculus
5829
-
cytosol
-
Neurospora crassa
5829
-
cytosol
-
Ovis aries
5829
-
cytosol
-
Pisum sativum
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Saccharomyces cerevisiae
5829
-
cytosol
-
Thermus thermophilus
5829
-
cytosol
-
Zea mays
5829
-
cytosol
-
Oryctolagus cuniculus
5829
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Co2+
-
Arthrobacter crystallopoietes
Co2+
-
Bos taurus
Co2+
-
Brassica oleracea var. gemmifera
Co2+
-
Daucus carota
Co2+
-
Dictyostelium discoideum
Co2+
-
Escherichia coli
Co2+
-
Fasciola hepatica
Co2+
-
Gallus gallus
Co2+
-
Glutamicibacter nicotianae
Co2+
-
Homo sapiens
Co2+
-
Klebsiella aerogenes
Co2+
-
Lactobacillus casei
Co2+
-
Lactobacillus plantarum
Co2+
-
Mus musculus
Co2+
-
Neurospora crassa
Co2+
-
Oryctolagus cuniculus
Co2+
-
Ovis aries
Co2+
-
Pisum sativum
Co2+
-
Rattus norvegicus
Co2+
-
Saccharomyces cerevisiae
Co2+
-
Thermus thermophilus
Co2+
-
Zea mays
Co2+
-
Clostridium pasteurianum
K+
-
Arthrobacter crystallopoietes
K+
-
Brassica oleracea var. gemmifera
K+
-
Clostridium pasteurianum
K+
-
Daucus carota
K+
-
Dictyostelium discoideum
K+
-
Escherichia coli
K+
-
Glutamicibacter nicotianae
K+
-
Klebsiella aerogenes
K+
-
Lactobacillus casei
K+
-
Lactobacillus plantarum
K+
-
Mus musculus
K+
-
Neurospora crassa
K+
-
Pisum sativum
K+
-
Rattus norvegicus
K+
-
Thermus thermophilus
K+
-
Zea mays
K+
-
Fasciola hepatica
K+
-
Saccharomyces cerevisiae
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Arthrobacter crystallopoietes
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Bos taurus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Brassica oleracea var. gemmifera
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Clostridium pasteurianum
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Daucus carota
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Dictyostelium discoideum
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Escherichia coli
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Fasciola hepatica
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Gallus gallus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Glutamicibacter nicotianae
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Homo sapiens
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Klebsiella aerogenes
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Lactobacillus casei
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Lactobacillus plantarum
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Mus musculus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Neurospora crassa
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Oryctolagus cuniculus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Ovis aries
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Pisum sativum
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Rattus norvegicus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Saccharomyces cerevisiae
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Thermus thermophilus
Mg2+
MgATP is the active substrate; most effective ion; required for activity
Zea mays
Mn2+
activation
Arthrobacter crystallopoietes
Mn2+
activation
Bos taurus
Mn2+
activation
Brassica oleracea var. gemmifera
Mn2+
activation
Daucus carota
Mn2+
activation
Dictyostelium discoideum
Mn2+
activation
Escherichia coli
Mn2+
activation
Fasciola hepatica
Mn2+
activation
Gallus gallus
Mn2+
activation
Glutamicibacter nicotianae
Mn2+
activation
Homo sapiens
Mn2+
activation
Klebsiella aerogenes
Mn2+
activation
Lactobacillus casei
Mn2+
activation
Lactobacillus plantarum
Mn2+
activation
Mus musculus
Mn2+
activation
Neurospora crassa
Mn2+
activation
Oryctolagus cuniculus
Mn2+
activation
Ovis aries
Mn2+
activation
Pisum sativum
Mn2+
activation
Rattus norvegicus
Mn2+
activation
Saccharomyces cerevisiae
Mn2+
activation
Thermus thermophilus
Mn2+
activation
Zea mays
Mn2+
activation
Clostridium pasteurianum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
4 * 35000, isoenzyme PFK1, tetrahedral arranged subunits, SDS-PAGE
Escherichia coli
36500
-
x * 36500, sedimentation equilibrium centrifugation in 6 M guanidine
Escherichia coli
67000
-
6 * 67000, muscle enzyme, sedimentation equilibrium ultracentrifugation or gel filtration in 6.5 M guanidine
Oryctolagus cuniculus
141000
142000
-
Escherichia coli
144000
-
-
Clostridium pasteurianum
300000
-
gel filtration
Mus musculus
380000
-
skeletal muscle
Oryctolagus cuniculus
380000
-
-
Rattus norvegicus
500000
-
erythrocyte, sucrose density gradient centrifugation
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + D-fructose 6-phosphate
Gallus gallus
-
ADP + D-fructose 1,6-bisphosphate
-
Gallus gallus
?
ATP + D-fructose 6-phosphate
Lactobacillus plantarum
-
ADP + D-fructose 1,6-bisphosphate
-
Lactobacillus plantarum
?
ATP + D-fructose 6-phosphate
Mus musculus
-
ADP + D-fructose 1,6-bisphosphate
-
Mus musculus
?
ATP + D-fructose 6-phosphate
Thermus thermophilus
-
ADP + D-fructose 1,6-bisphosphate
-
Thermus thermophilus
?
ATP + D-fructose 6-phosphate
Escherichia coli
-
ADP + D-fructose 1,6-bisphosphate
-
Escherichia coli
?
ATP + D-fructose 6-phosphate
Homo sapiens
-
ADP + D-fructose 1,6-bisphosphate
-
Homo sapiens
?
ATP + D-fructose 6-phosphate
Rattus norvegicus
-
ADP + D-fructose 1,6-bisphosphate
-
Rattus norvegicus
?
ATP + D-fructose 6-phosphate
Saccharomyces cerevisiae
-
ADP + D-fructose 1,6-bisphosphate
-
Saccharomyces cerevisiae
?
ATP + D-fructose 6-phosphate
Bos taurus
-
ADP + D-fructose 1,6-bisphosphate
-
Bos taurus
?
ATP + D-fructose 6-phosphate
Oryctolagus cuniculus
-
ADP + D-fructose 1,6-bisphosphate
-
Oryctolagus cuniculus
?
ATP + D-fructose 6-phosphate
Neurospora crassa
-
ADP + D-fructose 1,6-bisphosphate
-
Neurospora crassa
?
ATP + D-fructose 6-phosphate
Ovis aries
-
ADP + D-fructose 1,6-bisphosphate
-
Ovis aries
?
ATP + D-fructose 6-phosphate
Pisum sativum
-
ADP + D-fructose 1,6-bisphosphate
-
Pisum sativum
?
ATP + D-fructose 6-phosphate
Zea mays
-
ADP + D-fructose 1,6-bisphosphate
-
Zea mays
?
ATP + D-fructose 6-phosphate
Klebsiella aerogenes
-
ADP + D-fructose 1,6-bisphosphate
-
Klebsiella aerogenes
?
ATP + D-fructose 6-phosphate
Dictyostelium discoideum
-
ADP + D-fructose 1,6-bisphosphate
-
Dictyostelium discoideum
?
ATP + D-fructose 6-phosphate
Lactobacillus casei
-
ADP + D-fructose 1,6-bisphosphate
-
Lactobacillus casei
?
ATP + D-fructose 6-phosphate
Clostridium pasteurianum
-
ADP + D-fructose 1,6-bisphosphate
-
Clostridium pasteurianum
?
ATP + D-fructose 6-phosphate
Daucus carota
-
ADP + D-fructose 1,6-bisphosphate
-
Daucus carota
?
ATP + D-fructose 6-phosphate
Glutamicibacter nicotianae
-
ADP + D-fructose 1,6-bisphosphate
-
Glutamicibacter nicotianae
?
ATP + D-fructose 6-phosphate
Fasciola hepatica
-
ADP + D-fructose 1,6-bisphosphate
-
Fasciola hepatica
?
ATP + D-fructose 6-phosphate
Arthrobacter crystallopoietes
-
ADP + D-fructose 1,6-bisphosphate
-
Arthrobacter crystallopoietes
?
ATP + D-fructose 6-phosphate
Brassica oleracea var. gemmifera
-
ADP + D-fructose 1,6-bisphosphate
-
Brassica oleracea var. gemmifera
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Clostridium pasteurianum
-
Homo sapiens
-
Mus musculus
-
Saccharomyces cerevisiae
-
Oryctolagus cuniculus
-
Bos taurus
-
Escherichia coli
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adipose tissue
-
Rattus norvegicus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Ovis aries
-
Ehrlich ascites carcinoma cell
-
Mus musculus
-
erythrocyte
-
Oryctolagus cuniculus
-
erythrocyte
-
Homo sapiens
-
heart
-
Bos taurus
-
heart
-
Oryctolagus cuniculus
-
heart
-
Ovis aries
-
kidney
cortex
Oryctolagus cuniculus
-
leaf
-
Brassica oleracea var. gemmifera
-
lens
calf
Bos taurus
-
leukocyte
-
Homo sapiens
-
liver
-
Gallus gallus
-
liver
-
Homo sapiens
-
liver
-
Oryctolagus cuniculus
-
muscle
-
Ovis aries
-
muscle
-
Rattus norvegicus
-
muscle
-
Bos taurus
-
muscle
-
Homo sapiens
-
muscle
-
Oryctolagus cuniculus
-
mycelium
-
Neurospora crassa
-
platelet
-
Homo sapiens
-
root
-
Daucus carota
-
seed
-
Daucus carota
-
seed
-
Pisum sativum
-
thyroid gland
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
93
-
heart muscle PFK
Bos taurus
99.5
-
human skeletal muscle
Homo sapiens
114
116
-
Gallus gallus
114
116
-
Saccharomyces cerevisiae
120
160
skeletal muscle PFK
Oryctolagus cuniculus
139
-
erythrocyte enzyme
Oryctolagus cuniculus
150
-
-
Mus musculus
160
-
-
Clostridium pasteurianum
160
-
-
Oryctolagus cuniculus
160
-
heart PFK
Ovis aries
189
215
-
Escherichia coli
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Gallus gallus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Mus musculus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Rattus norvegicus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
1,N6-etheno-ATP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
1,N6-etheno-ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Gallus gallus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Mus musculus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Rattus norvegicus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
2-amino-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
2-amino-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Gallus gallus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Mus musculus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Rattus norvegicus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
6-mercapto-9-beta-D-ribofuranosylpurine 5'-triphosphate + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
6-mercapto-9-beta-D-ribofuranosylpurine 5'-diphosphate + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
ATP + D-fructose 6-phosphate
-
640421
Gallus gallus
ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
ATP + D-fructose 6-phosphate
-
640421
Lactobacillus plantarum
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus plantarum
?
ATP + D-fructose 6-phosphate
-
640421
Mus musculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
ATP + D-fructose 6-phosphate
-
640421
Thermus thermophilus
ADP + D-fructose 1,6-bisphosphate
-
640421
Thermus thermophilus
?
ATP + D-fructose 6-phosphate
-
640421
Escherichia coli
ADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
ATP + D-fructose 6-phosphate
-
640421
Homo sapiens
ADP + D-fructose 1,6-bisphosphate
-
640421
Homo sapiens
?
ATP + D-fructose 6-phosphate
-
640421
Rattus norvegicus
ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
ATP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
ADP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
ATP + D-fructose 6-phosphate
-
640421
Bos taurus
ADP + D-fructose 1,6-bisphosphate
-
640421
Bos taurus
?
ATP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
ATP + D-fructose 6-phosphate
-
640421
Neurospora crassa
ADP + D-fructose 1,6-bisphosphate
-
640421
Neurospora crassa
?
ATP + D-fructose 6-phosphate
-
640421
Ovis aries
ADP + D-fructose 1,6-bisphosphate
-
640421
Ovis aries
?
ATP + D-fructose 6-phosphate
-
640421
Pisum sativum
ADP + D-fructose 1,6-bisphosphate
-
640421
Pisum sativum
?
ATP + D-fructose 6-phosphate
-
640421
Zea mays
ADP + D-fructose 1,6-bisphosphate
-
640421
Zea mays
?
ATP + D-fructose 6-phosphate
-
640421
Klebsiella aerogenes
ADP + D-fructose 1,6-bisphosphate
-
640421
Klebsiella aerogenes
?
ATP + D-fructose 6-phosphate
-
640421
Dictyostelium discoideum
ADP + D-fructose 1,6-bisphosphate
-
640421
Dictyostelium discoideum
?
ATP + D-fructose 6-phosphate
-
640421
Lactobacillus casei
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus casei
?
ATP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
ADP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
ATP + D-fructose 6-phosphate
-
640421
Daucus carota
ADP + D-fructose 1,6-bisphosphate
-
640421
Daucus carota
?
ATP + D-fructose 6-phosphate
-
640421
Glutamicibacter nicotianae
ADP + D-fructose 1,6-bisphosphate
-
640421
Glutamicibacter nicotianae
?
ATP + D-fructose 6-phosphate
-
640421
Fasciola hepatica
ADP + D-fructose 1,6-bisphosphate
-
640421
Fasciola hepatica
?
ATP + D-fructose 6-phosphate
-
640421
Arthrobacter crystallopoietes
ADP + D-fructose 1,6-bisphosphate
-
640421
Arthrobacter crystallopoietes
?
ATP + D-fructose 6-phosphate
-
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Gallus gallus
ADP + D-fructose 1,6-bisphosphate
-
640421
Gallus gallus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Lactobacillus plantarum
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus plantarum
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Mus musculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Mus musculus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Thermus thermophilus
ADP + D-fructose 1,6-bisphosphate
-
640421
Thermus thermophilus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Escherichia coli
ADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Homo sapiens
ADP + D-fructose 1,6-bisphosphate
-
640421
Homo sapiens
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Rattus norvegicus
ADP + D-fructose 1,6-bisphosphate
-
640421
Rattus norvegicus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Saccharomyces cerevisiae
ADP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Bos taurus
ADP + D-fructose 1,6-bisphosphate
-
640421
Bos taurus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Oryctolagus cuniculus
ADP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Neurospora crassa
ADP + D-fructose 1,6-bisphosphate
-
640421
Neurospora crassa
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Ovis aries
ADP + D-fructose 1,6-bisphosphate
-
640421
Ovis aries
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Pisum sativum
ADP + D-fructose 1,6-bisphosphate
-
640421
Pisum sativum
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Zea mays
ADP + D-fructose 1,6-bisphosphate
-
640421
Zea mays
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Klebsiella aerogenes
ADP + D-fructose 1,6-bisphosphate
-
640421
Klebsiella aerogenes
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Dictyostelium discoideum
ADP + D-fructose 1,6-bisphosphate
-
640421
Dictyostelium discoideum
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Lactobacillus casei
ADP + D-fructose 1,6-bisphosphate
-
640421
Lactobacillus casei
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Clostridium pasteurianum
ADP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Daucus carota
ADP + D-fructose 1,6-bisphosphate
-
640421
Daucus carota
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Glutamicibacter nicotianae
ADP + D-fructose 1,6-bisphosphate
-
640421
Glutamicibacter nicotianae
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Fasciola hepatica
ADP + D-fructose 1,6-bisphosphate
-
640421
Fasciola hepatica
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Arthrobacter crystallopoietes
ADP + D-fructose 1,6-bisphosphate
-
640421
Arthrobacter crystallopoietes
?
ATP + D-fructose 6-phosphate
poor substrates are fructose 1-phosphate, glucose 1-phosphate and sedoheptulose 7-phosphate
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
ATP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
ADP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
ATP + fructose 1-phosphate
-
640421
Escherichia coli
ADP + fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
ATP + fructose 1-phosphate
5% of activity with D-fructose 6-phosphate
640421
Oryctolagus cuniculus
ADP + fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
CTP + D-fructose 6-phosphate
-
640421
Escherichia coli
CDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
CTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
CDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
CTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
CDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
CTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
CDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
CTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
CDP + D-fructose 1,6-bisphosphate
-
-
-
-
dATP + D-fructose 6-phosphate
-
640421
Escherichia coli
dADP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
GTP + D-fructose 6-phosphate
-
640421
Escherichia coli
GDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
GTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
GDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
GTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
GDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
GTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
GDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
GTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
GDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
ITP + D-fructose 6-phosphate
-
640421
Escherichia coli
IDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
ITP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
IDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
ITP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
IDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
ITP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
IDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
ITP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
IDP + D-fructose 1,6-bisphosphate
-
-
-
-
TTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Escherichia coli
TDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
TTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
TDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
UTP + D-fructose 6-phosphate
-
640421
Escherichia coli
UDP + D-fructose 1,6-bisphosphate
-
640421
Escherichia coli
?
UTP + D-fructose 6-phosphate
-
640421
Saccharomyces cerevisiae
UDP + D-fructose 1,6-bisphosphate
-
640421
Saccharomyces cerevisiae
?
UTP + D-fructose 6-phosphate
-
640421
Oryctolagus cuniculus
UDP + D-fructose 1,6-bisphosphate
-
640421
Oryctolagus cuniculus
?
UTP + D-fructose 6-phosphate
-
640421
Clostridium pasteurianum
UDP + D-fructose 1,6-bisphosphate
-
640421
Clostridium pasteurianum
?
UTP + D-fructose 6-phosphate
purine NTPs preferred
640421
Brassica oleracea var. gemmifera
UDP + D-fructose 1,6-bisphosphate
-
640421
Brassica oleracea var. gemmifera
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 36500, sedimentation equilibrium centrifugation in 6 M guanidine
Escherichia coli
?
-
Homo sapiens
?
-
Mus musculus
hexamer
6 * 67000, muscle enzyme, sedimentation equilibrium ultracentrifugation or gel filtration in 6.5 M guanidine
Oryctolagus cuniculus
tetramer
-
Clostridium pasteurianum
tetramer
4 * 35000, isoenzyme PFK1, tetrahedral arranged subunits, SDS-PAGE
Escherichia coli
tetramer
-
Rattus norvegicus
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
-
-
liver enzyme, 2 h, 80% loss of activity by dissociation of enzyme
Gallus gallus
8
-
liver enzyme, 2 h, 60% loss of activity by dissociation of enzyme
Gallus gallus
40
60
30 min, stable
Gallus gallus
80
-
2 h
Thermus thermophilus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
additional information
-
-
Escherichia coli
additional information
-
pH-optimum depends on nucleoside triphosphate substrate
Saccharomyces cerevisiae
7.6
-
-
Fasciola hepatica
7.6
-
ITP, optima at pH 7.6 and pH 8.2
Saccharomyces cerevisiae
7.8
-
with ATP
Saccharomyces cerevisiae
8.2
-
ITP, optima at pH 7.6 and pH 8.2
Saccharomyces cerevisiae
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
additional information
-
heart enzyme, mild acidic conditions lead to reversible dissociation and decrease of activity, ATP or fructose 1,6-bisphosphate protects
Ovis aries
8
-
-
Oryctolagus cuniculus
8
-
relatively stable to inactivation by dilution, muscle enzyme
Ovis aries
Other publictions for EC 2.7.1.11
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737650
Kloos
Crystal structure of human pla ...
Homo sapiens
Biochem. J.
469
421-432
2015
1
-
-
1
1
-
1
4
-
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
1
1
-
-
1
2
4
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737846
Ramirez-Sarmiento
The folding unit of phosphofru ...
Escherichia coli
Biophys. J.
108
2350-2361
2015
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739167
Webb
Structures of human phosphofru ...
Homo sapiens
Nature
523
111-114
2015
-
1
-
1
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737382
Kloos
Crystallization and preliminar ...
Homo sapiens
Acta Crystallogr. Sect. F
70
578-582
2014
-
-
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Identification and characteriz ...
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Characterization of phosphofru ...
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van der Straat
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Overexpression of a modified 6 ...
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1
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1
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6
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2
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2
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1
1
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671923
Zancan
Clotrimazole inhibits and modu ...
Oryctolagus cuniculus
Biochem. Pharmacol.
73
1520-1527
2007
1
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1
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1
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672415
Mediavilla
Purification and kinetic prope ...
Sparus aurata
Biochim. Biophys. Acta
1770
706-715
2007
3
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4
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5
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4
4
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1
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3
1
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1
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1
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673599
Winkler
Purification, microsequencing ...
Spinacia oleracea
FEBS J.
274
429-438
2007
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1
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1
2
1
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2
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5
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1
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3
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6
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1
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3
3
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673683
Mustroph
Characterisation of the ATP-de ...
Arabidopsis thaliana
FEBS Lett.
581
2401-2410
2007
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1
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2
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7
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11
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1
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7
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675695
Barcena
The structure of the ATP-bound ...
Saccharomyces cerevisiae
J. Struct. Biol.
159
135-143
2007
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1
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677082
Kamp
Regulatory properties of 6-pho ...
Sus scrofa
Reproduction
133
29-40
2007
3
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1
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1
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1
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684338
Richard
Tissue-dependent loss of phosp ...
Mus musculus
Am. J. Physiol. Endocrinol. Metab.
293
E794-E801
2007
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2
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688695
Benjamin
Structures of S. pombe phospho ...
Schizosaccharomyces pombe
J. Struct. Biol.
159
498-506
2007
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1
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671462
Mlakar
citrate inhibition-resistant f ...
Aspergillus niger
Appl. Environ. Microbiol.
72
4515-4521
2006
2
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1
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2
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1
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-
-
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-
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673157
Seki
-
Two types of phosphofructokina ...
Gallus gallus
Comp. Biochem. Physiol. B
143B
344-350
2006
-
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1
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1
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3
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1
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-
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-
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-
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-
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673170
Simpfendoerfer
-
Phosphofructokinase from muscl ...
Austromegabalanus psittacus
Comp. Biochem. Physiol. C
142C
382-389
2006
4
-
-
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-
1
1
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-
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-
1
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1
1
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1
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1
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4
-
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1
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1
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1
1
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1
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1
-
-
-
-
-
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-
-
-
-
-
-
-
-
676022
Marinho-Carvalho
Modulation of 6-phosphofructo- ...
Oryctolagus cuniculus
Mol. Genet. Metab.
87
253-261
2006
-
-
-
-
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1
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1
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1
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1
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-
1
-
-
-
-
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-
-
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-
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671410
Mesojednik
Posttranslational modification ...
Aspergillus niger
Appl. Environ. Microbiol.
71
1425-1432
2005
-
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-
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2
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1
1
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2
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1
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2
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-
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-
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-
-
-
-
-
-
-
-
-
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675940
Faber-Barata
Opposing effects of two osmoly ...
Oryctolagus cuniculus
Mol. Cell. Biochem.
269
203-207
2005
1
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3
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1
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1
-
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-
-
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-
-
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676016
Zancan
Calcium influx: a possible rol ...
Homo sapiens
Mol. Genet. Metab.
86
392-400
2005
-
-
-
-
-
-
-
-
1
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1
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2
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2
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1
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1
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1
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2
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1
-
-
-
-
-
-
-
-
-
-
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-
-
-
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676017
Zancan
Regulation of human erythrocyt ...
Homo sapiens
Mol. Genet. Metab.
86
401-411
2005
-
-
-
-
-
-
-
-
-
-
-
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2
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1
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2
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1
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2
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640516
Keillor
Expression, purification, crys ...
Trypanosoma brucei
Acta Crystallogr. Sect. D
59
532-534
2003
-
-
-
1
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-
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1
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3
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1
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1
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1
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1
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1
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1
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-
-
-
-
-
-
-
-
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-
-
-
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640517
Fenton
Identification of Substrate Co ...
Escherichia coli
Biochemistry
42
6453-6459
2003
-
-
-
-
9
-
-
-
-
-
-
-
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2
-
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1
-
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-
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4
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9
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1
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-
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-
-
-
-
-
-
4
-
-
-
-
-
-
-
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-
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640518
Turner
Purification and characterizat ...
Musa acuminata
Planta
217
113-121
2003
-
-
-
-
-
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5
10
-
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2
-
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2
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1
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1
2
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5
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
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5
-
10
-
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2
-
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1
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1
2
-
5
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
661508
Xie
Oestrogen improves glucose met ...
Homo sapiens
Clin. Exp. Pharmacol. Physiol.
30
643-648
2003
1
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-
-
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1
-
-
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1
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1
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1
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2
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1
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1
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1
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1
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640514
Kirchberger
6-phosphofructokinase from Pic ...
Komagataella pastoris
Yeast
19
933-947
2002
2
-
-
-
-
-
1
-
-
-
4
1
-
4
-
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1
-
-
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1
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2
1
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2
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1
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4
1
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1
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1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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640515
Hansen
ATP-dependent 6-phosphofructok ...
Thermotoga maritima
Arch. Microbiol.
177
401-409
2002
1
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1
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1
3
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1
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7
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1
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1
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5
1
1
1
4
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1
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-
-
-
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1
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1
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-
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1
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3
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4
2
1
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1
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1
-
5
1
1
1
4
-
1
-
-
-
-
-
-
-
-
-
640527
Kemp
Evolution of the allosteric li ...
Mus musculus
Biochemistry
41
9426-9430
2002
-
-
-
-
2
-
-
-
-
-
-
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2
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-
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2
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-
-
-
-
-
-
-
-
-
-
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-
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-
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640510
Kimmel
Isolation of an individual all ...
Geobacillus stearothermophilus
Biochemistry
40
11623-11629
2001
-
-
-
-
3
-
-
-
-
-
-
-
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2
-
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-
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3
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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640511
Ding
Thermotoga maritima phosphofru ...
Thermotoga maritima
J. Bacteriol.
183
791-794
2001
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1
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-
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3
3
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4
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2
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1
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-
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5
1
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1
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1
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-
-
-
-
-
-
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1
-
-
-
-
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3
-
3
-
4
2
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1
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-
-
-
5
1
-
-
1
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1
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-
-
-
-
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640512
Alves
Different physiological roles ...
Amycolatopsis methanolica
J. Bacteriol.
183
7231-7240
2001
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1
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2
2
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9
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1
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1
1
4
2
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-
-
-
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-
-
-
-
-
-
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1
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-
-
-
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2
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2
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1
3
1
-
-
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1
-
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1
1
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640513
Hansen
Sequence, expression, and char ...
Aeropyrum pernix
Arch. Microbiol.
177
62-69
2001
-
-
-
-
-
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3
7
-
5
2
1
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6
-
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1
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-
-
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9
1
1
1
3
-
1
1
-
-
3
-
-
-
-
-
-
-
-
-
-
3
3
7
-
5
2
1
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-
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1
-
-
-
-
9
1
1
1
3
-
1
1
-
-
-
-
-
-
-
-
640525
Andersen
Twofold reduction of phosphofr ...
Lactococcus lactis
J. Bacteriol.
183
3458-3467
2001
-
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-
-
-
-
-
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1
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2
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-
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2
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1
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640526
Wang
Reaction path of phosphofructo ...
Escherichia coli
Biochemistry
40
3938-3942
2001
-
-
-
-
3
-
2
3
-
-
-
-
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2
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-
-
-
-
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3
-
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-
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3
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-
-
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-
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-
-
-
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3
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2
-
3
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-
-
-
-
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3
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
727544
Ronimus
Cloning, expression and charac ...
Aeropyrum pernix, Aeropyrum pernix DSM 11879
FEMS Microbiol. Lett.
202
85-90
2001
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1
-
-
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4
2
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2
1
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4
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-
-
-
-
-
-
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6
1
1
1
1
-
1
1
-
-
-
-
-
-
-
1
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4
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6
1
1
1
1
-
1
1
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-
640509
Hansen
Purification and properties of ...
Desulfurococcus amylolyticus
Arch. Microbiol.
173
103-109
2000
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6
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4
2
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6
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6
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1
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5
1
1
1
2
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1
1
-
1
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-
640523
Reuter
Purification, molecular and ki ...
Schizosaccharomyces pombe, Schizosaccharomyces pombe CBS1057
Yeast
16
1273-1285
2000
2
-
-
-
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2
1
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2
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4
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1
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1
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1
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1
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640524
Nicolau
Regulation of phosphofructokin ...
Rattus norvegicus
Arch. Physiol. Biochem.
108
437-443
2000
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4
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640505
Jagannatha Rao
Kinetic characterization of a ...
Dictyostelium discoideum
Arch. Biochem. Biophys.
365
335-343
1999
-
-
1
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1
1
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640507
Van Praag
Kinetic properties of ATP-depe ...
Citrus x paradisi
Biochem. Mol. Biol. Int.
47
749-756
1999
-
-
-
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6
1
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1
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6
5
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1
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2
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640508
Gunasekera
Cloning, sequencing, expressio ...
Mus musculus
Protein Expr. Purif.
16
448-453
1999
1
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1
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2
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1
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640521
Li
Identification of allosteric s ...
Oryctolagus cuniculus
Biochemistry
38
16407-16412
1999
2
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3
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3
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3
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640522
Wang
Identification of residues of ...
Escherichia coli
Biochemistry
38
4313-4318
1999
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15
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5
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2
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15
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640503
Bar
Purification and characterizat ...
Kluyveromyces lactis
Yeast
13
1309-1317
1997
2
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1
3
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1
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2
1
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640504
Sanchez-Martinez
Analysis of phosphofructokinas ...
Mus musculus, Rattus norvegicus
FEBS Lett.
409
86-90
1997
3
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2
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1
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640506
Estevez
Cloning, sequencing and develo ...
Ascaris suum
Eur. J. Biochem.
243
442-451
1997
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2
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1
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640520
Hagopian
The role of pyruvate dehydroge ...
Rattus norvegicus
Biochim. Biophys. Acta
1336
474-484
1997
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1
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640501
Ma
Characterization of expression ...
Rattus norvegicus
Biochim. Biophys. Acta
1308
151-163
1996
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1
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3
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3
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-
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640502
Zhao
Rabbit liver phosphofructokina ...
Oryctolagus cuniculus
Biochem. Biophys. Res. Commun.
222
410-415
1996
-
-
-
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2
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1
1
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2
1
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1
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640496
Yaney
Phosphofructokinase isozymes i ...
Rattus norvegicus
Diabetes
44
1285-1289
1995
2
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1
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4
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4
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-
-
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-
-
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640497
Su
Phosphofructokinase binding to ...
Oncorhynchus mykiss
Biochem. Mol. Biol. Int.
35
781-791
1995
-
-
-
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2
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2
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640498
Zhu
Role of glycine 212 in the all ...
Geobacillus stearothermophilus
Biochemistry
34
2560-2565
1995
1
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1
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1
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4
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2
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1
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2
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640499
Su
-
Fish muscle phosphofructokinas ...
Oncorhynchus mykiss
Int. J. Biochem. Cell Biol.
27
1277-1283
1995
3
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1
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1
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1
1
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1
1
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640500
Durante
Isozyme analysis of human norm ...
Homo sapiens
Biochem. Biophys. Res. Commun.
216
898-905
1995
1
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1
1
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2
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2
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1
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3
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1
1
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1
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1
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1
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2
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1
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3
-
-
1
1
-
-
-
-
-
-
-
-
-
-
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-
-
-
640519
Zheng
Phosphofructo-1-kinase: role o ...
Escherichia coli
Biochem. Biophys. Res. Commun.
214
765-770
1995
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3
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5
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2
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2
2
1
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3
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5
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-
-
-
-
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2
2
1
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-
-
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640484
Byrnes
Kinetic characteristics of pho ...
Geobacillus stearothermophilus
Biochemistry
33
3424-3431
1994
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1
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1
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2
9
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1
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-
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3
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1
1
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1
1
4
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1
-
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2
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-
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-
-
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1
-
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1
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2
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9
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1
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1
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1
1
4
-
1
-
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2
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727725
Yu
Pathway of glycogen metabolism ...
Methanococcus maripaludis
J. Bacteriol.
176
325-332
1994
5
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4
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5
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1
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1
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1
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1
1
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5
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4
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1
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1
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1
-
-
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1
1
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1
1
1
1
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-
640422
Mahajan
-
Properties of ATP-dependent ph ...
Triticum aestivum
J. Plant Biochem. Biotechnol.
1
45-48
1992
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5
2
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1
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1
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1
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1
1
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1
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4
-
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5
4
2
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1
1
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1
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1
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-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
640423
Valaitis
-
Molecular characterization of ...
Lymantria dispar
Insect Biochem. Mol. Biol.
22
481-489
1992
3
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1
2
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1
2
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1
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1
1
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1
1
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3
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1
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2
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1
2
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1
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1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640424
El Hachimi
Comparison of muscle phosphofr ...
Jaculus orientalis
Comp. Biochem. Physiol. B
102
507-513
1992
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-
-
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1
2
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1
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2
2
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1
1
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1
2
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1
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2
2
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1
1
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640425
Fukushima
Purification and characterizat ...
Bos taurus
Int. J. Biochem.
24
1307-1314
1992
2
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2
1
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1
1
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2
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1
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1
4
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1
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2
1
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1
1
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-
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-
-
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-
640475
Su
Phosphofructokinase from white ...
Oncorhynchus mykiss
Biochim. Biophys. Acta
1160
301-308
1992
2
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3
1
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4
1
1
1
1
1
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1
1
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1
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2
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1
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3
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1
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2
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1
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4
1
1
1
1
1
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1
1
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1
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640490
Zheng
The mechanism of ATP inhibitio ...
Escherichia coli, Escherichia coli DF1020
J. Biol. Chem.
267
23640-23645
1992
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1
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2
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1
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640440
Knowles
Characterization of ATP-depend ...
Ricinus communis
Plant Physiol.
92
155-159
1990
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4
5
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1
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1
1
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3
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2
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2
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1
2
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1
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640442
Surendranathan
-
Characterization of a monomeri ...
Musa acuminata
Plant Sci.
72
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1990
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4
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1
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1
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1
1
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5
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1
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640448
Botha
Molecular, kinetic, and immuno ...
Monoraphidium minutum
Plant Physiol.
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1990
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7
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1
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1
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1
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7
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1
1
3
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1
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1
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1
1
-
-
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-
1
1
-
-
-
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-
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-
640476
Krause
6-Phosphofructokinase from fro ...
Rana temporaria
Biochem. Soc. Trans.
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1990
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3
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3
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1
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1
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1
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1
-
1
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-
-
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-
-
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640477
Brooks
Phosphofructokinase from a ver ...
Trachemys scripta
Biochim. Biophys. Acta
1037
161-164
1990
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3
8
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1
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8
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1
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4
1
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1
-
2
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-
-
-
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-
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640489
Deville-Bonne
pH Dependence of the kinetic p ...
Escherichia coli
Biochemistry
30
5750-5754
1990
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1
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640426
Nagashima
-
Properties of phosphofructokin ...
Anguilla anguilla, Cyprinus carpio, Oncorhynchus mykiss
Nippon Suisan Gakkaishi
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1989
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2
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12
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-
-
-
-
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640445
Hausler
Cytosolic phosphofructokinase ...
Spinacia oleracea
Plant Physiol.
90
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1989
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2
5
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1
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1
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1
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640446
Hausler
Cytosolic phosphofructokinase ...
Spinacia oleracea
Plant Physiol.
90
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1989
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5
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1
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5
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1
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640471
McCune
Aurintricarboxylic acid is a p ...
Oryctolagus cuniculus
Biochem. J.
259
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1989
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1
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640491
Kruger
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Effects of temperature on the ...
Escherichia coli, Escherichia coli DF1020
Biochem. Soc. Trans.
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1989
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2
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1
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640493
Rypniewski
Crystal structure of unligande ...
Escherichia coli
J. Mol. Biol.
207
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1989
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1
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640427
Botha
-
Kinetic properties of the ATP- ...
Cucumis sativus
Plant Cell Physiol.
29
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1988
1
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1
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2
1
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1
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1
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1
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-
-
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640428
Cawood
-
Molecular properties of the AT ...
Cucumis sativus
Plant Cell Physiol.
29
195-199
1988
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7
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1
1
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1
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7
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1
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1
1
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-
-
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640439
Kruger
Molecular characterization of ...
Escherichia coli, Escherichia coli DF1020, Solanum acaule, Solanum commersonii, Solanum megistacrolobum, Solanum tuberosum
Arch. Biochem. Biophys.
267
690-700
1988
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8
2
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5
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8
6
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2
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8
2
5
12
5
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640443
Cawood
-
Properties of the phosphofruct ...
Cucumis sativus
J. Plant Physiol.
132
204-209
1988
1
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9
20
2
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1
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1
2
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5
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1
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-
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1
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9
-
20
2
1
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1
2
-
5
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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640457
Leite
Phosphofructokinase from bumbl ...
Bombus atratus
J. Biol. Chem.
263
17527-17533
1988
2
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-
-
-
-
2
3
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1
1
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-
2
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-
1
1
-
1
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
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2
-
3
-
1
1
-
-
-
-
1
-
1
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640478
Brooks
Purification of phosphofructok ...
Trachemys scripta
J. Chromatogr.
455
291-296
1988
-
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-
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1
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1
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1
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1
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1
3
1
1
-
1
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
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1
-
-
-
-
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1
-
1
3
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640492
Shirakihara
Crystal structure of the compl ...
Escherichia coli, Escherichia coli DF1020, Geobacillus stearothermophilus
J. Mol. Biol.
204
973-994
1988
-
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2
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2
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9
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1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
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2
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2
-
-
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1
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-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640429
Khoja
The purification, characteriza ...
Camelus dromedarius
Comp. Biochem. Physiol. B
87
335-340
1987
4
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-
-
-
-
2
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1
1
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-
3
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1
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-
3
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1
1
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-
-
-
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4
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-
-
-
-
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-
2
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1
1
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-
-
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1
-
3
-
-
1
1
-
-
-
-
-
-
-
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-
-
-
-
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640441
Wong
A novel type of phosphofructok ...
Daucus carota
J. Biol. Chem.
262
3185-3191
1987
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1
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4
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1
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1
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1
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1
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1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640456
Kamemoto
Phosphofructokinase from Fasci ...
Fasciola hepatica, Ovis aries
Arch. Biochem. Biophys.
258
101-111
1987
5
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8
2
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1
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2
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2
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2
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5
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8
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2
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3
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1
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2
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
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640470
Carpenter
Stabilization of phosphofructo ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
923
109-115
1987
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-
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2
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2
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2
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1
-
1
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-
-
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2
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-
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2
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1
-
1
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-
-
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640479
Beinhauer
-
...
Apis mellifera, Calliphoridae, Locusta migratoria
Biochem. Soc. Trans.
15
378-379
1987
8
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3
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8
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8
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2
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1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640430
Aguilar
The phosphofructokinase of Try ...
Trypanosoma cruzi
Mol. Biochem. Parasitol.
21
103-111
1986
-
-
-
-
-
-
1
1
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1
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1
1
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2
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1
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-
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-
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-
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1
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1
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1
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1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640436
Isaac
-
Phosphofructokinase from Lycop ...
Solanum lycopersicum
Phytochemistry
25
339-343
1986
-
-
-
-
-
-
5
1
-
1
-
1
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1
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1
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5
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1
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-
-
-
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-
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5
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1
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1
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1
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1
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5
-
1
-
-
-
-
-
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640455
Kamemoto
Phosphofructokinase in the liv ...
Fasciola hepatica, Ovis aries
J. Biol. Chem.
261
4346-4351
1986
4
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4
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1
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2
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1
2
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2
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4
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-
-
-
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2
2
4
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2
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1
1
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2
-
1
2
-
-
-
-
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640458
Wegener
Antagonistic effects of hexose ...
Apis mellifera
Biochem. J.
236
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1986
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1
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1
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4
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2
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1
1
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1
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1
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Brand
Zn2+-dependent reversible inac ...
Rattus norvegicus
J. Biol. Chem.
261
5892-5900
1986
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1
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660825
Banerjee
Accumulation of fructose 1,6-b ...
Pseudomonas aeruginosa
Arch. Microbiol.
144
405-407
1986
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1
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640431
Ozawa
Purification and kinetic prope ...
Rattus norvegicus
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30
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1985
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1
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640432
Kelly
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Purification, kinetics and reg ...
Auxenochlorella pyrenoidosa
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26
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1
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1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
640451
Nwagwu
-
Phosphofructokinase of Trypano ...
Trypanosoma brucei
Biochem. Soc. Trans.
13
890-891
1985
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
-
2
-
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1
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-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640452
Cronin
Purification and regulatory pr ...
Trypanosoma brucei
Biochem. J.
227
113-124
1985
3
-
-
-
-
3
5
5
1
-
2
-
-
2
-
-
1
-
-
-
1
1
1
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
5
-
5
1
-
2
-
-
-
-
1
-
-
1
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640438
Ashihara
Comparison of activities and p ...
Vigna mungo
J. Plant Physiol.
116
241-252
1984
1
-
-
-
-
-
3
4
-
1
-
-
-
3
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
4
-
1
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640472
Kasten
Purification of homogeneous ra ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
111
462-469
1983
-
-
-
-
-
-
-
-
-
-
-
-
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3
-
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1
-
-
4
2
-
1
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-
-
-
-
-
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-
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-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
1
-
4
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640473
Khoja
The isolation and characteriza ...
Rattus norvegicus
Biochem. J.
211
373-379
1983
-
-
-
-
-
-
1
-
-
-
3
-
-
2
-
-
1
-
-
4
1
-
1
1
1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
1
-
4
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640480
Habison
Partial purification and regul ...
Aspergillus niger, Aspergillus niger B60
Biochem. J.
209
669-676
1983
5
-
-
-
-
2
6
2
-
-
-
-
-
5
-
-
1
-
-
1
1
-
4
-
1
-
-
-
1
-
-
-
3
-
-
5
-
-
-
-
-
2
-
6
3
2
-
-
-
-
-
-
-
1
-
1
1
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640437
Isaac
-
Purification and properties of ...
Solanum lycopersicum
Phytochemistry
21
1553-1556
1982
-
-
-
-
-
3
4
-
-
1
2
1
-
1
-
-
1
-
-
-
1
3
2
-
1
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
3
-
4
-
-
-
1
2
1
-
-
-
1
-
-
1
3
2
-
1
-
2
-
1
1
-
-
-
-
-
-
-
-
640447
Kombrink
Chloroplast phosphofructokinas ...
Dunaliella marina
Arch. Biochem. Biophys.
213
602-619
1982
1
-
-
-
-
1
10
2
4
1
3
-
-
3
-
-
1
-
-
-
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
1
-
10
-
2
4
1
3
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
640453
Starling
Phosphofructokinase from Ascar ...
Ascaris suum, Oryctolagus cuniculus
J. Biol. Chem.
257
3795-3800
1982
-
-
-
-
-
-
-
-
-
-
4
-
-
4
-
-
1
-
-
4
-
1
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
1
-
4
-
1
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640454
Hofer
Phosphofructokinase from Ascar ...
Ascaris suum
J. Biol. Chem.
257
3801-3806
1982
6
-
-
-
-
1
2
1
-
2
-
-
-
2
-
-
-
-
-
1
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
6
-
-
-
-
-
1
-
2
-
1
-
2
-
-
-
-
-
-
-
1
1
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
640459
Ui
Phosphofructokinase from Ehrli ...
Mus musculus
Methods Enzymol.
90
35-38
1982
1
-
-
-
-
-
2
-
-
2
1
-
-
1
-
-
1
1
-
1
1
1
1
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
2
1
-
-
-
-
1
-
1
1
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640460
Storey
Phosphofructokinase from oyste ...
Crassostrea virginica
Methods Enzymol.
90
39-44
1982
1
-
-
-
-
1
3
3
-
1
1
-
-
1
-
-
1
-
-
-
1
1
1
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
3
-
3
-
1
1
-
-
-
-
1
-
-
1
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640461
Harris
Phosphofructokinase from Ascar ...
Ascaris suum
Methods Enzymol.
90
44-49
1982
3
-
-
-
-
-
2
-
-
2
1
-
-
2
-
1
1
-
-
2
-
2
1
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
2
-
-
-
2
1
-
-
-
1
1
-
2
-
2
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640462
Hofmann
Phosphofructokinase from yeast ...
Saccharomyces cerevisiae
Methods Enzymol.
90
49-60
1982
4
-
-
-
-
3
3
1
-
2
3
1
-
2
-
-
1
1
-
-
1
3
2
1
1
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
3
-
3
-
1
-
2
3
1
-
-
-
1
-
-
1
3
2
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
640463
Kotlarz
Phosphofructokinases from Esch ...
Escherichia coli
Methods Enzymol.
90
60-70
1982
-
-
-
-
-
-
2
2
-
2
2
-
-
1
-
-
1
-
-
-
2
1
10
3
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
2
2
-
-
-
-
1
-
-
2
1
10
3
1
-
-
-
2
-
-
-
-
-
-
-
-
-
640464
Marschke
Phosphofructokinase from Bacil ...
Bacillus licheniformis, Bacillus sp. (in: Bacteria)
Methods Enzymol.
90
70-77
1982
1
-
-
-
-
4
5
3
2
6
2
-
-
3
-
-
2
-
-
-
1
1
2
-
2
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
4
-
5
1
3
2
6
2
-
-
-
-
2
-
-
1
1
2
-
2
-
2
-
1
-
-
-
-
-
-
-
-
-
640465
Fordyce
Phosphofructokinase from Strep ...
Lactococcus lactis, Lactococcus lactis C10
Methods Enzymol.
90
77-82
1982
2
-
-
1
-
4
6
2
-
6
1
-
-
5
-
-
1
-
-
-
1
2
2
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
1
-
4
-
6
-
2
-
6
1
-
-
-
-
1
-
-
1
2
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
640466
Gottschalk
Phosphofructokinase from Clost ...
Clostridium pasteurianum
Methods Enzymol.
90
82-87
1982
-
-
-
-
-
-
7
2
-
5
1
-
-
2
-
-
1
-
-
-
1
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
2
-
5
1
-
-
-
-
1
-
-
1
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
640433
Sand
-
Kinetic properties of phosphof ...
Platichthys flesus
Comp. Biochem. Physiol. B
69
435-443
1981
-
-
-
-
-
-
3
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640434
Tellam
-
The purification and propertie ...
Xenopus laevis
Comp. Biochem. Physiol. B
69
517-522
1981
-
-
-
-
-
1
-
1
-
1
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
640435
Leaver
-
Purification and properties of ...
Gadus morhua
Comp. Biochem. Physiol. B
69
127-132
1981
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640450
Royt
Partial characterization and i ...
Tetrahymena pyriformis
Biochim. Biophys. Acta
657
138-152
1981
-
-
-
-
-
-
4
-
2
-
1
-
-
3
-
-
1
-
-
-
-
-
1
-
-
-
1
-
2
1
2
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
2
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
2
1
2
-
-
-
-
-
-
-
640481
Welch
Rapid purification and crystal ...
Saccharomyces cerevisiae
Anal. Biochem.
112
154-157
1981
-
-
-
1
-
-
-
-
-
-
2
-
-
2
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640482
Zeidan
Purification and characterizat ...
Rhodotorula glutinis
Biochem. Biophys. Res. Commun.
100
681-687
1981
-
-
-
-
-
1
3
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640494
Simon
Phosphofructokinases from Lact ...
Lactobacillus acidophilus, Lactobacillus plantarum, Streptococcus thermophilus
Biochim. Biophys. Acta
661
158-163
1981
-
-
-
-
-
-
3
5
-
3
-
-
-
7
-
-
1
-
-
-
1
-
3
-
3
-
8
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
5
-
3
-
-
-
-
-
1
-
-
1
-
3
-
3
-
8
-
1
1
-
-
-
-
-
-
-
-
640444
Garland
Plastid and cytosolic phosphof ...
Ricinus communis
Arch. Biochem. Biophys.
204
302-309
1980
1
-
-
-
-
1
3
-
4
1
1
-
-
2
-
-
1
-
-
2
1
1
1
-
1
-
-
-
2
1
-
-
-
-
-
1
-
-
-
-
-
1
-
3
-
-
4
1
1
-
-
-
-
1
-
2
1
1
1
-
1
-
-
-
2
1
-
-
-
-
-
-
-
-
640467
Kemp
Phosphofructokinase from rabbi ...
Oryctolagus cuniculus
Methods Enzymol.
42C
67-71
1975
1
-
-
-
-
1
1
-
-
-
-
-
-
2
-
-
1
-
-
2
1
1
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
1
-
2
1
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640468
Kemp
-
Phosphofructokinase from yeast ...
Oryctolagus cuniculus
Methods Enzymol.
42C
71-77
1975
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
1
-
-
1
1
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
640469
Stellwagen
Phosphofructokinase from rabbi ...
Saccharomyces cerevisiae
Methods Enzymol.
42C
78-85
1975
3
-
-
-
-
1
2
-
-
3
-
-
-
2
-
-
1
1
-
-
1
2
1
-
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
1
-
2
-
-
-
3
-
-
-
-
-
1
-
-
1
2
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
640485
Uyeda
-
Phosphofructokinase from Clost ...
Clostridium pasteurianum
Methods Enzymol.
42C
86-91
1975
2
-
-
1
-
-
1
3
-
2
2
-
-
1
-
-
1
-
-
-
1
1
5
1
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
1
-
-
-
1
-
3
-
2
2
-
-
-
-
1
-
-
1
1
5
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
640486
Kemerer
-
Phosphofructokinase from Esche ...
Escherichia coli
Methods Enzymol.
42C
91-98
1975
2
-
-
-
-
-
3
1
-
2
1
-
-
1
-
-
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
3
-
1
-
2
1
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640487
Massey
Phosphofructokinase from porci ...
Bos taurus, Capra hircus, Gallus gallus, Homo sapiens, Oryctolagus cuniculus, Ovis aries, Sus scrofa
Methods Enzymol.
42C
99-110
1975
-
-
-
4
-
-
5
3
-
-
1
-
-
7
-
-
1
-
-
9
2
1
7
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
4
-
-
-
5
1
3
-
-
1
-
-
-
-
1
-
9
2
1
7
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
640488
Layzer
-
Phosphofructokinase from human ...
Homo sapiens
Methods Enzymol.
42C
110-115
1975
-
-
-
-
-
-
2
3
-
-
1
-
-
1
-
-
1
-
-
1
1
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
3
-
-
1
-
-
-
-
1
-
1
1
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640495
Baumann
Catabolism of D-fructose and D ...
Oceanimonas doudoroffii, Oceanimonas doudoroffii M1
Arch. Microbiol.
105
241-248
1975
2
-
-
-
-
-
4
2
-
3
-
-
-
3
-
-
1
-
-
-
1
2
10
-
-
-
-
-
1
1
-
-
-
-
-
2
-
-
-
-
-
-
-
4
-
2
-
3
-
-
-
-
-
1
-
-
1
2
10
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
640449
Reeves
Pyrophosphate:D-fructose 6-pho ...
Entamoeba histolytica, Entamoeba histolytica H200
J. Biol. Chem.
249
7737-7741
1974
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640421
Bloxham
-
Phosphofructokinase ...
Arthrobacter crystallopoietes, Bos taurus, Brassica oleracea var. gemmifera, Clostridium pasteurianum, Daucus carota, Dictyostelium discoideum, Escherichia coli, Fasciola hepatica, Gallus gallus, Glutamicibacter nicotianae, Homo sapiens, Klebsiella aerogenes, Lactobacillus casei, Lactobacillus plantarum, Mus musculus, Neurospora crassa, Oryctolagus cuniculus, Ovis aries, Pisum sativum, Rattus norvegicus, Saccharomyces cerevisiae, Thermus thermophilus, Zea mays
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
8
239-278
1973
18
-
-
5
-
2
113
23
23
87
9
23
-
23
-
-
7
-
-
28
11
-
84
7
-
-
4
-
6
-
3
-
7
-
-
18
-
-
-
5
-
2
-
113
7
23
23
87
9
23
-
-
-
7
-
28
11
-
84
7
-
-
4
-
6
-
3
-
-
-
-
-
-
-
640483
Sapico
D-fructose 1-phosphate kinase ...
Klebsiella aerogenes
J. Biol. Chem.
244
6280-6288
1969
-
-
-
-
-
-
7
3
-
-
1
-
-
1
-
-
1
-
-
-
1
-
1
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
3
-
-
1
-
-
-
-
1
-
-
1
-
1
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-