Literature summary for 2.7.1.107 extracted from

Poli, A.; Fiume, R.; Baldanzi, G.; Capello, D.; Ratti, S.; Gesi, M.; Manzoli, L.; Graziani, A.; Suh, P.G.; Cocco, L.; Follo, M.Y.
Nuclear localization of diacylglycerol kinase alpha in K562 cells is involved in cell cycle progression (2017), J. Cell. Physiol., 232, 2550-2557 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
R59022	-	Homo sapiens
R59949	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P23743	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythroleukemia cell	-	Homo sapiens	-
K-562 cell	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 80000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
DGKalpha	isoform	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	nuclear isoform DGKalpha modulates cell cycle progression, and its activity or expression can lead to changes in the phosphorylated status of the retinoblastoma protein, thus, impairing G1/S transition and, subsequently, inducing cell cycle arrest, which is often uncoupled with apoptosis or autophagy induction. Nuclear enzyme activity drives K-562 cells through the G1/S transition during cell cycle progression	Homo sapiens

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Release 2023.1 (January 2023)