Literature summary for 2.7.1.107 extracted from

Franks, C.E.; Campbell, S.T.; Purow, B.W.; Harris, T.E.; Hsu, K.L.
The ligand binding landscape of diacylglycerol kinases (2017), Cell Chem. Biol., 24, 870-880.e5 .

Search for more literature for 2.7.1.107

Inhibitors

Inhibitors	Comment	Organism	Structure
4-[bis(4-fluorophenyl)methylidene]piperidine	-	Homo sapiens
additional information	isoform DGKalpha is not inhibited by ketanserin	Homo sapiens
ritanserin	inhibitor of isoform DGKalpha	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	50 mM used in assay conditions	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P23743	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1,2-dioleoyl-sn-glycerol	-	Homo sapiens	ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 80000, isoform DGKalpha, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
DGKA	isoform	Homo sapiens
DGKalpha	isoform	Homo sapiens
diacylglycerol kinase alpha	isoform	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.025	-	isoform DGKalpha, pH and temperature not specified in the publication	Homo sapiens	ritanserin
0.223	-	isoform DGKalpha, pH and temperature not specified in the publication	Homo sapiens	4-[bis(4-fluorophenyl)methylidene]piperidine

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Release 2023.1 (January 2023)